Aging, Smooth Muscle Vitality, and Aortic Integrity

Circulation Research

Volumn 120, Issue 12, 2017, Pages 1849-1851

  Humphrey, Jay D ^a   Milewicz, Dianna M ^b  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

actomyosin activity; apoptosis; ATP; Editorials; inflammation; mechanotransduction

Indexed keywords

ADENOSINE TRIPHOSPHATE; MYOSIN LIGHT CHAIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE NUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 1;

AGING; AORTA; AORTIC DISEASE; AORTIC MEDIA; AORTIC WALL; ARTERY DILATATION; CELL METABOLISM; HEART MUSCLE CONTRACTILITY; HUMAN; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE; THORACIC AORTA ANEURYSM; VASCULAR SMOOTH MUSCLE CELL; SMOOTH MUSCLE CELL;

AORTA; AORTIC ANEURYSM, THORACIC; HUMANS; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE;

EID: 85020629946     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.311075     Document Type: Review

References (15)

1. Najjar SS, Scuteri A, Lakatta EG. Arterial aging: is it an immutable cardiovascular risk factor? Hypertension. 2005; 46: 454-462. doi: 10. 1161/01. HYP. 0000177474. 06749. 98.
2. Humphrey JD, Schwartz MA, Tellides G, Milewicz DM. Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections. Circ Res. 2015; 116: 1448-1461. doi: 10. 1161/ CIRCRESAHA. 114. 304936.
3. Ying W. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal. 2008; 10: 179-206. doi: 10. 1089/ars. 2007. 1672.
4. Wang P, Li WL, Liu JM, Miao CY. NAMPT and NAMPT-controlled NAD metabolism in vascular repair. J Cardiovasc Pharmacol. 2016; 67: 474-481. doi: 10. 1097/FJC. 0000000000000332.
5. Watson A, Nong Z, Yin H, O'Neil C, Fox S, Balint B, Guo L, Leo O, Chu MWA, Gros R, Pickering JG. Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aneurysm disease. Circ Res. 2017; 120: 1889-1902. doi: 10. 1161/ CIRCRESAHA. 116. 310022.
6. Li W, Li Q, Jiao Y, Qin L, Ali R, Zhou J, Ferruzzi J, Kim RW, Geirsson A, Dietz HC, Offermanns S, Humphrey JD, Tellides G. Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. J Clin Invest. 2014; 124: 755-767. doi: 10. 1172/JCI69942.
7. Roccabianca S, Ateshian GA, Humphrey JD. Biomechanical roles of medial pooling of glycosaminoglycans in thoracic aortic dissection. Biomech Model Mechanobiol. 2014; 13: 13-25. doi: 10. 1007/s10237-013-0482-3.
8. van der Veer E, Nong Z, O'Neil C, Urquhart B, Freeman D, Pickering JG. Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation. Circ Res. 2005; 97: 25-34. doi: 10. 1161/01. RES. 0000173298. 38808. 27.
9. Emrich FC, Okamura H, Dalal AR, et al. Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome. Arterioscler Thromb Vasc Biol. 2015; 35: 146-154. doi: 10. 1161/ATVBAHA. 114. 304364.
10. Kuang SQ, Medina-Martinez O, Guo DC, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016; 126: 948-961. doi: 10. 1172/JCI83778.
11. He R, Guo DC, Estrera AL, Safi HJ, Huynh TT, Yin Z, Cao SN, Lin J, Kurian T, Buja LM, Geng YJ, Milewicz DM. Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections. J Thorac Cardiovasc Surg. 2006; 131: 671-678. doi: 10. 1016/j. jtcvs. 2005. 09. 018.
12. de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai S, Seals DR. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016; 15: 522-530. doi: 10. 1111/acel. 12461.
13. Fry JL, Shiraishi Y, Turcotte R, Yu X, Gao YZ, Akiki R, Bachschmid M, Zhang Y, Morgan KG, Cohen RA, Seta F. Vascular smooth muscle sirtuin-1 protects against aortic dissection during angiotensin II-induced hypertension. J Am Heart Assoc. 2015; 4: e002384. doi: 10. 1161/ JAHA. 115. 002384.
14. Milewicz DM, Trybus KM, Guo DC, Sweeney HL, Regalado E, Kamm K, Stull JT. Altered smooth muscle cell force generation as a driver of thoracic aortic aneurysms and dissections. Arterioscler Thromb Vasc Biol. 2017; 37: 26-34. doi: 10. 1161/ATVBAHA. 116. 303229.
15. McCrudden CM, O'Rourke MG, Cherry KE, et al. Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself. PLoS One. 2015; 10: e0118187. doi: 10. 1371/journal. pone. 0118187.