Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets

Multiple Sclerosis

Volumn 23, Issue 7, 2017, Pages 1025-1030

  Gross, Catharina C ^a   Schulte Mecklenbeck, Andreas ^a   Hanning, Uta ^a   Posevitz Fejfár, Anita ^a   Korsukewitz, Catharina ^a   Schwab, Nicholas ^a   Meuth, Sven G ^a   Wiendl, Heinz ^a   Klotz, Luisa ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

innate lymphoid cell; lesion distribution; lymphoid tissue inducer; Multiple sclerosis; TH1; TH17

Indexed keywords

CD123 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45RO ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 17; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; STEM CELL FACTOR RECEPTOR; CYTOKINE; INTERLEUKIN 22;

ADULT; ARTICLE; CELL SUBPOPULATION; CEREBROSPINAL FLUID ANALYSIS; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOCYTE FUNCTION; LYMPHOID CELL; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; TH1 CELL; TH17 CELL; AGED; BRAIN DAMAGE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; LYMPHOID TISSUE; PERIPHERAL LYMPHOCYTE; SPINAL CORD LESION; T LYMPHOCYTE SUBPOPULATION;

EID: 85020175376     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458516662726     Document Type: Article

References (12)

1. Stromnes IM, Cerretti LM, Liggitt D, et al. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat Med 2008; 14 (3): 337-342.
2. Rothhammer V, Heink S, Petermann F, et al. Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE. J Exp Med 2011; 208 (12): 2465-2476.
3. Domingues HS, Mues M, Lassmann H, et al. Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS ONE 2010; 5 (11): e15531.
4. Schneider-Hohendorf T, Rossaint J, Mohan H, et al. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med 2014; 211 (9): 1833-1846.
5. Bernink JH, Peters CP, Munneke M, et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol 2013; 14 (3): 221-229.
6. Hoorweg K, Peters CP, Cornelissen F, et al. Functional differences between human NKp44(-) and NKp44(+) RORC(+) innate lymphoid cells. Front Immunol 2012; 3: 72.
7. Walker JA, Barlow JL, McKenzie AN,. Innate lymphoid cells-How did we miss them? Nat Rev Immunol 2013; 13 (2): 75-87.
8. Bettelli E, Baeten D, Jager A, et al. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest 2006; 116 (9): 2393-2402.
9. Krishnamoorthy G, Lassmann H, Wekerle H, et al. Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest 2006; 116 (9): 2385-2392.
10. Quintana A, Müller M, Frausto RF, et al. Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis. J Immunol 2009; 183 (3): 2079-2088.
11. Lee LF, Axtell R, Tu GH, et al. IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-beta in multiple sclerosis. Sci Transl Med 2011; 3 (93): 93ra68.
12. Waisman A, Hauptmann J, Regen T,. The role of IL-17 in CNS diseases. Acta Neuropathol 2015; 129 (5): 625-637.