SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

Microfluidics and Nanofluidics

Volumn 21, Issue 6, 2017, Pages

  Domansky, Karel ^a,d   Sliz, Josiah D ^a,e   Wen, Norman ^a,e   Hinojosa, Christopher ^a,e   Thompson, Guy ^a,e   Fraser, Jacob P ^a,e   Hamkins Indik, Tiama ^a   Hamilton, Geraldine A ^a,e   Levner, Daniel ^a,e   Ingber, Donald E ^a,b,c  

^a HARVARD UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d Emulate Inc ^*  (United States)

^e Emulate Inc   (United States)

Author keywords

Injection molding; Microfluidic device; Organ on a chip (Organ Chip); SEBS; Thermoplastic elastomer

Indexed keywords

BLOCK COPOLYMERS; BOND (MASONRY); CELL CULTURE; ELASTOMERS; ETHYLENE; EXTRUSION; EXTRUSION MOLDING; FABRICATION; FLUIDIC DEVICES; HYDROPHOBICITY; MICROCHANNELS; MICROFLUIDICS; MOLDING; PLASTICS; POLYDIMETHYLSILOXANE; SILICONES; STYRENE; THERMOPLASTIC ELASTOMERS;

HIGH VOLUME MANUFACTURING; HYDROPHOBIC MOLECULES; MICRO-FLUIDIC DEVICES; ORGAN-ON-A-CHIP (ORGAN CHIP); POLYDIMETHYLSILOXANE POLYMERS; SEBS; STYRENE ETHYLENE BUTYLENE STYRENES; STYRENIC BLOCK COPOLYMERS;

INJECTION MOLDING;

EID: 85020517898     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-017-1941-4     Document Type: Article

References (35)

1. Bhatia SN, Ingber DE (2014) Microfluidic organs-on-chips. Nat Biotechnol 32:760–772. doi:10.1038/nbt.2989
2. Boonchareon W, Apisittinet S, Sirikittikul D, Loykulnant S, Fuougfuchat A, Ritvirulh C, Sooknoi T (2007) Structure and Gas Selectivity of PE/Zeolite composite film. In: The 2nd international conference on advanced in petrochemicals and polymers (ICAPP 2007), Bangkok
3. Borysiak MD, Bielawski K, Sniadecki NJ, Jenkel CF, Vogt BD, Posner JD (2013) Simple replica micromolding of biocompatible styrenic elastomers. Lab Chip 13:2773–2784. doi:10.1039/C3LC50426C
4. Brassar D, Clime L, Li K, Geissler M, Miville-Godin C, Roy E, Veres T (2011) 3D thermoplastic elastomer microfluidic devices for biological probe immobilization. Lab Chip 11:4099–4107. doi:10.1039/c1lc20714h
5. Domansky K et al (2013) Clear castable polyurethane elastomer for fabrication of microfluidic devices. Lab Chip 13:3956–3964. doi:10.1039/c3lc50558h
6. Drobny JG (2014) Handbook of thermoplastic elastomers. In: Plastics design library, 2nd edn. Elsevier, Amsterdam, Netherlands
7. Fang L, Wei M, Shang Y, Jimenez L, Kazmer D, Barry C, Mead J (2009) Surface morphology alignment of block copolymers induced by injection molding. Polymer 50:5837–5845. doi:10.1016/j.polymer.2009.09.013
8. Guillemette MD, Roy E, Auger FA, Veres T (2011) Rapid isothermal substrate microfabrication of a biocompatible thermoplastic elastomer for cellular contact guidance. Acta Biomater 7:2492–2498. doi:10.1016/j.actbio.2011.02.019
9. Heo YS, Cabrera LM, Song JW, Futai N, Tung Y-C, Smith GD, Takayama S (2007) Characterization and resolution of evaporation-mediated osmolality shifts that constrain microfluidic cell culture in poly(dimethylsiloxane) devices. Anal Chem 79:1126–1134. doi:10.1021/ac061990v
10. Houston KS, Weinkauf DH, Stewart FF (2002) Gas transport characteristics of plasma treated poly (dimethylsiloxane) and polyphosphazene membrane materials. J Membr Sci 205:103–112. doi:10.1016/s0376-7388(02)00068-6
11. Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE (2010) Reconstituting organ-level lung functions on a chip. Science 328:1662–1668. doi:10.1126/science.1188302
12. Huh D et al (2013) Microfabrication of human organs-on-chips. Nat Protoc 8:2135–2157
13. Kang D, Matsuki S, Tai Y-C (2015) Study of the hybrid parylene/PDMS material. In: 28th IEEE international conference on micro electro mechanical systems (MEMS 2015), Estoril, Portugal, IEEE, pp 397–400
14. Keller A, Pedemont E, Willmout Fm (1970) Macro-lattice from segregated amorphous phases of a 3 block copolymer. Nature 225:538. doi:10.1038/225538a0
15. Kim HJ, Huh D, Hamilton G, Ingber DE (2012) Human gut-on-a-chip inhabited by microbial flora that experiences peristalsis-like motions and flow. Lab Chip 12:2165–2174. doi:10.1039/c2lc40074j
16. Kim M, Lam RHW, Thorsen T, Asada HH (2013) Mathematical analysis of oxygen transfer through polydimethylsiloxane membrane between double layers of cell culture channel and gas chamber in microfluidic oxygenator. Microfluid Nanofluid 15:285–296. doi:10.1007/s10404-013-1142-8
17. Lamberti A, Marasso SL, Cocuzza M (2014) PDMS membranes with tunable gas permeability for microfluidic applications. Rsc Adv 4:61415–61419. doi:10.1039/c4ra12934b
18. Lee HH, Register RA, Hajduk DA, Gruner SM (1996) Orientation of triblock copolymers in planar extension. Polym Eng Sci 36:1414–1424. doi:10.1002/pen.10536
19. Merkel TC, Bondar VI, Nagai K, Freeman BD, Pinnau I (2000) Gas sorption, diffusion, and permeation in poly(dimethylsiloxane). J Polym Sci Part B: Polym Phys 38:415–434
20. Monprasit P, Ritvirulh C, Sooknoi T, Rukchonlatee S, Fuongfuchat A, Sirikittikul D (2011) Selective ethylene-permeable zeolite composite Double-layered film for novel modified atmosphere packaging. Polym Eng Sci 51:1264–1272. doi:10.1002/pen.21924
21. Panaitescu DM, Gabor RA, Nicolae CA, Ghiurea M, Mihailescu M, Grigorescu RM (2014) Influence of melt processing induced orientation on the morphology and mechanical properties of poly(styrene-b-ethylene/butylene-b-styrene) block copolymers and their composites with graphite. Mater Des 64:694–705. doi:10.1016/j.matdes.2014.08.049
22. Park J, Na S, Kang M, Sim S, Jeon N (2017) PDMS microchannel surface modification with Teflon for algal lipid research BioChip published online 03 March 2017, DOI: 10.1007/s13206-017-1302-0
23. Regehr KJ et al (2009) Biological implications of polydimethylsiloxane-based microfluidic cell culture. Lab Chip 9:2132–2139. doi:10.1039/b903043c
24. Robb WL (1968) Thin silicone membranes–their permeation properties and some applications. Ann N Y Acad Sci 146:119–137. doi:10.1111/j.1749-6632.1968.tb20277.x
25. Roy E, Galas J-C, Veres T (2011a) Thermoplastic elastomers for microfluidics: towards a high-throughput fabrication method of multilayered microfluidic devices. Lab Chip 11:3193–3196. doi:10.1039/c1lc20251k
26. Roy E, Geissler M, Galas J-C, Veres T (2011b) Prototyping of microfluidic systems using a commercial thermoplastic elastomer. Microfluid Nanofluidics 11:235–244. doi:10.1007/s10404-011-0789-2
27. Sakurai S (2008) Progress in control of microdomain orientation in block copolymers—efficiencies of various external fields. Polymer 49:2781–2796. doi:10.1016/j.polymer.2008.03.020
28. Sasaki H, Onoe H, Takeuchi S (2010) Parylene-coating in PDMS microfluidic channels prevents the absorption of fluorescent dyes Sensors and Actuators B. Chemical 150:478–482
29. Shirure V, George S (2017) Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms. Lab Chip 17:681–690. doi:10.1039/C6LC01401A
30. Sipkens K (2000) SEBS-based compounds. Med Device Technol 11:8–13
31. Sudarsan AP, Wang J, Ugaz VM (2004) Novel thermoplastic elastomers for microfluidic device construction. In: Laurell T, Nilsson J, Jensen K, Harrison DJ, Kutter JP (eds) 8th international conference on miniaturized systems for chemictry and life science (MicroTAS). The Royal Society of Chemistry, Malmo, pp 22–24
32. Sudarsan AP, Wang J, Ugaz VM (2005) Microfabrication of 3D structures using novel thermoplastic elastomers. In: NSTI nanotechnology conference and trade show, Anaheim pp 523–525
33. Sudarsan AP, Wang J, Ugaz VM (2005b) Thermoplastic elastomer gels: an advanced substrate for microfluidic chemical analysis systems. Anal Chem 77:5167–5173. doi:10.1021/ac050448o
34. Toepke MW, Beebe DJ (2006) PDMS absorption of small molecules and consequences in microfluidic applications. Lab Chip 6:1484–1486. doi:10.1039/b612140c
35. van Meer B et al (2017) Small molecule absorption by PDMS in the context of drug response bioassays. Biochem Biophys Res Commun 482:323–328. doi:10.1016/j.bbrc.2016.11.062