A systematic review and meta-analysis of the effect of prophylactic tranexamic acid treatment in major benign uterine surgery

International Journal of Gynecology and Obstetrics

Volumn 136, Issue 2, 2017, Pages 120-127

  Topsoee, Märta F ^a   Settnes, Annette ^a   Ottesen, Bent ^a   Bergholt, Thomas ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Antifibrinolytic agent; Antifibrinolytic therapy; Bleeding prophylaxis; Obstetric and gynecologic surgery; Surgical bleeding; Tranexamic acid

Indexed keywords

TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

BLOOD TRANSFUSION; CESAREAN SECTION; CLINICAL OUTCOME; ELECTIVE SURGERY; HUMAN; MAJOR SURGERY; META ANALYSIS; MYOMECTOMY; OPERATIVE BLOOD LOSS; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; THERAPY EFFECT; UTERUS SURGERY; BLOOD LOSS, SURGICAL; FEMALE; GYNECOLOGIC SURGERY; PREGNANCY; STATISTICS AND NUMERICAL DATA;

ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; CESAREAN SECTION; FEMALE; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRANEXAMIC ACID;

EID: 85020374420     PISSN: 00207292     EISSN: 18793479     Source Type: Journal    
DOI: 10.1002/ijgo.12047     Document Type: Review

References (40)

1. McPherson K, Metcalfe MA, Herbert A, et al. Severe complications of hysterectomy: The VALUE study. BJOG. 2004;111:688–694.
2. Clarke-Pearson DL, Geller EJ. Complications of hysterectomy. Obstet Gynecol. 2013;121:654–673.
3. Butwick AJ, Carvalho B, El-Sayed YY. Risk factors for obstetric morbidity in patients with uterine atony undergoing caesarean delivery. Br J Anaesth. 2014;113:661–668.
4. Makinen J, Brummer T, Jalkanen J, et al. Ten years of progress - improved hysterectomy outcomes in Finland 1996-2006: A longitudinal observation study. BMJ Open. 2013;3:e003169.
5. Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2011;(3):CD001886. doi: 10.1002/14651858.CD001886.pub4.
6. Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W. Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials. Thromb Res. 2009;123:687–696.
7. Poeran J, Rasul R, Suzuki S, et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: Retrospective analysis of effectiveness and safety. BMJ. 2014;349:g4829.
8. Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet. 2010;376:23–32.
9. Berntorp E, Follrud C, Lethagen S. No increased risk of venous thrombosis in women taking tranexamic acid. Thromb Haemost. 2001;86:714–715.
10. Nilsson IM. Local fibrinolysis as a mechanism for haemorrhage. Thromb Diath Haemorrh. 1975;34:623–633.
11. Bonnar J, Guillebaud J, Kasonde JM, Sheppard BL. Clinical applications of fibrinolytic inhibition in gynaecology. J Clin Pathol Suppl. 1980;14:55–59.
12. Gleeson NC, Buggy F, Sheppard BL, Bonnar J. The effect of tranexamic acid on measured menstrual loss and endometrial fibrinolytic enzymes in dysfunctional uterine bleeding. Acta Obstet Gynecol Scand. 1994;73:274–277.
13. Dockeray CJ, Sheppard BL, Daly L, Bonnar J. The fibrinolytic enzyme system in normal menstruation and excessive uterine bleeding and the effect of tranexamic acid. Eur J Obstet Gynecol Reprod Biol. 1987;24:309–318.
14. Marjoribanks J, Lethaby A, Farquhar C. Surgery versus medical therapy for heavy menstrual bleeding. Cochrane Database Syst Rev. 2006;(2):CD003855.
15. Al-Zirqi I, Vangen S, Forsen L, Stray-Pedersen B. Prevalence and risk factors of severe obstetric haemorrhage. BJOG. 2008;115:1265–1272.
16. Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost. 2003;29:125–130.
17. Novikova N, Hofmeyr GJ, Cluver C. Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database Syst Rev. 2015;6:Cd007872.
18. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. http://handbook.cochrane.org. Accessed October 21, 2016.
19. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Int J Surg. 2010;8:336–341.
20. Ramesh AC, Rajni S, Deka N. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: A randomized case controlled prospective study. Indian J Public Health Res Dev. 2015;6:12–15.
21. Mayur G, Purvi P, Ashoo G, Pankaj D. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: A randomized case controlled prospective study. J Obstet Gynecol India. 2007;57:227–230.
22. Abdel-Aleem H, Alhusaini TK, Abdel-Aleem MA, Menoufy M, Gulmezoglu AM. Effectiveness of tranexamic acid on blood loss in patients undergoing elective cesarean section: Randomized clinical trial. J Matern Fetal Neonatal Med. 2013;26:1705–1709.
23. Ahmed MR, Sayed Ahmed WA, Madny EH, Arafa AM, Said MM. Efficacy of tranexamic acid in decreasing blood loss in elective caesarean delivery. J Matern Fetal Neonatal Med. 2015;28:1014–1018.
24. Bhavana G, Mittal S. Evaluation of efficacy of prophylactic injection tranexamic acid in decreasing blood loss before and after caesarean section. BJOG. 2013;120:32.
25. Gai MY, Wu LF, Su QF, Tatsumoto K. Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: A multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol. 2004;112:154–157.
26. Goswami U, Sarangi S, Gupta S, Babbar S. Comparative evaluation of two doses of tranexamic acid used prophylactically in anemic parturients for lower segment cesarean section: A double-blind randomized case control prospective trial. Saudi J Anaesth. 2013;7:427–431.
27. Gungorduk K, Yildirim G, Asicioglu O, Gungorduk OC, Sudolmus S, Ark C. Efficacy of intravenous tranexamic acid in reducing blood loss after elective cesarean section: A prospective, randomized, double-blind, placebo-controlled study. Am J Perinatol. 2011;28:233–240.
28. Movafegh A, Eslamian L, Dorabadi A. Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. Int J Gynecol Obstet. 2011;115:224–226.
29. Sekhavat L, Tabatabaii A, Dalili M, Farajkhoda T, Tafti AD. Efficacy of tranexamic acid in reducing blood loss after cesarean section. J Matern Fetal Neonatal Med. 2009;22:72–75.
30. Shahid A, Khan A. Tranexamic acid in decreasing blood loss during and after caesarean section. J Coll Physicians Surg Pak. 2013;23:459–462.
31. Sharma R, Najam R, Misra MK. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section. Biomed Pharmacol J. 2011;4:231–235.
32. Taj N, Firdaus A, Akhtar N, Chaudhary MH, Bajwa SZ, Ullah E. Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. RMJ. 2014;39:311–313.
33. Tarabrin O, Galich S, Tkachenko R, Gulyaev A, Shcherbakov S, Gavrychenko D. Reduced blood loss during Caesarean section under the action of tranexamic acid. Eur J Anaesthesiol. 2012;29:97.
34. Xu J, Gao W, Ju Y. Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: A double-blind randomization trial. Arch Gynecol Obstet. 2013;287:463–468.
35. Bennasr L, Ben Marzouk S, Ajili S, et al. Effect of the addition of tranexamic acid on the prevention of bleeding during abdominal myomectomy: a randomized prospective study. Annales Francaises D Anesthesie et de Reanimation. 2014;33:75724.
36. Caglar GS, Tasci Y, Kayikcioglu F, Haberal A. Intravenous tranexamic acid use in myomectomy: A prospective randomized double-blind placebo controlled study. Eur J Obstet Gynecol Reprod Biol. 2008;137:227–231.
37. Mousa HA, Blum J, Abou El Senoun G, Shakur H, Alfirevic Z. Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2014;2:CD003249-CD.
38. van Ham MA, van Dongen PW, Mulder J. Maternal consequences of caesarean section. A retrospective study of intra-operative and postoperative maternal complications of caesarean section during a 10-year period. Eur J Obstet Gynecol Reprod Biol. 1997;74:1–6.
39. Ker K, Prieto-Merino D, Roberts I. Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. Br J Surg. 2013;100:1271–1279.
40. Dahlke JD, Mendez-Figueroa H, Rouse DJ, Berghella V, Baxter JK, Chauhan SP. Evidence-based surgery for cesarean delivery: An updated systematic review. Am J Obstet Gynecol. 2013;209:294–306.