OXA-48-like carbapenemases in the UK: An analysis of isolates and cases from 2007 to 2014

Journal of Antimicrobial Chemotherapy

Volumn 72, Issue 5, 2017, Pages 1340-1349

  Findlay, Jacqueline ^a   Hopkins, Katie L ^a   Loy, Richard ^a   Doumith, Michel ^a   Meunier, Danièle ^a   Hill, Robert ^a   Pike, Rachel ^a   Mustafa, Nazim ^a   Livermore, David M ^a,b   Woodford, Neil ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BETA LACTAMASE CTX M; BETA LACTAMASE TEM 1; BLA OXA 181 CARBAPENEMASE; BLA OXA 232 CARBAPENEMASE; BLA OXA 244 CARBAPENEMASE; BLA OXA 245 CARBAPENEMASE; BLA OXA 484 CARBAPENEMASE; CARBAPENEMASE; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; ERTAPENEM; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; MEROPENEM; OXA 48 LIKE CARBAPENEMASE; PIPERACILLIN PLUS TAZOBACTAM; TIGECYCLINE; TOBRAMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE; OXACILLINASE;

AGAR DILUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BLOOD CULTURE; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; CITROBACTER; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE; ENTEROBACTER HORMAECHEI; ESCHERICHIA COLI; GENE MAPPING; HUMAN; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RAOUTELLA ORNITHINOLYTICA; SERRATIA MARCESCENS; UNITED KINGDOM; BACTERIAL GENOME; DNA SEQUENCE; DRUG EFFECTS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTION; ENZYMOLOGY; GENETICS; HIGH THROUGHPUT SEQUENCING; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MULTILOCUS SEQUENCE TYPING; PLASMID;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; GENOME, BACTERIAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MULTILOCUS SEQUENCE TYPING; PLASMIDS; SEQUENCE ANALYSIS, DNA; UNITED KINGDOM;

EID: 85020089644     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkx012     Document Type: Article

References (32)

1. Poirel L, Heritier C, Tolun V et al. Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother 2004; 48: 15-22
2. Albiger B, Glasner C, Struelens MJ et al. Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015. Euro Surveill 2015; 20: pii"30062
3. Mathers AJ, Hazen KC, Carroll J et al. First clinical cases of OXA-48-producing carbapenem-resistant Klebsiella pneumoniae in the United States: the 'menace' arrives in the newworld. JClinMicrobiol 2013; 51: 680-3
4. Nordmann P, Naas T, Poirel L. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 2011; 17: 1791-8
5. Poirel L, Potron A, Nordmann P. OXA-48-like carbapenemases: the phantommenace. J Antimicrob Chemother. 2012; 67: 1597-606
6. Antunes NT, Lamoureaux TL, Toth M et al. Class D b-lactamases: are they all carbapenemases? Antimicrob Agents Chemother 2014; 58: 2119-25
7. Dortet L, Oueslati S, Jeannot K et al. Genetic and biochemical characterization of OXA-405, an OXA-48-type extended-spectrum b-lactamase without significant carbapenemase activity. Antimicrob Agents Chemother 2015; 59: 3823-8
8. Gomez S, Pasteran F, Faccone D et al. Intrapatient emergence of OXA-247: a novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae. ClinMicrobiol Infect 2013; 19: E233-5
9. Poirel L, Castanheira M, Carrer A et al. OXA-163, an OXA-48-related class D b-lactamase with extended activity toward expanded-spectrum cephalosporins. Antimicrob Agents Chemother 2011; 55: 2546-51
10. Dimou V, Dhanji H, Pike R et al. Characterization of Enterobacteriaceae producing OXA-48-like carbapenemases in the UK. J Antimicrob Chemother 2012; 67: 1660-5
11. Doi Y, O'Hara JA, Lando JF et al. Co-production of NDM-1 and OXA-232 by Klebsiella pneumoniae. Emerg Infect Dis 2014; 20: 163-5
12. Castanheira M, Deshpande LM, Mathai D et al. Early dissemination of NDM-1-and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007. Antimicrob Agents Chemother 2011; 55: 1274-8
13. Potron A, Kalpoe J, Poirel L et al. European dissemination of a single OXA-48-producing Klebsiella pneumoniae clone. Clin Microbiol Infect 2011; 17: E24-6
14. Poirel L, Ros A, Carrer A et al. Cross-border transmission of OXA-48-producing Enterobacter cloacae from Morocco to France. J Antimicrob Chemother 2011; 66: 1181-2
15. Poirel L, Bonnin RA, Nordmann P. Genetic features of the widespread plasmid coding for the carbapenemase OXA-48. Antimicrob Agents Chemother 2012; 56: 559-62
16. Andrews JM. Determination of minimum inhibitory concentrations. J Antimicrob Chemother 2001; 48 Suppl 1: 5-16
17. EUCAST. Clinical Breakpoint Table, Version 6. 0. http://www. eucast. org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_6. 0_Br eakpoint_table. pdf
18. Woodford N, Warner M, Pike R et al. Evaluation of a commercial microarray to detect carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother 2011; 66: 2887-8
19. Ellington MJ, Kistler J, Livermore DM et al. Multiplex PCR for rapid detection of genes encoding acquired metallo-β-lactamases. J Antimicrob Chemother 2007; 59: 321-2
20. Doumith M, Day M, Ciesielczuk H et al. Rapid identification of major Escherichia coli sequence types causing urinary tract and bloodstream infections. J ClinMicrobiol 2015; 53: 160-6
21. Meunier D, Doumith M, Findlay J et al. Carbapenem resistance mediated by blaOXA-181 in Pseudomonas aeruginosa. J Antimicrob Chemother 2016; 71: 2056-7
22. EUCAST. EUCAST Guidelines for Detection of Resistance Mechanisms and Specific Resistances of Clinical and/or Epidemiological Importance, Version 1. 0. http://www. eucast. org/fileadmin/src/media/PDFs/EUCAST_ files/Resistance:mechanisms/EUCAST_detection_of_resistance:mecha nisms_v1. 0_20131211. pdf
23. Livermore DM, Mushtaq S, Warner M et al. Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemaseproducing Enterobacteriaceae. Antimicrob Agents Chemother 2011; 55: 390-4
24. Noskin GA. Tigecycline: a newglycylcycline for treatment of serious infections. Clin Infect Dis 2005; 41 Suppl 5: S303-14
25. Spapen H, Jacobs R, Van Gorp V et al. Renal and neurological side effects of colistin in critically ill patients. Ann Intensive Care 2011; 1: 14
26. Carrer A, Poirel L, Yilmaz M et al. Spread of OXA-48-encoding plasmid in Turkey and beyond. Antimicrob Agents Chemother 2010; 54: 1369-73
27. Carrer A, Poirel L, Eraksoy H et al. Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Antimicrob Agents Chemother 2008; 52: 2950-4
28. Potron A, Rondinaud E, Poirel L et al. Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D b-lactamase from Enterobacteriaceae. Int J Antimicrob Agents 2013; 41: 325-9
29. Potron A, Nordmann P, Lafeuille E et al. Characterization of OXA-181, a carbapenem-hydrolyzing class D b-lactamase from Klebsiella pneumoniae. Antimicrob Agents Chemother 2011; 55: 4896-9
30. Liu Y, Feng Y, Wu Wet al. First report of OXA-181-producing Escherichia coli in China and characterization of the isolate using whole-genome sequencing. Antimicrob Agents Chemother 2015; 59: 5022-5
31. Pitout JD. Extraintestinal pathogenic Escherichia coli: a combination of virulencewith antibiotic resistance. FrontMicrobiol 2012; 3: 9
32. Turton JF, Doumith M, Hopkins KL et al. Clonal expansion of Escherichia coli ST38 carrying chromosomally-integrated OXA-48 carbapenemase gene. JMedMicrobiol 2016; 65: 538-46