Attachment style moderates the effects of oxytocin on social behaviors and cognitions during social rejection: Applying a research domain criteria framework to social anxiety

Clinical Psychological Science

Volumn 2, Issue 6, 2014, Pages 740-747

  Fang, Angela ^a,b,c   Hoge, Elizabeth A ^b,c   Heinrichs, Markus ^d   Hofmann, Stefan G ^a  

^a BOSTON UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Individual differences; Oxytocin; RDoC; Social anxiety disorder; Social rejection

Indexed keywords

EID: 84927710858     PISSN: 21677026     EISSN: 21677034     Source Type: Journal    
DOI: 10.1177/2167702614527948     Document Type: Article

References (39)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2. Bartz, J.A., Zaki, J., Bolger, N., & Ochsner, K.N. (2011). Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Sciences, 15, 301-309. doi:10.1016/j.tics.2011.05.002.
3. Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008). Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron, 58, 639-650. doi:10.1016/j.neuron.2008.04.009
4. Boyce, P., & Parker, G. (1989). Development of a scale to measure interpersonal sensitivity. Australian and New Zealand Journal of Psychiatry, 23, 341-351. doi:10.3109/00048678909068294
5. Brennan, K. A., Clark, C. L., & Shaver, P. R. (1998). Self-report measurement of adult attachment: An integrative overview. In J. A. Simpson & W. S. Rholes (Eds.), Attachment theory and close relationships (pp. 46-76). New York: Guilford Press.
6. Buchheim, A., Heinrichs, M., George, C., Pokorny, D., Koops, E., Henningsen, P.,…Gündel, H. (2009). Oxytocin enhances the experience of attachment security. Psychoneuroendocrinology, 34, 1417-1422. doi:10.1016/j.psyneuen.2009.04.002
7. Congdon, E., Lesch, K. P., & Canli, T. (2008). Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: Implications for impulsivity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 27-32. doi:10.1002/ajmg.b.30557
8. Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., … Martini, C. (2009). Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 34, 1506-1514. doi:10.1016/j.psyneuen.2009.05.006
9. Davis, M. C., Lee, J., Horan, W. P., Clarke, A. D., McGee, M. R., Green, M. F., & Marder, S. R. (2013). Effects of single dose intranasal oxytocin on social cognition in schizophrenia. Schizophrenia Research, 147, 393-397. doi:10.1016/j.schres.2013.04.023
10. DiNardo, P. A., Brown, T. A., & Barlow, D. H. (1994). Anxiety Disorders Interview Schedule for DSM-IV: Client Interview Schedule. New York, NY: Oxford University Press.
11. Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007). Oxytocin improves “mind-reading” in humans. Biological Psychiatry, 61, 731-733. doi:10.1016/j.biopsych.2006.07.015
12. Ellenbogen, M. A., Linnen, A., Grumet, R., Cardoso, C., & Joober, R. (2012). The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces. Psychophysiology, 49, 128-137. doi:10.1111/j.1469-8986.2011.01278.x
13. Essex, M. J., Klein, M. H., Slattery, M. J., Goldsmith, H. H., & Kalin, N. H. (2010). Early risk factors and developmental pathways to chronic high inhibition and social anxiety disorder in adolescence. American Journal of Psychiatry, 167, 40-46. doi:10.1176/appi.ajp.2009.07010051
14. Evans, S. L., Monte, O. D., Noble, P., & Averbeck, B. B. (2013). Intranasal oxytocin effects on social cognition: A critique. Brain Research. Advance online publication. doi:10.1016/j.brainres.2013.11.008
15. Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry, 67, 692-694. doi:10.1016/j.biopsych.2009.09.020
16. Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009). A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology, 34, 917-923. doi:10.1016/j.psyneuen.2009.01.005
17. Harb, G. C., Heimberg, R. G., Fresco, D. M., Schneier, F. R., & Liebowitz, M. R. (2002). The psychometric properties of the Interpersonal Sensitivity Measure in social anxiety disorder. Behaviour Research and Therapy, 40, 961-980. doi:10.1016/S0005-7967(01)00125-5
18. Heinrichs, M., Chen, F. S., & Domes, G. (2012). Oxytocin. In S. G. Hofmann (Ed.), Psychobiological approaches for anxiety disorders: Treatment combination strategies (pp. 123-143). Oxford: Wiley-Blackwell. doi:10.1002/9781119945901.ch8
19. Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 15, 1389-1398. doi:10.1016/S0006-3223(03)00465-7
20. Heinrichs, M., von Dawans, B., & Domes, G. (2009). Oxytocin, vasopressin, and human social behavior. Frontiers in Neuroendocrinology, 30, 548-557. doi:10.1016/j.yfrne.2009.05.005
21. Hek, K., Direk, N., Newson, R. S., Hofman, A., Hoogendijk, W. J. G., Mulder, C. L., & Tiemeier, H. (2013). Anxiety disorders and salivary cortisol levels in older adults: A population-based study. Psychoneuroendocrinology, 38, 300-305. doi:10.1016/j.psyneuen.2012.06.006
22. Hofmann, S. G., Heinrichs, N., & Moscovitch, D. A. (2004). The nature and expression of social phobia: Toward a new classification. Clinical Psychology Review, 24, 769-797. doi:10.1016/j.cpr.2004.07.004
23. Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., … Wang, P. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. American Journal of Psychiatry, 167, 748-751. doi:10.1176/appi.ajp.2010.09091379
24. Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435, 673-676. doi:10.1038/nature03701
25. Kumsta, R., Heinrichs, M. (2013). Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Current Opinion in Neurobiology, 23, 11-16. doi:10.1016/j.conb.2012.09.004
26. Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., … Nathan, P. J. (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology, 35, 2403-2413. doi:10.1038/npp.2010.123
27. Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., … Nathan, P. J. (2011). Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. International Journal of Neuropsychopharmacology, 15, 883-896. doi:10.1017/S1461145711001489
28. Liebowitz, M. R. (1987). Social phobia. Modern Problems of Pharmacopsychiatry, 22, 141-173.
29. MacDonald, K. S. (2013). Sex, receptors, and attachment: A review of individual factors influencing response to oxytocin. Frontiers in Neuroscience, 6, 194. Retrieved from http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00194/full
30. Mattick, R. P., & Clarke, J. C. (1998). Development and validation of measures of social phobia scrutiny fear and social interaction anxiety. Behaviour Research and Therapy, 36, 455-470. doi:10.1016/S0005-7967(97)10031-6
31. Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nature Reviews Neuroscience, 19, 524-538. doi:10.1038/nrn3044
32. Niciu, M. J., Mathews, D. C., Nugent, A. C., Ionescu, D. F., Furey, M. L., Richards, E. M., … Zarate, C. A. (2013). Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants. Depression and Anxiety. Advance online publication. doi:10.1002/da.22224
33. Posner, M. I. (1980). Orienting of attention. Quarterly Journal of Experimental Psychology, 32, 3-25. doi:10.1080/00335558008248231
34. Posner, M. I., Snyder, C. R., & Davidson, B. J. (1980). Attention and the detection of signals. Journal of Experimental Psychology: General, 109, 160-174. doi:10.1037/0096-3445.109.2.160
35. Russ, S. J., Herbert, J., Cooper, P., Gunnar, M. R., Goodyer, I., Croudace, T., & Murray, L. (2012). Cortisol levels in response to starting school in children at increased risk for social phobia. Psychoneuroendocrinology, 37, 462-474. doi:10.1016/j.psyneuen.2011.07.014
36. Sanislow, C. A., Pine, D. S., Quinn, K. J., Kozak, M. J., Garvey, M. A., Heinssen, R. K., … Cuthbert, B. N. (2010). Developing constructs for psychopathology research: Research domain criteria. Journal of Abnormal Psychology, 119, 631-639. doi:10.1037/a0020909
37. Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology, 54, 1063-1070. doi:10.1037/0022-3514.54.6.1063
38. Williams, K. D., Cheung, C. K. T., & Choi, W. (2000). Cyberostracism: Effects of being ignored over the Internet. Journal of Personality and Social Psychology, 79, 748-762. doi:10.1037/0022-3514.79.5.748
39. Williams, K. D., & Jarvis, B. (2006). Cyberball: A program for use in research on interpersonal ostracism and acceptance. Behavior Research Methods, 38, 174-180. doi:10.3758/BF03192765