Retrospective survey of mcr-1 and mcr-2 in German pig-fattening farms, 2011–2012

International Journal of Antimicrobial Agents

Volumn 50, Issue 2, 2017, Pages 266-271

  Roschanski, Nicole ^a   Falgenhauer, Linda ^b   Grobbel, Mirjam ^c   Guenther, Sebastian ^a   Kreienbrock, Lothar ^d   Imirzalioglu, Can ^b   Roesler, Uwe ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^d UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Antibiotics; Livestock; Multidrug resistance

Indexed keywords

CEPHALOSPORIN; COLISTIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ANTIINFECTIVE AGENT; ESCHERICHIA COLI PROTEIN; MCR-1 PROTEIN, E COLI;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; BACTERIUM ISOLATE; CONTROLLED STUDY; ESCHERICHIA COLI; FECES CULTURE; GENETIC HETEROGENEITY; GERMANY; HUMAN; MCR 1 GENE; MCR 2 GENE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PIG FARMING; PLASMID; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RETROSPECTIVE STUDY; VETERINARY CLINIC; AGRICULTURAL LAND; ANALYSIS; ANIMAL; CLASSIFICATION; DRUG EFFECTS; FECES; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR TYPING; PIG;

ANIMALS; ANTI-BACTERIAL AGENTS; COLISTIN; ELECTROPHORESIS, GEL, PULSED-FIELD; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FARMS; FECES; GERMANY; MICROBIAL SENSITIVITY TESTS; MOLECULAR TYPING; PLASMIDS; RETROSPECTIVE STUDIES; SWINE;

EID: 85020675107     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2017.03.007     Document Type: Article

References (25)

1. European Centre for Disease Prevention and Control, Summary of the latest data on antibiotic consumption in the European Union. 2015, ECDC, Solna (Sweden).
2. Falagas, M.E., Kasiakou, S.K., Colistin: the revival of polymyxins for the management of multidrug-resistant Gram-negative bacterial infections. Clin Infect Dis 40 (2005), 1333–1341.
3. European Medicines Agency, Updated advice on the use of colistin products in animals within the European Union: development of resistance and possible impact on human and animal health. 2016, EMA, London (UK) EMA/231573/2016.
4. Liu, Y.Y., Wang, Y., Walsh, T.R., Yi, L.X., Zhang, R., Spencer, J., et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16 (2016), 161–168.
5. Schwarz, S., Johnson, A.P., Transferable resistance to colistin: a new but old threat. J Antimicrob Chemother 71 (2016), 2066–2070.
6. Xavier, B.B., Lammens, C., Ruhal, R., Kumar-Singh, S., Butaye, P., Goossens, H., et al. Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016. Euro Surveill, 21, 2016, 10.2807/1560-7917.ES.2016.21.27.30280.
7. Falgenhauer, L., Waezsada, S.E., Yao, Y., Imirzalioglu, C., Kasbohrer, A., Roesler, U., et al. Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany. Lancet Infect Dis 16 (2016), 282–283.
8. Yu, H., Qu, F., Shan, B., Huang, B., Jia, W., Chen, C., et al. Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China. Antimicrob Agents Chemother 60 (2016), 5033–5035.
9. NDM-5, causing a complicated urinary tract infection in a patient from the United States. MBio, 7, 2016 pii: e01191-16.
10. Hering, J., Hille, K., Fromke, C., von Munchhausen, C., Hartmann, M., Schneider, B., et al. Prevalence and potential risk factors for the occurrence of cefotaxime resistant Escherichia coli in German fattening pig farms—a cross-sectional study. Prev Vet Med 116 (2014), 129–137.
11. von Salviati, C., Friese, A., Roschanski, N., Laube, H., Guerra, B., Kasbohrer, A., et al. Extended-spectrum β-lactamases (ESBL)/AmpC β-lactamases-producing Escherichia coli in German fattening pig farms: a longitudinal study. Berl Munch Tierarztl Wochenschr 127 (2014), 412–419.
12. Roschanski, N., Fischer, J., Guerra, B., Roesler, U., Development of a multiplex real-time PCR for the rapid detection of the predominant β-lactamase genes CTX-M, SHV, TEM and CIT-type AmpCs in Enterobacteriaceae. PLoS ONE, 9, 2014 e100956.
13. Irrgang, A., Roschanski, N., Tenhagen, B.A., Grobbel, M., Skladnikiewicz-Ziemer, T., Thomas, K., et al. Prevalence of mcr-1 in E. coli from livestock and food in Germany, 2010–2015. PLoS ONE, 11, 2016 e0159863.
14. Clermont, O., Christenson, J.K., Denamur, E., Gordon, D.M., The Clermont Escherichia coli phylo-typing method revisited: improvement of specificity and detection of new phylo-groups. Environ Microbiol Rep 5 (2013), 58–65.
15. Clinical and Laboratory Standards Institute, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard—10th edition. Document M07-A10, 2015, CLSI, Wayne (PA).
16. European Committee on Antimicrobial Susceptibility Testing, Breakpoint tables for interpretation of MICs and zone diameters. Version 6.0, 2016. 2016, EUCAST, Växjö (Switzerland).
17. Bankevich, A., Nurk, S., Antipov, D., Gurevich, A.A., Dvorkin, M., Kulikov, A.S., et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol 19 (2012), 455–477.
18. Zankari, E., Hasman, H., Cosentino, S., Vestergaard, M., Rasmussen, S., Lund, O., et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother 67 (2012), 2640–2644.
19. Carattoli, A., Zankari, E., Garcia-Fernandez, A., Larsen, M.V., Lund, O., Villa, L., et al. In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing. Antimicrob Agents Chemother 58 (2014), 3895–3903.
20. Larsen, M.V., Cosentino, S., Rasmussen, S., Friis, C., Hasman, H., Marvig, R.L., et al. Multilocus sequence typing of total-genome-sequenced bacteria. J Clin Microbiol 50 (2012), 1355–1361.
21. Fernandes, M.R., McCulloch, J.A., Vianello, M.A., Moura, Q., Perez-Chaparro, P.J., Esposito, F., et al. First report of the globally disseminated IncX4 plasmid carrying the mcr-1 gene in a colistin-resistant Escherichia coli sequence type 101 isolate from a human infection in Brazil. Antimicrob Agents Chemother 60 (2016), 6415–6417.
22. Alikhan, N.F., Petty, N.K., Ben Zakour, N.L., Beatson, S.A., BLAST ring image generator (BRIG): simple prokaryote genome comparisons. BMC Genomics, 12, 2011, 402.
23. van Rennings, L., von Munchhausen, C., Ottilie, H., Hartmann, M., Merle, R., Honscha, W., et al. Cross-sectional study on antibiotic usage in pigs in Germany. PLoS ONE, 10, 2015 e0119114.
24. Guenther, S., Falgenhauer, L., Semmler, T., Imirzalioglu, C., Chakraborty, T., Roesler, U., et al. Environmental emission of multiresistant Escherichia coli carrying the colistin resistance gene mcr-1 from German swine farms. J Antimicrob Chemother, 2017, 10.1093/jac/dkw585 Epub ahead of print.
25. European Medicines Agency, Countries should reduce use of colistin in animals to decrease the risk of antimicrobial resistance. 2016, EMA, London (UK) EMA/480583/2016.