Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors

Experimental Neurology

Volumn 295, Issue , 2017, Pages 66-76

  Huang, Ming ^a   Cheng, Gen ^a   Tan, Han ^a,d   Qin, Rui ^a   Zou, Yimin ^c   Wang, Yun ^a,b   Zhang, Ying ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Capsaicin; Cerebral ischemia; Excitotoxicity; MCAO; Neuroprotection; NMDA receptor

Indexed keywords

CALCIUM; CAPSAICIN; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN GLUN1; PROTEIN GLUN2B; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; EXCITATORY AMINO ACID; GPRIN1 PROTEIN, MOUSE; NERVE PROTEIN; NEUROPROTECTIVE AGENT; NR2B NMDA RECEPTOR; TRPV1 PROTEIN, MOUSE; VANILLOID RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CELL CULTURE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CALCIUM TRANSPORT; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG RESPONSE; EXCITOTOXICITY; GENE; IN VIVO STUDY; INTRACORTICAL DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR COORDINATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; TRPV1 GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; MOUSE; NERVE CELL; PATHOLOGY; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; CAPSAICIN; CELLS, CULTURED; DOWN-REGULATION; EXCITATORY AMINO ACIDS; GLUTAMIC ACID; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; REPERFUSION INJURY; TRPV CATION CHANNELS;

EID: 85020261024     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2017.05.001     Document Type: Article

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