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Volumn 58, Issue 6, 2017, Pages 1221-1229

TM6SF2 rs58542926 variant affects postprandial lipoprotein metabolism and glucose homeostasis in NAFLD

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; CHOLESTEROL; GASTRIC INHIBITORY POLYPEPTIDE; GLUCOSE; INCRETIN; INSULIN; LIPOPROTEIN; MEMBRANE PROTEIN; TRANSMEMBRANE 6 SUPERFAMILY MEMBER 2; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; TM6SF2 PROTEIN, HUMAN;

EID: 85021110907     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M075028     Document Type: Article
Times cited : (45)

References (43)
  • 1
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of NAFLD: Practice guidelines by the AASLD, ACG and the AGA
    • Chalasani, N., Z. Younossi, and J. E. Lavine. 2012. The diagnosis and management of NAFLD: practice guidelines by the AASLD, ACG and the AGA. Hepatology. 55: 2005-2023.
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 2
    • 80555136061 scopus 로고    scopus 로고
    • Metaanalysis: Natural history of NAFLD and diagnostic accuracy of noninvasive tests for liver disease severity
    • Musso, G., M. Cassader, R. Gambino, and G. F. Pagano. 2011. Metaanalysis: natural history of NAFLD and diagnostic accuracy of noninvasive tests for liver disease severity. Ann. Med. 43: 617-649.
    • (2011) Ann. Med. , vol.43 , pp. 617-649
    • Musso, G.1    Cassader, M.2    Gambino, R.3    Pagano, G.F.4
  • 3
    • 84904539724 scopus 로고    scopus 로고
    • Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: A systematic review
    • Schwab, U., L. Lauritzen, and T. Tholstrup. 2014. Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review. Food Nutr. Res. 58: 25145.
    • (2014) Food Nutr. Res. , vol.58 , pp. 25145
    • Schwab, U.1    Lauritzen, L.2    Tholstrup, T.3
  • 4
    • 33644897826 scopus 로고    scopus 로고
    • Adaptive failure to high-fat diet characterizes steatohepatitis in alms1 mutant mice
    • Arsov, T., C. Z. Carter, and C.J. Nolan. 2006. Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem. Biophys. Res. Commun. 342: 1152-1159.
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 1152-1159
    • Arsov, T.1    Carter, C.Z.2    Nolan, C.J.3
  • 5
    • 18844458833 scopus 로고    scopus 로고
    • Dietary fat content modifies liver fat in overweight nondiabetic subjects
    • Westerbacka, J., K. Lammi, and A. M. Hakkinen. 2005. Dietary fat content modifies liver fat in overweight nondiabetic subjects. J. Clin. Endocrinol. Metab. 90: 2804-2809.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 2804-2809
    • Westerbacka, J.1    Lammi, K.2    Hakkinen, A.M.3
  • 6
    • 84898058711 scopus 로고    scopus 로고
    • Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
    • Kozlitina, J., and E. Smagris. 2014. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 46: 352-356.
    • (2014) Nat. Genet. , vol.46 , pp. 352-356
    • Kozlitina, J.1    Smagris, E.2
  • 7
    • 84921487729 scopus 로고    scopus 로고
    • TM6SF2 gene variant disentangles NASH from cardiovascular disease
    • Dongiovanni, P., S. Petta, C. Maglio, and A. L. Fracanzani. 2015. TM6SF2 gene variant disentangles NASH from cardiovascular disease. Hepatology. 61: 506-514.
    • (2015) Hepatology , vol.61 , pp. 506-514
    • Dongiovanni, P.1    Petta, S.2    Maglio, C.3    Fracanzani, A.L.4
  • 8
    • 84902602986 scopus 로고    scopus 로고
    • TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content
    • Mahdessian, H., A Taxiarchis, and S. Popo. 2014. TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. Proc. Natl. Acad. Sci. USA. 111:8913-8918.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 8913-8918
    • Mahdessian, H.1    Taxiarchis, A.2    Popo, S.3
  • 9
    • 85021069813 scopus 로고    scopus 로고
    • US National Library of Medicine website. Accessed December 25, 2016
    • National Center for Biotechnology Information. US National Library of Medicine website. Accessed December 25, 2016, at http://wwwncbi.nlm.nih.gov/geoprofiles.
  • 10
    • 84898058547 scopus 로고    scopus 로고
    • Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
    • Holmen, O. L., H. Zhang, and Y. Fan. 2014. Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nat. Genet. 46: 345-351.
    • (2014) Nat. Genet. , vol.46 , pp. 345-351
    • Holmen, O.L.1    Zhang, H.2    Fan, Y.3
  • 11
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • Morris, A. P., B. F. Voight, and T. M. Teslovich. 2012. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44: 981-990.
    • (2012) Nat. Genet. , vol.44 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3
  • 12
    • 84872493396 scopus 로고    scopus 로고
    • Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
    • Musso, G., R. Gambino, and M. Cassader. 2013. Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis. Prog. Lipid Res. 52: 175-191.
    • (2013) Prog. Lipid Res. , vol.52 , pp. 175-191
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 13
    • 84883817588 scopus 로고    scopus 로고
    • Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver
    • Musso, G., E. Paschetta, R. Gambino, M. Cassader, and F. Molinaro. 2013. Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver. Trends Mol. Med. 19: 522-535.
    • (2013) Trends Mol. Med. , vol.19 , pp. 522-535
    • Musso, G.1    Paschetta, E.2    Gambino, R.3    Cassader, M.4    Molinaro, F.5
  • 14
    • 84904860837 scopus 로고    scopus 로고
    • Postprandial lipemia as a cardiometabolic risk factor
    • Pirillo, A., G. D. Norata, and A. L. Catapano. 2014. Postprandial lipemia as a cardiometabolic risk factor. Curr. Med. Res. Opin. 30: 1489-1503.
    • (2014) Curr. Med. Res. Opin. , vol.30 , pp. 1489-1503
    • Pirillo, A.1    Norata, G.D.2    Catapano, A.L.3
  • 15
    • 84875459542 scopus 로고    scopus 로고
    • SREBF-2 predicts 7-year NAFLD incidence and severity of liver disease and lipoprotein and glucose dysmetabolism
    • Musso, G., M. Cassader, and S. Bo. 2013. SREBF-2 predicts 7-year NAFLD incidence and severity of liver disease and lipoprotein and glucose dysmetabolism. Diabetes. 62: 1109-1120.
    • (2013) Diabetes , vol.62 , pp. 1109-1120
    • Musso, G.1    Cassader, M.2    Bo, S.3
  • 16
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • Matsuda, M., and R A DeFronzo. 1999. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 22: 1462-1470.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 17
    • 80053449479 scopus 로고    scopus 로고
    • Genetic modifiers of non-alcoholic fatty liver disease progression
    • Anstee, Q. M., A. K. Daly, and C. P. Day. 2011. Genetic modifiers of non-alcoholic fatty liver disease progression. Biochim. Biophys. Acta. 1812: 1557-1566.
    • (2011) Biochim. Biophys. Acta. , vol.1812 , pp. 1557-1566
    • Anstee, Q.M.1    Daly, A.K.2    Day, C.P.3
  • 18
    • 0342460645 scopus 로고    scopus 로고
    • Bioimpedance analysis: Evaluation of leg-to-leg system based on pressare contact footpad electrodes
    • Nuñez, C., D. Gallagher, M. Visser, and F. X. Pi-Sunyer. 1997. Bioimpedance analysis: evaluation of leg-to-leg system based on pressare contact footpad electrodes. Med. Sci. Sports Exerc. 29: 524-531.
    • (1997) Med. Sci. Sports Exerc. , vol.29 , pp. 524-531
    • Nuñez, C.1    Gallagher, D.2    Visser, M.3    Pi-Sunyer, F.X.4
  • 19
    • 3442894221 scopus 로고    scopus 로고
    • Generalized abdominal visceral fat prediction models for black and white adults aged 17-65 y: The HERITAGE family study
    • Stanforth, P. R., A. S. Jackson, and J. S. Green. 2004. Generalized abdominal visceral fat prediction models for black and white adults aged 17-65 y: the HERITAGE family study. Int. J. Obes. Relat. Metab. Disord. 28: 925-932.
    • (2004) Int. J. Obes. Relat. Metab. Disord. , vol.28 , pp. 925-932
    • Stanforth, P.R.1    Jackson, A.S.2    Green, J.S.3
  • 20
    • 0020576146 scopus 로고
    • Calculation of substrate oxidation rates in vivo from gaseous exchange
    • Frayn, K. N. 1983. Calculation of substrate oxidation rates in vivo from gaseous exchange. J. Appl. Physiol. 55: 628-634.
    • (1983) J. Appl. Physiol. , vol.55 , pp. 628-634
    • Frayn, K.N.1
  • 21
    • 0032501738 scopus 로고    scopus 로고
    • Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men
    • Ridker, P. M., and C. H. Hennekens. 1998. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet. 351: 88-92.
    • (1998) Lancet. , vol.351 , pp. 88-92
    • Ridker, P.M.1    Hennekens, C.H.2
  • 22
    • 85027956237 scopus 로고    scopus 로고
    • Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: Multi-ethnic study of atherosclerosis
    • Vaidya, D., M. Szklo, and M. Cusman. 2011. Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosis. Eur. J. Clin. Nutr. 65: 818-825.
    • (2011) Eur. J. Clin. Nutr. , vol.65 , pp. 818-825
    • Vaidya, D.1    Szklo, M.2    Cusman, M.3
  • 23
    • 34547109615 scopus 로고    scopus 로고
    • Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests
    • Cobelli, C., G. M. Toffolo, C. Dalla Man, M. Campioni, P. Denti, A. Caumo, P. Butler, and R. Rizza. 2007. Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am. J. Physiol. Endocrinol. Metab. 293: E1-E15.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293 , pp. E1-E15
    • Cobelli, C.1    Toffolo, G.M.2    Dalla Man, C.3    Campioni, M.4    Denti, P.5    Caumo, A.6    Butler, P.7    Rizza, R.8
  • 24
    • 33846031943 scopus 로고    scopus 로고
    • Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test
    • Abdul-Ghani, M. A., M. Matsuda, and B. Balas. 2007. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care. 30: 89-94.
    • (2007) Diabetes Care , vol.30 , pp. 89-94
    • Abdul-Ghani, M.A.1    Matsuda, M.2    Balas, B.3
  • 25
    • 77955845052 scopus 로고    scopus 로고
    • Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis
    • Musso, G., R. Gambino, and M. Cassader. 2010. Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis. J. Nutr. Biochem. 21: 834-840.
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 834-840
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 26
    • 34249905859 scopus 로고    scopus 로고
    • What is the best predictor of future type 2 diabetes?
    • Abdul-Ghani, M. A., and K. Williams. 2007. What is the best predictor of future type 2 diabetes? Diabetes Care. 30: 1544-1548.
    • (2007) Diabetes Care , vol.30 , pp. 1544-1548
    • Abdul-Ghani, M.A.1    Williams, K.2
  • 27
    • 0032975814 scopus 로고    scopus 로고
    • Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects
    • Thomsen, C, O. Rasmussen, and T. Lousen. 1999. Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects. Am. J. Clin. Nutr. 69: 1135-1143.
    • (1999) Am. J. Clin. Nutr. , vol.69 , pp. 1135-1143
    • Thomsen, C.1    Rasmussen, O.2    Lousen, T.3
  • 28
    • 67650340423 scopus 로고    scopus 로고
    • Effects of peripheral administration of synthetic human GIP on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes
    • Daousi, C, J. P. Wilding, and S. Aditya. 2009. Effects of peripheral administration of synthetic human GIP on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes. Clin. Endocrinol. (Oxf.). 71: 195-201.
    • (2009) Clin. Endocrinol. (Oxf.) , vol.71 , pp. 195-201
    • Daousi, C.1    Wilding, J.P.2    Aditya, S.3
  • 29
    • 33845997750 scopus 로고    scopus 로고
    • Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure
    • Hansotia, T., A. Maida, and G. Flock. 2007. Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. J. Clin. Invest. 117: 143-152.
    • (2007) J. Clin. Invest. , vol.117 , pp. 143-152
    • Hansotia, T.1    Maida, A.2    Flock, G.3
  • 30
    • 84903207650 scopus 로고    scopus 로고
    • Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions
    • Nasteska, D., N. Harada, and K. Suzuki. 2014. Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions. Diabetes. 63: 2332-2343.
    • (2014) Diabetes , vol.63 , pp. 2332-2343
    • Nasteska, D.1    Harada, N.2    Suzuki, K.3
  • 31
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y., and Y. Hochberg. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B Stat. Methodol. 57: 289-300.
    • (1995) J. R. Stat. Soc. Series B Stat. Methodol. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 32
    • 84961922814 scopus 로고    scopus 로고
    • TM6SF2 May drive postprandial lipoprotein cholesterol toxicity away from the vessel walls to the liver in NAFLD
    • Musso, G., M. Cassader, E. Paschetta, and R. Gambino. 2016. TM6SF2 may drive postprandial lipoprotein cholesterol toxicity away from the vessel walls to the liver in NAFLD. J. Hepatol. 64: 979-981.
    • (2016) J. Hepatol. , vol.64 , pp. 979-981
    • Musso, G.1    Cassader, M.2    Paschetta, E.3    Gambino, R.4
  • 33
    • 84877064588 scopus 로고    scopus 로고
    • LDL receptors in liver: Old acquaintances and a newcomer
    • Pieper-Fürst, U., and F. Lammert. 2013. LDL receptors in liver: old acquaintances and a newcomer. Biochim. Biophys. Acta. 1831: 1191-1198.
    • (2013) Biochim. Biophys. Acta. , vol.1831 , pp. 1191-1198
    • Pieper-Fürst, U.1    Lammert, F.2
  • 34
    • 84862644868 scopus 로고    scopus 로고
    • LRP-1 modulates the proliferation and migration of human hepatic stellate cells
    • Llorente-Cortes, V., V. Barbarigo, and L. Badinon. 2012. LRP-1 modulates the proliferation and migration of human hepatic stellate cells. J. Cell. Physiol. 227: 3528-3533.
    • (2012) J. Cell. Physiol. , vol.227 , pp. 3528-3533
    • Llorente-Cortes, V.1    Barbarigo, V.2    Badinon, L.3
  • 35
    • 84892650136 scopus 로고    scopus 로고
    • VLDLR expression is a determinant factor in adipose tissue inflammation and adipocytemacrophage interaction
    • Nguyen, A., H. Tao, and M. Metrione. 2014. VLDLR expression is a determinant factor in adipose tissue inflammation and adipocytemacrophage interaction. J. Biol. Chem. 289: 1688-1703.
    • (2014) J. Biol. Chem. , vol.289 , pp. 1688-1703
    • Nguyen, A.1    Tao, H.2    Metrione, M.3
  • 36
    • 84876154662 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic VLDLR
    • Jo, H., S. s. Choe, K. C. Shin, and H. Jang. 2013. Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic VLDLR. Hepatology. 57: 1366-1377.
    • (2013) Hepatology , vol.57 , pp. 1366-1377
    • Jo, H.1    Choe, S.S.2    Shin, K.C.3    Jang, H.4
  • 37
    • 84919941318 scopus 로고    scopus 로고
    • Lipoprotein subclass metabolism in nonalcoholic steatohepatitis
    • Männistö, V. T., M. Simonen, and P. Soininen. 2014. Lipoprotein subclass metabolism in nonalcoholic steatohepatitis. J. Lipid Res. 55: 2676-2684.
    • (2014) J. Lipid Res. , vol.55 , pp. 2676-2684
    • Männistö, V.T.1    Simonen, M.2    Soininen, P.3
  • 39
    • 84874406268 scopus 로고    scopus 로고
    • Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis
    • Liu, Y, S. Turdi, and T. Park. 2013. Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis. Diabetes. 62: 743-752.
    • (2013) Diabetes , vol.62 , pp. 743-752
    • Liu, Y.1    Turdi, S.2    Park, T.3
  • 40
    • 38449111196 scopus 로고    scopus 로고
    • Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice
    • Lamont, B. J., and D.J. Drucker. 2008. Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice. Diabetes. 57: 190-198.
    • (2008) Diabetes , vol.57 , pp. 190-198
    • Lamont, B.J.1    Drucker, D.J.2
  • 41
    • 84857948775 scopus 로고    scopus 로고
    • Obstructive sleep apnea-hypopnea syndrome and nonalcoholic fatty liver disease: Emerging evidence and mechanisms
    • Musso, G., C. Olivetti, M. Cassader, and R. Gambino. 2012. Obstructive sleep apnea-hypopnea syndrome and nonalcoholic fatty liver disease: emerging evidence and mechanisms. Semin. Liver Dis. 32: 49-64.
    • (2012) Semin. Liver Dis. , vol.32 , pp. 49-64
    • Musso, G.1    Olivetti, C.2    Cassader, M.3    Gambino, R.4
  • 42
    • 84955267511 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Emerging molecular targets and therapeutic strategies
    • Musso, G., M. Cassader, and R. Gambino. 2016. Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies. Nat. Rev. Drug Discov. 15: 249-274.
    • (2016) Nat. Rev. Drug Discov. , vol.15 , pp. 249-274
    • Musso, G.1    Cassader, M.2    Gambino, R.3
  • 43
    • 85019007103 scopus 로고    scopus 로고
    • Thiazoli-dinediones and advanced liver fibrosis in nonalcoholic steatohepatitis: A meta-analysis of randomized trials
    • Epub ahead of print. February 27
    • Musso, G., M. Cassader, E. Paschetta, and R. Gambino. Thiazoli-dinediones and advanced liver fibrosis in nonalcoholic steatohepatitis: a meta-analysis of randomized trials. JAMA Intern. Med. Epub ahead of print. February 27, 2017; doi:10.1001/jamainternmed.2016.9607.
    • (2017) JAMA Intern. Med.
    • Musso, G.1    Cassader, M.2    Paschetta, E.3    Gambino, R.4


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