Clinical significance of IgM and C3 glomerular deposition in primary focal segmental glomerulosclerosis

Clinical Journal of the American Society of Nephrology

Volumn 11, Issue 9, 2016, Pages 1582-1589

  Zhang, Yi Miao ^a,b,c,d   Gu, Qiu Hua ^a,b,c,d   Huang, Jing ^a,b,c,d   Qu, Zhen ^a,b,c,d   Wang, Xin ^a,b,c,d   Meng, Li Qiang ^a,b,c,d   Wang, Fang ^a,b,c,d   Liu, Gang ^a,b,c,d   Cui, Zhao ^a,b,c,d   Zhao, Ming Hui ^a,b,c,d,e  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

^c BEIJING HOSPITAL   (China)

^d BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^e Tsinghua University   (China)

Author keywords

Biopsy; Complement; Complement Activation; Creatinine; Disease Progression; Focal segmental glomerulosclerosis; Follow Up Studies; Humans; Immunoglobulin M; Outcomes; Prevalence; Risk factors

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; CORTICOSTEROID; CREATININE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMMUNOGLOBULIN M ANTIBODY; IMMUNOSUPPRESSIVE AGENT; PREDNISONE; TACROLIMUS; IMMUNOGLOBULIN M;

ADULT; AGE; ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; FOCAL GLOMERULOSCLEROSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN DEPOSITION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; MAJOR CLINICAL STUDY; MALE; PROTEINURIA; RETROSPECTIVE STUDY; TREATMENT OUTCOME; TREATMENT RESPONSE; ADOLESCENT; BIOPSY; BLOOD; GLOMERULUS; GLOMERULUS FILTRATION RATE; KIDNEY FAILURE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; RECURRENT DISEASE; REMISSION; RISK FACTOR; TREATMENT FAILURE; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; BIOPSY; COMPLEMENT C1Q; COMPLEMENT C3; FEMALE; GLOMERULAR FILTRATION RATE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENTS; KIDNEY GLOMERULUS; MALE; MIDDLE AGED; RECURRENCE; REMISSION INDUCTION; RENAL INSUFFICIENCY; RETROSPECTIVE STUDIES; RISK FACTORS; TREATMENT FAILURE; YOUNG ADULT;

EID: 85021137566     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.01190216     Document Type: Article

References (35)

1. D’Agati VD, Kaskel FJ, Falk RJ: Focal segmental glomerulosclerosis. N Engl J Med 365: 2398-2411, 2011
2. Gephardt GN, Tubbs RR, Popowniak KL, McMahon JT: Focal and segmental glomerulosclerosis. Immunohistologic study of 20 renal biopsy specimens. Arch Pathol Lab Med 110: 902-905, 1986
3. Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanović D, Holers VM, Thurman JM: IgMcontributes to glomerular injury in FSGS. J Am Soc Nephrol 24: 393-406, 2013
4. Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Huber KM, Zhong W, Pickering MC, Holers VM, Thurman JM: IgM exacerbates glomerular disease progression in complement-induced glomerulopathy. Kidney Int 88: 528-537, 2015
5. D’Agati VD, Fogo AB, Bruijn JA, Jennette JC: Pathologic classification of focal segmental glomerulosclerosis: A working proposal. Am J Kidney Dis 43: 368-382, 2004
6. Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, Li Y, Xu JS, Huang SM, Wang LN, Huang W, Wang M, Xu GB, Wang HY: Modified glomerular filtration rate estimating equation for Chinese patientswith chronic kidney disease. J Am Soc Nephrol 17: 2937-2944, 2006
7. Huang J, Liu G, Zhang YM, Cui Z, Wang F, Liu XJ, Chu R, Chen Y, Zhao MH: Plasma soluble urokinase receptor levels are increased but do not distinguish primary from secondary focal segmental glomerulosclerosis. Kidney Int 84: 366-372, 2013
8. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group: KDIGOclinical practice guideline for glomerulonephritis. Kidney Int Suppl 2: 139-274, 2012
9. Winn MP, Conlon PJ, Lynn KL, Howell DN, Gross DA, Rogala AR, Smith AH, Graham FL, Bembe M, Quarles LD, Pericak-Vance MA, Vance JM; International Collaborative Group for the Study of Familial Focal Segmental Glomerulosclerosis: Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. Kidney Int 55: 1241-1246, 1999
10. Caridi G, Bertelli R, Carrea A, Di Duca M, Catarsi P, Artero M, Carraro M, Zennaro C, Candiano G, Musante L, Seri M, Ginevri F, Perfumo F, Ghiggeri GM: Prevalence, genetics, and clinical features of patients carrying podocin mutations in steroidresistant nonfamilial focal segmental glomerulosclerosis. J Am Soc Nephrol 12: 2742-2746, 2001
11. Caridi G, Bertelli R, Scolari F, Sanna-Cherchi S, Di Duca M, Ghiggeri GM: Podocin mutations in sporadic focal-segmental glomerulosclerosis occurring in adulthood. Kidney Int 64: 365, 2003
12. Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB: A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308: 1801-1804, 2005
13. Wolf G, Stahl RA: CD2-associated protein and glomerular disease. Lancet 362: 1746-1748, 2003
14. Savin VJ, Sharma R, Sharma M, McCarthy ET, Swan SK, Ellis E, Lovell H, Warady B, Gunwar S, Chonko AM, Artero M, Vincenti F: Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med 334: 878-883, 1996
15. McCarthy ET, Sharma M, Savin VJ: Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 5: 2115-2121, 2010
16. Wei C, El Hindi S, Li J, Fornoni A, Goes N, Sageshima J, Maiguel D, Karumanchi SA, Yap HK, Saleem M, Zhang Q, Nikolic B, Chaudhuri A, Daftarian P, Salido E, Torres A, Salifu M, Sarwal MM, Schaefer F, Morath C, Schwenger V, Zeier M, Gupta V, Roth D, Rastaldi MP, Burke G, Ruiz P, Reiser J: Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med 17: 952-960, 2011
17. D’Agati VD: The spectrum of focal segmental glomerulosclerosis: New insights. Curr Opin Nephrol Hypertens 17: 271-281, 2008
18. Friedman EA, Tao TK: Disappearance of uremia due to heroinassociated nephropathy. Am J Kidney Dis 25: 689-693, 1995
19. Markowitz GS, Appel GB, Fine PL, Fenves AZ, Loon NR, Jagannath S, Kuhn JA, Dratch AD, D’Agati VD: Collapsing focal segmental glomerulosclerosis following treatment with highdose pamidronate. J Am Soc Nephrol 12: 1164-1172, 2001
20. Marras D, Bruggeman LA, Gao F, Tanji N, Mansukhani MM, Cara A, Ross MD, Gusella GL, Benson G, D’Agati VD, Hahn BH, Klotman ME, Klotman PE: Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med 8: 522-526, 2002
21. Moudgil A, Nast CC, Bagga A, Wei L, Nurmamet A, Cohen AH, Jordan SC, Toyoda M: Association of parvovirus B19 infection with idiopathic collapsing glomerulopathy. Kidney Int 59: 2126-2133, 2001
22. Nagata M, Kriz W: Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis. Kidney Int 42: 148-160, 1992
23. Hsu HC, Chen WY, Lin GJ, Chen L, Kao SL, Huang CC, Lin CY: Clinical and immunopathologic study of mesangial IgM nephropathy: Report of 41 cases. Histopathology 8: 435-446, 1984
24. Disciullo SO, Abuelo JG, Moalli K, Pezzullo JC: Circulating heavy IgM in IgM nephropathy. Clin Exp Immunol 73: 395-400, 1988
25. Hamaguchi Y, Uchida J, Cain DW, Venturi GM, Poe JC, Haas KM, Tedder TF: The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. J Immunol 174: 4389-4399, 2005
26. Baumgarth N: The double life of a B-1 cell: Self-reactivity selects for protective effector functions. Nat Rev Immunol 11: 34-46, 2011
27. Cohen AH, Border WA, Glassock RJ: Nehprotic syndrome with glomerular mesangial IgM deposits. Lab Invest 38: 610-619, 1978
28. Turnberg D, Lewis M, Moss J, Xu Y, Botto M, Cook HT: Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice. J Immunol 177: 4094-4102, 2006
29. Lenderink AM, Liegel K, Ljubanović D, Coleman KE, Gilkeson GS, Holers VM, Thurman JM: The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy. Am J Physiol Renal Physiol 293: F555-F564, 2007
30. Thurman JM, Wong M, Renner B, Frazer-Abel A, Giclas PC, Joy MS, Jalal D, Radeva MK, Gassman J, Gipson DS, Kaskel F, Friedman A, Trachtman H: Complement Activation in Patients with Focal Segmental Glomerulosclerosis. PLoS One 10: e0136558, 2015
31. Atkinson JP, Frank MM: Effect of cortisone therapy on serum complement components. J Immunol 111: 1061-1066, 1973
32. Lemercier C, Julen N, Coulpier M, Dauchel H, Ozanne D, Fontaine M, Ripoche J: Differential modulation by glucocorticoids of alternative complement protein secretion in cells of the monocyte/macrophage lineage. Eur J Immunol 22: 909-915, 1992
33. Martin F, Chan AC: B cell immunobiology in disease: Evolving concepts from the clinic. Annu Rev Immunol 24: 467-496, 2006
34. Fernandez-Fresnedo G, Segarra A, González E, Alexandru S, Delgado R, Ramos N, Egido J, Praga M; Trabajo de Enfermedades Glomerulares de la Sociedad Espa~nola de Nefrología (GLOSEN): Rituximab treatment of adult patients with steroid-resistant focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 4: 1317-1323, 2009
35. Ruggenenti P, Ruggiero B, Cravedi P, Vivarelli M, Massella L, Marasà M, Chianca A, Rubis N, Ene-Iordache B, Rudnicki M, Pollastro RM, Capasso G, Pisani A, Pennesi M, Emma F, Remuzzi G; Rituximab in Nephrotic Syndrome of Steroid-Dependent or Frequently Relapsing Minimal Change Disease Or Focal Segmental Glomerulosclerosis (NEMO) Study Group: Rituximab in steroid-dependent or frequently relapsing idiopathic nephrotic syndrome. J Am Soc Nephrol 25: 850-863, 2014