A spike-specific whole-porcine antibody isolated from a porcine B cell that neutralizes both genogroup 1 and 2 PEDV strains

Veterinary Microbiology

Volumn 205, Issue , 2017, Pages 99-105

  Fu, Fang ^a   Li, Lin ^a   Shan, Lingling ^a   Yang, Beibei ^a   Shi, Hongyan ^a   Zhang, Jiaoer ^a   Wang, Hongfeng ^a   Feng, Li ^a   Liu, Pinghuang ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Memory B cell; Neutralizing antibody; Porcine epidemic diarrhea virus; Spike protein; Whole porcine monoclonal antibody

Indexed keywords

EPITOPE; IMMUNOGLOBULIN G; INACTIVATED VACCINE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PC10 ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS RNA; VIRUS VACCINE; VITRONECTIN; CORONAVIRUS SPIKE GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY ISOLATION; ANTIBODY RESPONSE; ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DRUG ISOLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; NONHUMAN; NUCLEOTIDE SEQUENCE; PORCINE EPIDEMIC DIARRHEA; PORCINE EPIDEMIC DIARRHEA VIRUS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VACCINATION; VERO CELL LINE; VIRION; VIRUS ATTACHMENT; VIRUS INHIBITION; VIRUS PARTICLE; VIRUS STRAIN; ANIMAL; CORONAVIRUS INFECTION; GENETICS; IMMUNOLOGY; PIG; SWINE DISEASE; VETERINARY; VIROLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; B-LYMPHOCYTES; CORONAVIRUS INFECTIONS; EPITOPES; GENOTYPE; PORCINE EPIDEMIC DIARRHEA VIRUS; SPIKE GLYCOPROTEIN, CORONAVIRUS; SWINE; SWINE DISEASES; VIRAL VACCINES;

EID: 85020188169     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2017.05.013     Document Type: Article

References (23)

1. Choudhury, B., Dastjerdi, A., Doyle, N., Frossard, J.P., Steinbach, F., From the field to the lab-an European view on the global spread of PEDV. Virus Res. 226 (2016), 40–49.
2. Chung, H.C., Lee, J.H., Nguyen, V.G., Huynh, T.M., Lee, G.E., Moon, H.J., Park, S.J., Kim, H.K., Park, B.K., New emergence pattern with variant porcine epidemic diarrhea viruses, South Korea, 2012–2015. Virus Res 226 (2016), 14–19.
3. Langel, S.N., Paim, F.C., Lager, K.M., Vlasova, A.N., Saif, L.J., Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): historical and current concepts. Virus Res. 226 (2016), 93–107.
4. Lee, D.H., Jeon, Y.S., Park, C.K., Kim, S., Lee, D.S., Lee, C., Immunoprophylactic effect of chicken egg yolk antibody (IgY) against a recombinant S1 domain of the porcine epidemic diarrhea virus spike protein in piglets. Arch. Virol. 160 (2015), 2197–2207.
5. Li, L., Fu, F., Xue, M., Chen, W., Liu, J., Shi, H., Chen, J., Bu, Z., Feng, L., Liu, P., IFN-lambda preferably inhibits PEDV infection of porcine intestinal epithelial cells compared with IFN-alpha. Antiviral Res. 140 (2017), 76–82.
6. Liao, H.X., Levesque, M.C., Nagel, A., Dixon, A., Zhang, R., Walter, E., Parks, R., Whitesides, J., Marshall, D.J., Hwang, K.K., Yang, Y., Chen, X., Gao, F., Munshaw, S., Kepler, T.B., Denny, T., Moody, M.A., Haynes, B.F., High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J. Virol. Methods 158 (2009), 171–179.
7. Liao, H.X., Bonsignori, M., Alam, S.M., Mclellan, J.S., Tomaras, G.D., Moody, M.A., Kozink, D.M., Hwang, K.K., Chen, X., Tsao, C.Y., Liu, P., Lu, X., Parks, R.J., Montefiori, D.C., Ferrari, G., Pollara, J., Rao, M., Peachman, K.K., Santra, S., Letvin, N.L., Karasavvas, N., Yang, Z.Y., Dai, K., Pancera, M., Gorman, J., Wiehe, K., Nicely, N.I., Rerks-Ngarm, S., Nitayaphan, S., Kaewkungwal, J., Pitisuttithum, P., Tartaglia, J., Sinangil, F., Kim, J.H., Michael, N.L., Kepler, T.B., Kwong, P.D., Mascola, J.R., Nabel, G.J., Pinter, A., Zolla-Pazner, S., Haynes, B.F., Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity 38 (2013), 176–186.
8. Lin, C.M., Saif, L.J., Marthaler, D., Wang, Q., Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains. Virus Res. 226 (2016), 20–39.
9. Liu, P., Williams, L.D., Shen, X., Bonsignori, M., Vandergrift, N.A., Overman, R.G., Moody, M.A., Liao, H.X., Stieh, D.J., Mccotter, K.L., French, A.L., Hope, T.J., Shattock, R., Haynes, B.F., Tomaras, G.D., Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. J. Virol. 88 (2014), 5165–5170.
10. Liu, C., Tang, J., Ma, Y., Liang, X., Yang, Y., Peng, G., Qi, Q., Jiang, S., Li, J., Du, L., Li, F., Receptor usage and cell entry of porcine epidemic diarrhea coronavirus. J. Virol. 89 (2015), 6121–6125.
11. Liu, C., Ma, Y., Yang, Y., Zheng, Y., Shang, J., Zhou, Y., Jiang, S., Du, L., Li, J., Li, F., Cell entry of porcine epidemic diarrhea coronavirus is activated by lysosomal proteases. J. Biol. Chem. 291 (2016), 24779–24786.
12. Madson, D.M., Magstadt, D.R., Arruda, P.H., Hoang, H., Sun, D., Bower, L.P., Bhandari, M., Burrough, E.R., Gauger, P.C., Pillatzki, A.E., Stevenson, G.W., Wilberts, B.L., Brodie, J., Harmon, K.M., Wang, C., Main, R.G., Zhang, J., Yoon, K.J., Pathogenesis of porcine epidemic diarrhea virus isolate (US/Iowa/18984/2013) in 3-week-old weaned pigs. Vet. Microbiol. 174 (2014), 60–68.
13. Park, J.E., Cruz, D.J., Shin, H.J., Receptor-bound porcine epidemic diarrhea virus spike protein cleaved by trypsin induces membrane fusion. Arch. Virol. 156 (2011), 1749–1756.
14. Park, J.E., Cruz, D.J., Shin, H.J., Clathrin- and serine proteases-dependent uptake of porcine epidemic diarrhea virus into Vero cells. Virus Res. 191 (2014), 21–29.
15. Sayers, C.L., Elliott, G., HSV1 enters human keratinocytes by a nectin-1-dependent, rapid plasma membrane fusion pathway that functions at low temperature. J. Virol., 2016.
16. Smith, K., Garman, L., Wrammert, J., Zheng, N.Y., Capra, J.D., Ahmed, R., Wilson, P.C., Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nat. Protoc. 4 (2009), 372–384.
17. Song, D., Park, B., Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines. Virus Genes 44 (2012), 167–175.
18. Song, Q., Stone, S., Drebes, D., Greiner, L.L., Dvorak, C.M., Murtaugh, M.P., Characterization of anti-porcine epidemic diarrhea virus neutralizing activity in mammary secretions. Virus Res., 2016.
19. Sun, D., Wang, X., Wei, S., Chen, J., Feng, L., Epidemiology and vaccine of porcine epidemic diarrhea virus in China: a mini-review. J. Vet. Med. Sci. 78 (2016), 355–363.
20. Tomaras, G.D., Yates, N.L., Liu, P., Qin, L., Fouda, G.G., Chavez, L.L., Decamp, A.C., Parks, R.J., Ashley, V.C., Lucas, J.T., Cohen, M., Eron, J., Hicks, C.B., Liao, H.X., Self, S.G., Landucci, G., Forthal, D.N., Weinhold, K.J., Keele, B.F., Hahn, B.H., Greenberg, M.L., Morris, L., Karim, S.S., Blattner, W.A., Montefiori, D.C., Shaw, G.M., Perelson, A.S., Haynes, B.F., Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. J. Virol. 82 (2008), 12449–12463.
21. Wang, Y., Li, J.R., Sun, M.X., Ni, B., Huan, C., Huang, L., Li, C., Fan, H.J., Ren, X.F., Mao, X., Triggering unfolded protein response by 2-deoxy-d-glucose inhibits porcine epidemic diarrhea virus propagation. Antiviral Res. 106 (2014), 33–41.
22. Wang, D., Fang, L., Xiao, S., Porcine epidemic diarrhea in China. Virus Res., 2016.
23. Wang, X., Chen, J., Shi, D., Shi, H., Zhang, X., Yuan, J., Jiang, S., Feng, L., Immunogenicity and antigenic relationships among spike proteins of porcine epidemic diarrhea virus subtypes G1 and G2. Arch. Virol. 161 (2016), 537–547.