Working hard for oneself or others: Effects of oxytocin on reward motivation in social anxiety disorder

Biological Psychology

Volumn 127, Issue , 2017, Pages 157-162

  Fang, Angela ^a   Treadway, Michael T ^b   Hofmann, Stefan G ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b EMORY UNIVERSITY   (United States)

^c BOSTON UNIVERSITY   (United States)

Author keywords

Motivation; Other; Oxytocin; Reward; Self

Indexed keywords

OXYTOCIN; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EMOTIONAL ATTACHMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTIVATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REWARD; SOCIAL BEHAVIOR; SOCIAL INTERACTION; SOCIAL PHOBIA; YOUNG ADULT; DRUG EFFECTS; OBJECT RELATION; PSYCHOLOGY; TREATMENT OUTCOME;

ADULT; HUMANS; MALE; MOTIVATION; OBJECT ATTACHMENT; OXYTOCIN; PHOBIA, SOCIAL; REWARD; SOCIAL BEHAVIOR; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85020056201     PISSN: 03010511     EISSN: 18736246     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2017.05.015     Document Type: Article

References (44)

1. Bartz, J.A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N.N., Kolevzon, A., Ochsner, K.N., Oxytocin selectively improves empathic accuracy. Psychological Science 21 (2010), 1426–1428.
2. Bartz, J.A., Zaki, J., Bolger, N., Ochsner, K.N., Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Sciences 15 (2011), 301–309.
3. Brennan, K.A., Clark, C.L., Shaver, P.R., Self-report measurement of adult attachment: An integrative overview. Simpson, J.A., Rholes, W.S., (eds.) Attachment theory and close relationships, 1998, Guilford Press, New York, 46–76.
4. Clark, D.B., Feske, U., Masia, C.L., Spaulding, S.A., Brown, C., Mammen, O., Shear, M.K., Systematic assessment of social phobia in clinical practice. Depression and Anxiety 6 (1997), 47–61.
5. Colonello, V., Chen, F.S., Panksepp, J., Heinrichs, M., Oxytocin sharpens self-other perceptual boundary. Psychoneuroendocrinology 38 (2013), 2996–3002.
6. Colonnello, V., Heinrichs, M., Intranasal oxytocin enhances positive self-attribution in healthy men. Journal of Psychosomatic Research 77 (2014), 415–419.
7. De Dreu, C.K.W., Greer, L.L., Handgraaf, M.J.J., Shalvi, S., Van Kleef, G.A., Baas, M., Feith, S.W.W., The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans. Science 328 (2010), 1408–1411.
8. De Waal, F.B.M., Putting the altruism back into altruism: The evolution of empathy. Annual Review of Psychology 59 (2008), 279–300.
9. DiNardo, P.A., Brown, T.A., Barlow, D.H., Anxiety disorders interview schedule for DSM-IV: Client interview schedule. 1994, Oxford University Press, New York.
10. Dumais, K.M., Veenema, A.H., Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior. Frontiers in Neuroendocrinology 40 (2015), 1–23.
11. Eisenberg, N., Miller, P.A., The relation of empathy to prosocial and related behaviors. Psychological Bulletin 101 (1987), 91–119.
12. Fang, A., Hoge, E.A., Heinrichs, M., Hofmann, S.G., Attachment style moderates the effects of oxytocin on social behaviors and cognitions during social rejection: Applying a research domain criteria framework to social anxiety. Clinical Psychological Science 2 (2014), 740–747.
13. Guastella, A.J., Einfeld, S.L., Gray, K.M., Rinehart, N.J., Tonge, B.J., Lambert, T.J., Hickie, I.B., A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology 34 (2009), 917–923.
14. Heinrichs, M., Baumgartner, T., Kirschbaum, C., Ehlert, U., Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry 54 (2003), 1389–1398.
15. Hofmann, S.G., Smits, J.A., Cognitive-behavioral therapy for adult anxiety disorders: A meta-analysis of randomized placebo-controlled trials. Journal of Clinical Psychiatry 69 (2008), 621–632.
16. Hofmann, S.G., Cognitive factors that maintain social anxiety disorder: A comprehensive model and its treatment implications. Cognitive Behaviour Therapy 36 (2007), 193–209.
17. Hurlemann, R., Scheele, D., Dissecting the role of oxytocin in the formation and loss of social relationships. Biological Psychiatry 79 (2016), 185–193.
18. Hurlemann, R., Patin, A., Onur, O.A., Cohen, M.X., Baumgartner, T., Metzler, S., Kendrick, K.M., Oxytocin enhances amygdala-dependent:socially reinforced learning and emotional empathy in humans. Journal of Neuroscience 30 (2010), 4999–5007.
19. Ingram, R.E., Self-focused attention in clinical disorders: Review and a conceptual model. Psychological Bulletin 107:2 (1990), 156–176.
20. Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D.S., Quinn, K., Wang, P., Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. American Journal of Psychiatry 167 (2010), 748–751.
21. Kemp, A.H., Guastella, A.J., The role of oxytocin in human affect: A novel hypothesis. Current Directions in Psychological Science 20 (2011), 222–231.
22. Kosfeld, M., Heinrichs, M., Zak, P.J., Fischbacher, U., Fehr, E., Oxytocin increases trust in humans. Nature 435 (2005), 673–676.
23. Labuschagne, I., Phan, K.L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Nathan, P.J., Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology 35 (2010), 2403–2413.
24. Liebowitz, M.R., Social phobia. Modern Problems in Pharmacopsychiatry 22 (1987), 141–173.
25. Manning, J., Reynolds, G., Saygin, Z.M., Hofmann, S.G., Pollack, M., Gabrieli, J.D.E., Whitfield-Gabrieli, S., Altered resting-state functional connectivity of the frontal-striatal reward system in social anxiety disorder. PLoS ONE, 10, 2015, e0125286.
26. Mattick, R.P., Clarke, J.C., Development and validation of measures of social phobia scrutiny fear and social interaction anxiety. Behaviour Research and Therapy 36 (1998), 455–470.
27. Notzon, S., Domschke, K., Holitschke, K., Ziegler, C., Arolt, V., Pauli, P., Zwanzger, P., Attachment style and oxytocin receptor gene variation interact in influencing social anxiety. World Journal of Biological Psychiatry 17 (2016), 76–83.
28. Olff, M., Frijling, J.L., Kubzansky, L.D., Bradley, B., Ellenbogen, M.A., Cardoso, C., van Zuiden, M., The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology 38 (2013), 1863–1894.
29. Posner, M.I., Orienting of attention. Quarterly Journal of Experimental Psychology 32 (1980), 3–25.
30. Quattrocki, E., Friston, K., Autism, oxytocin and interoception. Neuroscience and Biobehavioral Reviews 47 (2014), 410–430.
31. Quintana, D.S., Woolley, J.D., Intranasal oxytocin mechanisms can be better understood, but its effects on social cognition and behavior are not to be sniffed at. Biological Psychiatry 79 (2015), e49–50.
32. Safren, S.A., Heimberg, R.G., Horner, K.J., Juster, H.R., Schneier, F.R., Liebowitz, M.R., Factor structure of social fears: The liebowitz social anxiety scale. Journal of Anxiety Disorders 13 (1999), 253–270.
33. Scheele, D., Kendrick, K.M., Khouri, C., Kretzer, E., Schläpfer, T.E., Stoffel-Wagner, B., Hurlemann, R., An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits. Neuropsychopharmacology 39 (2014), 2078–2085.
34. Shahrestani, S., Kemp, A.H., Guastella, A.J., The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: A meta-analysis. Neuropsychopharmacology 38 (2013), 1929–1936.
35. Shamay-Tsoory, S.G., Abu-Akel, A., The social salience hypothesis of oxytocin. Biological Psychiatry 79 (2016), 194–202.
36. Shamay-Tsoory, S.G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., Levkovitz, Y., Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biological Psychiatry 66 (2009), 864–870.
37. Shamay-Tsoory, S.G., Oxytocin, social salience, and social approach. Biological Psychiatry, 67, 2010, e35.
38. Spurr, J.M., Stopa, L., Self-focused attention in social phobia and social anxiety. Clinical Psychology Review 22 (2002), 947–975.
39. Sripada, C., Angstadt, M., Liberzon, I., McCabe, K., Phan, K.L., Aberrant reward center response to partner reputation during a social exchange game in generalized social phobia. Depression and Anxiety 30 (2013), 353–361.
40. Striepens, N., Kendrick, K.M., Hanking, V., Landgraf, R., Wüllner, U., Maier, W., Hurlemann, R., Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans. Scientific Reports, 3, 2013, 3440.
41. Treadway, M.T., Buckholtz, J.W., Schwartzman, A.N., Lambert, W.E., Zald, D.H., Worth the ‘EEfRT’? The effort expenditure for rewards task as an objective measure of motivation and anhedonia. PLoS ONE 4 (2009), 1–9.
42. Williams, K.D., Cheung, C.K.T., Choi, W., Cyberostracism: Effects of being ignored over the Internet. Journal of Personality and Social Psychology 79 (2000), 748–762.
43. Zak, P.J., Stanton, A.A., Ahmadi, S., Oxytocin increases generosity in humans. PloS One, 2, 2007, e1128.
44. Zhao, W., Yao, S., Li, Q., Geng, Y., Ma, X., Luo, L., Kendrick, K.M., Oxytocin blurs the self-other distinction during trait judgments and reduces medial prefrontal cortex responses. Human Brain Mapping 37 (2016), 2512–2527.