Genetic and biochemical characterization of OXA-405, an OXA-48-type extended-spectrum β-lactamase without significant carbapenemase activity

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 7, 2015, Pages 3823-3828

  Dortet, Laurent ^a,b,c,d   Oueslati, Saoussen ^a   Jeannot, Katy ^b,e   Tandé, Didier ^f   Naas, Thierry ^a,b,c,d   Nordmann, Patrice ^a,b,g,h  

^a Associated French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae   (France)

^b Associated National Reference Center for Antibiotic Resistance   (France)

^c University of Paris South   (France)

^d BICÊTRE HOSPITAL   (France)

^e UNIVERSITY HOSPITAL OF BESANÇON   (France)

^f Brest Teaching Hospitals   (France)

^g UNIVERSITY OF FRIBOURG   (Switzerland)

^h Hopital Cantonal de Fribourg   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM DERIVATIVE; CARBAPENEMASE; CEPHALOSPORIN DERIVATIVE; CLAVULANIC ACID; EXTENDED SPECTRUM BETA LACTAMASE; OXA 405 PROTEIN; PENICILLIN DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL DNA; BACTERIAL PROTEIN; BETA LACTAMASE; BETA-LACTAMASE OXA-405, SERRATIA MARCESCENS;

ANTIBIOTIC RESISTANCE; ARTICLE; AUTOMATION; BACTERIAL GENOME; BACTERIUM ISOLATE; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; GENE IDENTIFICATION; GENE LOCATION; GENE SEQUENCE; GENETIC ANALYSIS; NONHUMAN; PLASMID; PLASTICITY; POLYMERASE CHAIN REACTION SYSTEM; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SERRATIA MARCESCENS; ADULT; CHEMISTRY; DNA SEQUENCE; DRUG EFFECTS; FEMALE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR GENETICS; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; SERRATIA INFECTIONS;

ADULT; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; BETA-LACTAMASES; CARBAPENEMS; CEPHALOSPORINS; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; SEQUENCE ANALYSIS, DNA; SERRATIA INFECTIONS; SERRATIA MARCESCENS;

EID: 84931282004     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05058-14     Document Type: Article

References (24)

1. Poirel L, Naas T, Nordmann P. 2010. Diversity, epidemiology, and genetics of class D β-lactamases. Antimicrob Agents Chemother 54:24-38. http://dx.doi.org/10.1128/AAC.01512-08.
2. Higgins PG, Poirel L, Lehmann M, Nordmann P, Seifert H. 2009. OXA-143, a novel carbapenem-hydrolyzing class D β-lactamase in Acinetobacter baumannii. Antimicrob Agents Chemother 53:5035-5038. http://dx.doi.org/10.1128/AAC.00856-09.
3. Poirel L, Nordmann P. 2006. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin Microbiol Infect 12: 826-836. http://dx.doi.org/10.1111/j.1469-0691.2006.01456.x.
4. Poirel L, Potron A, Nordmann P. 2012. OXA-48-like carbapenemases: the phantom menace. J Antimicrob Chemother 67:1597-1606. http://dx.doi.org/10.1093/jac/dks121.
5. Poirel L, Heritier C, Tolun V, Nordmann P. 2004. Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother 48:15-22. http://dx.doi.org/10.1128/AAC.48.1.15-22.2004.
6. Kasap M, Torol S, Kolayli F, Dundar D, Vahaboglu H. 2013. OXA-162, a novel variant of OXA-48, displays extended hydrolytic activity towards imipenem, meropenem and doripenem. J Enzyme Inhib Med Chem 28: 990-996. http://dx.doi.org/10.3109/14756366.2012.702343.
7. Abdelaziz MO, Bonura C, Aleo A, El-Domany RA, Fasciana T, Mammina C. 2012. OXA-163-producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010. J Clin Microbiol 50:2489-2491. http://dx.doi.org/10.1128/JCM.06710-11.
8. Poirel L, Castanheira M, Carrer A, Rodriguez CP, Jones RN, Smayevsky J, Nordmann P. 2011. OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins. Antimicrob Agents Chemother 55:2546-2551. http://dx.doi.org/10.1128/AAC.00022-11.
9. Potron A, Nordmann P, Lafeuille E, Al Maskari Z, Al Rashdi F, Poirel L. 2011. Characterization of OXA-181, a carbapenem-hydrolyzing class D β-lactamase from Klebsiella pneumoniae. Antimicrob Agents Chemother 55:4896-4899. http://dx.doi.org/10.1128/AAC.00481-11.
10. Potron A, Nordmann P, Poirel L. 2013. Characterization of OXA-204, a carbapenem-hydrolyzing class D β-lactamase from Klebsiella pneumoniae. Antimicrob Agents Chemother 57:633-636. http://dx.doi.org/10.1128/AAC.01034-12.
11. Potron A, Rondinaud E, Poirel L, Belmonte O, Boyer S, Camiade S, Nordmann P. 2013. Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Enterobacteriaceae. Int J Antimicrob Agents 41:325-329. http://dx.doi.org/10.1016/j.ijantimicag.2012.11.007.
12. Oteo J, Hernandez JM, Espasa M, Fleites A, Saez D, Bautista V, Perez-Vazquez M, Fernandez-Garcia MD, Delgado-Iribarren A, Sanchez-Romero I, Garcia-Picazo L, Miguel MD, Solis S, Aznar E, Trujillo G, Mediavilla C, Fontanals D, Rojo S, Vindel A, Campos J. 2013. Emergence of OXA-48-producing Klebsiella pneumoniae and the novel carbapenemases OXA-244 and OXA-245 in Spain. J Antimicrob Chemother 68:317-321. http://dx.doi.org/10.1093/jac/dks383.
13. Gomez S, Pasteran F, Faccone D, Bettiol M, Veliz O, De Belder D, Rapoport M, Gatti B, Petroni A, Corso A. 2013. Intrapatient emergence of OXA-247: a novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae. Clin Microbiol Infect 19:E233-E235. http://dx.doi.org/10.1111/1469-0691.12142.
14. Sampaio JL, Ribeiro VB, Campos JC, Rozales FP, Magagnin CM, Falci DR, da Silva RC, Dalarosa MG, Luz DI, Vieira FJ, Antochevis LC, Barth AL, Zavascki AP. 2014. Detection of OXA-370, an OXA-48-related class D β-lactamase, in Enterobacter hormaechei from Brazil. Antimicrob Agents Chemother 58:3566-3567. http://dx.doi.org/10.1128/AAC.02510-13.
15. Nordmann P, Poirel L, Dortet L. 2012. Rapid detection of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 18:1503-1507. http://dx.doi.org/10.3201/eid1809.120355.
16. Bernabeu S, Poirel L, Nordmann P. 2012. Spectrophotometry-based detection of carbapenemase producers among Enterobacteriaceae. Diagn Microbiol Infect Dis 74:88-90. http://dx.doi.org/10.1016/j.diagmicrobio.2012.05.021.
17. Dortet L, Brechard L, Poirel L, Nordmann P. 2014. Impact of the isolation medium for detection of carbapenemase-producing Enterobacteriaceae using an updated version of the Carba NP test. J Med Microbiol 63:772-776. http://dx.doi.org/10.1099/jmm.0.071340-0.
18. Kieser T. 1984. Factors affecting the isolation of CCC DNA from Streptomyces lividans and Escherichia coli. Plasmid 12:19-36. http://dx.doi.org/10.1016/0147-619X(84)90063-5.
19. Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, Threlfall EJ. 2005. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 63:219-228. http://dx.doi.org/10.1016/j.mimet.2005.03.018.
20. Poirel L, Bonnin RA, Nordmann P. 2012. Genetic features of the widespread plasmid coding for the carbapenemase OXA-48. Antimicrob Agents Chemother 56:559-562. http://dx.doi.org/10.1128/AAC.05289-11.
21. Docquier JD, Calderone V, De Luca F, Benvenuti M, Giuliani F, Bellucci L, Tafi A, Nordmann P, Botta M, Rossolini GM, Mangani S. 2009. Crystal structure of the OXA-48 β-lactamase reveals mechanistic diversity among class D carbapenemases. Chem Biol 16:540-547. http://dx.doi.org/10.1016/j.chembiol.2009.04.010.
22. De Luca F, Benvenuti M, Carboni F, Pozzi C, Rossolini GM, Mangani S, Docquier JD. 2011. Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design. Proc Natl Acad Sci U S A 108:18424-18429. http://dx.doi.org/10.1073/pnas.1110530108.
23. Mitchell JM, Clasman JR, June CM, Kaitany KC, LaFleur JR, Taracila MA, Klinger NV, Bonomo RA, Wymore T, Szarecka A, Powers RA, Leonard DA. 2015. Structural basis of activity against aztreonam and extended-spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii. Biochemistry 54: 1976-1987. http://dx.doi.org/10.1021/bi501547k.
24. Poirel L, Weldhagen GF, Naas T, De Champs C, Dove MG, Nordmann P. 2001. GES-2, a class A β-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem. Antimicrob Agents Chemother 45: 2598-2603. http://dx.doi.org/10.1128/AAC.45.9.2598-2603.2001.