Analysis of the CDR3 length repertoire and the diversity of T cell receptor α and β chains in swine CD4+ and CD8+ T lymphocytes

Molecular Medicine Reports

Volumn 16, Issue 1, 2017, Pages 75-86

  Wang, Chun Yan ^a   Fang, Yong Xiang ^a   Chen, Guo Hua ^a   Jia, Huai Jie ^a   Zeng, Shuang ^a   He, Xiao Bing ^a   Feng, Yuan ^a   Li, Shou Jie ^a   Jin, Qi Wang ^a   Cheng, Wen Yu ^a   Jing, Zhi Zhong ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Complementarity determining region 3; Immunoscope spectratyping technique; T cell receptor; T cell receptor a chain; T cell receptor p chain

Indexed keywords

ANTIGEN; COMPLEMENTARITY DETERMINING REGION 3; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SELECTION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FEMALE; MINIPIG; MULTIGENE FAMILY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; DNA SEQUENCE; GENE EXPRESSION; GENE FREQUENCY; GENETIC VARIATION; GENETICS; IMMUNOLOGY; METABOLISM; PIG;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC VARIATION; MULTIGENE FAMILY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEQUENCE ANALYSIS, DNA; SWINE;

EID: 85020737389     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2017.6601     Document Type: Article

References (33)

1. Davis MM, Boniface JJ, Reich Z, Lyons D, Hampl J, Arden B and Chien Y: Ligand recognition by alpha beta T cell receptors. Ann Rev Immunol 16: 523-544, 1998.
2. Davis MM: T cell receptor gene diversity and selection. Ann Rev Biochem 59: 475-496, 1990.
3. Rowen L, Koop BF and Hood L: The complete 685-kilobase DNA sequence of the human betaT cell receptor locus. Science 272: 1755-1762, 1996.
4. Allison TJ, Winter CC, Fournie J-J, Bonneville M and Garboczi DN: Structure of a human gammadelta T-cell antigen receptor. Nature 411: 820-824, 2001.
5. Gorski J, Yassai M, Zhu X, Kissela B, Kissella B [corrected to Kissela B], Keever C and Flomenberg N: Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status. J Immunol 152: 5109-5119, 1994.
6. + T cells from individuals immunized with recombinant hepatitis B surface antigen. Clin Exp Immunol 129: 309-317, 2002.
7. Luo W, Ma L, Wen Q, Wang N, Zhou MQ and Wang XN: Analysis of the interindividual conservation of T cell receptor alpha- and beta-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol 154: 316-324, 2008.
8. Codina-Busqueta E, Scholz E, Munoz-Torres PM, Roura-Mir C, Costa M, Xufre C, Planas R, Vives-Pi M, Jaraquemada D and Marti M: TCR bias of in vivo expanded T cells in pancreatic islets and spleen at the onset in human type 1 diabetes. J Immunol 186: 3787-3797, 2011.
9. Kitaura K, Fujii Y, Hayasaka D, Matsutani T, Shirai K, Nagata N, Lim CK, Suzuki S, Takasaki T, Suzuki R and Kurane I: High clonality of virus-specific T lymphocytes defined by TCR usage in the brains of mice infected with West Nile virus. J Immunol 187: 3919-3930, 2011.
10. Gonzalez-Serna A, Abad-Fernandez M, Soriano-Sarabia N, Leal M and Vallejo A: CD8 TCR p chain repertoire expansions and deletions are related with immunologic markers in HIV-1-infected patients during treatment interruption. J Clin Virol 58: 703-709, 2013.
11. Maru Y, Yokosuka O, Imazeki F, Saisho H and Omata M: Analysis of T cell receptor variable regions and complementarity determining region 3 of infiltrating T lymphocytes in the liver of patients with chronic type B hepatitis. Intervirology 46: 277-288, 2003.
12. Gras S, Wilmann PG, Chen Z, Halim H, Liu YC, Kjer-Nielsen L, Purcell AW, Burrows SR, McCluskey J and Rossjohn J: A structural basis for varied ap TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule. J Immunol 188: 311-321, 2012.
13. Rezvany M-R, Jeddi-Tehrani M, Wigzell H, Osterborg A and Mellstedt H: Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia. Blood 101: 1063-1070, 2003.
14. Luo W, Liao WJ, Huang YT, Shi M, Zhang Y, Wen Q, Zhou MQ and Ma L: Normalization of T cell receptor repertoire diversity in patients with advanced colorectal cancer who responded to chemotherapy. Cancer Sci 102: 706-712, 2011.
15. Hirokawa M, Matsutani T, Saitoh H, Ichikawa Y, Kawabata Y, Horiuchi T, Kitabayashi A, Yoshioka T, Tsuruta Y, Suzuki R, et al: Distinct TCRAV and TCRBV repertoire and CDR3 sequence of T lymphocytes clonally expanded in blood and GVHD lesions after human allogeneic bone marrow transplantation. Bone Marrow Transplant 30: 915-923, 2002.
16. Gorski J, Yassai M, Keever C and Flomenberg N: Analysis of reconstituting T cell receptor repertoires in bone marrow transplant recipients. Arch Immunol Ther Exp (Warsz) 43: 93-97, 1995.
17. Kim G, Tanuma N and Matsumoto Y: Stage-dependent usage of TCR alpha chains with different CDR3 motifs by spinal cord T cells in autoimmune encephalomyelitis. J Neuroimmunol 96: 66-72, 1999.
18. Gianello P, Fishbein JM and Sachs DH: Tolerance to primarily vascularized allografts in miniature swine. Immunol Rev 133: 19-44, 1993.
19. Yao WJ, Fang YX, Jia HJ, He XB, Zeng S, Chen GH, Liu TA and Jing ZZ: Diversity and molecular genetic characteristics of porcine T cell receptor 0 chain. Vet Sci Chi 44: 641-649, 2014.
20. Yamamoto R, Uenishi H, Hatsuse H, Sato E, Awata T, Yasue H and Takagaki Y: TRAV gene usage in pig T-cell receptor alpha cDNA. Immunogenetics 57: 219-225, 2005.
21. Baron C, Sachs DH and LeGuern C: A particular TCR beta variable region used by T cells infiltrating kidney transplants. J Immunol 166: 2589-2596, 2001.
22. Butler JE, Wertz N, Sun J and Sacco RE: Comparison of the expressed porcine Vbeta and Jbeta repertoire of thymocytes and peripheral T cells. Immunology 114: 184-193, 2005.
23. Watanabe M, Iwasaki Y, Mita Y, Ota S, Yamada S, Shimuzu M and Takagaki Y: Porcine T-cell receptor beta-chain: A genomic sequence covering Dbeta1. 1 to Cbeta2 gene segments and the diversity of cDNA expressed in piglets including novel alternative splicing products. Mol Immunol 44: 2332-2343, 2007.
24. Eguchi-Ogawa T, Toki D and Uenishi H: Genomic structure of the whole D-J-C clusters and the upstream region coding V segments of the TRB locus in pig. Dev Comp Immunol 33: 1111-1119, 2009.
25. Li T, He X, Jia H, Chen G, Zeng S, Fang Y, Jin Q and Jing Z: Molecular cloning and functional characterization of murine toll-like receptor 8. Mol Med Rep 13: 1119-1126, 2016.
26. Chen G, Zeng S, Jia H, He X, Fang Y, Jing Z and Cai X: Adjuvant effect enhancement of porcine interleukin-2 packaged into solid lipid nanoparticles. Res Vet Sci 96: 62-68, 2014.
27. Luo W, Liao WJ, Ma L, Huang YT, Shi M, Wen Q and Wang XN: Dynamic monitoring the TCR CDR3 spectratypes in patients with metastatic CRC treated with a combination of bevacizumab, irinotecan, fluorouracil, and leucovorin. Cancer Immunol Immu-nother 59: 247-256, 2010.
28. Yao WJ: Dynamic changes of T cell receptor a and 0 chain variable regions in the peripheral blood mononuclear cells of the infected pigs by C-strain classical swine fever virus (unpublished PhD thesis). Chinese Academy of Agricultural Sciences, 2014.
29. Fazilleau N, Cabaniols JP, Lemaitre F, Motta I, Kourilsky P and Kanellopoulos JM: Valpha and Vbeta public repertoires are highly conserved in terminal deoxynucleotidyl transferase-deficient mice. J Immunol 174: 345-355, 2005.
30. Yao XS, Diao Y, Sun WB, Luo JM, Qin M and Tang XY: Analysis of the CDR3 length repertoire and the diversity of TCR alpha chain in human peripheral blood T lymphocytes. Cell Mol Immunol 4: 215-220, 2007.
31. Nemazee D: Receptor editing in lymphocyte development and central tolerance. Nat Rev Immunol 6: 728-740, 2006.
32. Nishio J, Suzuki M, Nanki T, Miyasaka N and Kohsaka H: Development of TCRB CDR3 length repertoire of human T lymphocytes. Int Immunol 16: 423-431, 2004.
33. Pannetier C, Cochet M, Darche S, Casrouge A, Zoller M and Kourilsky P: The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci USA 90: 4319-4323, 1993.