Cell Cycle-Dependent Kinase Cdk9 Is a Postexposure Drug Target against Human Adenoviruses

ACS Infectious Diseases

Volumn 3, Issue 6, 2017, Pages 398-405

  Prasad, Vibhu ^a   Suomalainen, Maarit ^a   Hemmi, Silvio ^a   Greber, Urs F ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

antiviral compound; C5; D37; D8; epidemic keratoconjunctivitis (EKC); flavopiridol; host directed antiviral compound; human adenovirus types C2; impedance xCELLigence

Indexed keywords

CYCLIN DEPENDENT KINASE 9; E1A PROTEIN; FLAVOPIRIDOL; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; TELOMERASE REVERSE TRANSCRIPTASE; VIRUS DNA; ANTIVIRUS AGENT; CDK9 PROTEIN, HUMAN; FLAVONOID; PIPERIDINE DERIVATIVE; SMALL INTERFERING RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CYCLE PROGRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORNEA EPITHELIUM; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG EXPOSURE; DRUG TARGETING; ENZYME INHIBITION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HELA CELL LINE; HUMAN; HUMAN ADENOVIRUS 2; HUMAN ADENOVIRUS 5; HUMAN ADENOVIRUS C; HUMAN ADENOVIRUS D37; HUMAN ADENOVIRUS D8; HUMAN ADENOVIRUS INFECTION; HUMAN CELL; IN VITRO STUDY; KERATOCONJUNCTIVITIS; M PHASE CELL CYCLE CHECKPOINT; NONHUMAN; NUCLEAR IMPORT; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RNA INTERFERENCE; S PHASE CELL CYCLE CHECKPOINT; THERAPEUTIC INDEX; TITRIMETRY; TRANSACTIVATION; TRANSCRIPTION ELONGATION; VIRAL PLAQUE ASSAY; VIRUS CAPSID; VIRUS ENTRY; VIRUS GENOME; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CYCLE; CELL LINE; CORNEA; DOSE RESPONSE; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; PATHOLOGY; VIROLOGY;

ADENOVIRUS E1A PROTEINS; ADENOVIRUSES, HUMAN; ANTIVIRAL AGENTS; CELL CYCLE; CELL LINE; CORNEA; CYCLIN-DEPENDENT KINASE 9; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FLAVONOIDS; GENE EXPRESSION REGULATION; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; PIPERIDINES; RNA, SMALL INTERFERING;

EID: 85020397228     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.7b00009     Document Type: Article

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