Defining and measuring suspicion of sepsis: An analysis of routine data

BMJ Open

Volumn 7, Issue 6, 2017, Pages

  Inada Kim, Matthew ^a   Page, Bethan ^b   Maqsood, Imran ^c   Vincent, Charles ^b  

^a ROYAL HAMPSHIRE COUNTY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c BD Bioscience Oxford Science Park   (United Kingdom)

Author keywords

epidemiology; improvement programmes; sepsis; suspicion of sepsis

Indexed keywords

ADULT; ARTICLE; FEMALE; HOSPITAL ADMISSION; HOSPITAL MORTALITY; HOSPITAL READMISSION; HUMAN; ICD-10; LOBAR PNEUMONIA; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; OUTCOME ASSESSMENT; PATIENT CODING; PRACTICE GUIDELINE; RETROSPECTIVE STUDY; SECONDARY HEALTH CARE; SEPSIS; SUSPICION OF SEPSIS; URINARY TRACT INFECTION; ADOLESCENT; AGED; COMPLICATION; FACTUAL DATABASE; INCIDENCE; INTERNATIONAL CLASSIFICATION OF DISEASES; MIDDLE AGED; MORTALITY; PNEUMONIA; RISK ASSESSMENT; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DATABASES, FACTUAL; FEMALE; HUMANS; INCIDENCE; INTERNATIONAL CLASSIFICATION OF DISEASES; MALE; MIDDLE AGED; PATIENT ADMISSION; PNEUMONIA; PRACTICE GUIDELINES AS TOPIC; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SEPSIS; URINARY TRACT INFECTIONS; YOUNG ADULT;

EID: 85020636108     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2016-014885     Document Type: Article

References (31)

1. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 2016;315:801-10.
2. Xu J, Kenneth D, Kochanek MA, et al. Deaths: final data for 2007. National Vital Statistics Reports 2010;58.
3. Elixhauser A, Friedman B, Stranges E. Septicemia in US hospitals, 2009: Statistical Brief #122. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet] 2011.
4. Harrison DA, Welch CA, Eddleston JM. The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC case mix programme database. Crit Care 2006;10:R42.
5. Health and Social Care Information Centre. Hospital episode statistics. 2015 http://www.hscic.gov.uk/media/19070/Sepsisannual-data-inpatient-measures/xls/Sepsis-annual-data-inpatient-measures-(1).xlsx (accessed 3 Mar 2016).
6. Dombrovskiy VY, Martin AA, Sunderram J, et al. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007;35:1244-50.
7. Kumar G, Kumar N, Taneja A, et al. Nationwide trends of severe sepsis in the 21st century (2000-2007). Chest 2011;140:1223-31.
8. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-10.
9. Torio CM, Andrews RM. National inpatient hospital costs: the most expensive conditions by payer. 2011;160. Statistical brief no. https://www.hcup-us.ahrq.gov/reports/statbriefs/sb160.jsp
10. Winters BD, Eberlein M, Leung J, et al. Long-term mortality and quality of life in sepsis: a systematic review. Crit Care Med 2010;38:1276-83.
11. Prescott HC, Osterholzer JJ, Langa KM, et al. Late mortality after sepsis: propensity matched cohort study. BMJ 2016;353:i2375.
12. NCEPOD. Just say sepsis! A review of the process of care received by patients with sepsis. 2015 http://www.ncepod.org.uk/2015report2/downloads/JustSaySepsis-FullReport.pdf (accessed 1 Feb 2016).
13. England NHS. Improving outcomes for patients with sepsis. 2015 https://www.england.nhs.uk/wp-content/uploads/2015/08/Sepsis-Action-Plan-23.12.15-v1.pdf
14. Parliamentary and Health Service Ombudsman. Time to act: severe sepsis: rapid diagnosis and treatment saves lives. http://www.ombudsman.org.uk/data/assets/pdf-file/0004/22666/FINAL-Sepsis-Report-web.pdf 2013 (accessed 20 May 2016).
15. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013;39:165-228.
16. England NHS. Commissioning for Quality and Innovation (CQUIN) Guidance for 2015/16. https://www.england.nhs.uk/wp-content/uploads/2015/03/9-cquin-guid-2015-16.pdf (accessed 17 Feb 2016).
17. Rhee C, Gohil S, Klompas M. Regulatory mandates for sepsis care-reasons for caution. N Engl J Med 2014;370:1673-6.
18. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699-709.
19. Phua J, Ngerng W, See K, et al. Characteristics and outcomes of culture-negative versus culture-positive severe Sepsis. Crit Care 2013;17:R202.
20. Vincent JL, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006;34:344-53.
21. Alberti C, Brun-Buisson C, Burchardi H, et al. Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med 2002;28:108-21.
22. Jolley RJ, Sawka KJ, Yergens DW, et al. Validity of administrative data in recording sepsis: a systematic review. Crit Care 2015;19:139.
23. Wilhelms SB, Huss FR, Granath G, et al. Assessment of incidence of severe sepsis in Sweden using different ways of abstracting International classification of diseases codes: difficulties with methods and interpretation of results. Crit Care Med 2010;38:1442-9.
24. Rhee C, Murphy MV, Li L, et al. Comparison of trends in sepsis incidence and coding using administrative claims versus objective clinical data. Clin Infect Dis 2015;60:88-95.
25. Cohen J, Vincent JL, Adhikari NK, et al. Sepsis: a roadmap for future research. Lancet Infect Dis 2015;15:581-614.
26. National Institute for Health and Care Excellence (NICE). Sepsis: recognition, diagnosis and early management 2016 https://www.nice.org.uk/guidance/ng51 (accessed 15 Sept 2016).
27. Freitag A, Constanti M, O'Flynn N, et al. Suspected sepsis: summary of NICE guidance. BMJ 2016;354:i4030.
28. Danai P, Martin GS. Epidemiology of sepsis: recent advances. Curr Infect Dis Rep 2005;7:329-34.
29. Martin GS. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther 2012;10:701-6.
30. Esteban A, Frutos-Vivar F, Ferguson ND, et al. Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward. Crit Care Med 2007;35:1284-9.
31. Rhee C, Kadri SS, Danner RL, et al. Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes. Crit Care 2016;20:89.