A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells

Molecular and Cellular Endocrinology

Volumn 471, Issue , 2018, Pages 42-50

  Frahm, Krystle A ^a   Waldman, Jacob K ^a   Luthra, Soumya ^a   Rudine, Anthony C ^b   Monaghan Nichols, A Paula ^a   Chandran, Uma R ^a   DeFranco, Donald B ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Cortex; Development; Glucocorticoids; Hypothalamus; Neural stem cells; Sex differences

Indexed keywords

DEXAMETHASONE; LONG UNTRANSLATED RNA; TRANSCRIPTOME; MESSENGER RNA;

ANIMAL CELL; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN REGION; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; ERRA GENE; FEMALE; FETUS; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GR GENE; HYPOTHALAMUS; LXRB GENE; MALE; MOUSE; NEURAL STEM CELL; NONHUMAN; NUCLEAR REPROGRAMMING; NUR77 GENE; PPARG GENE; PRENATAL PERIOD; PRIORITY JOURNAL; RARA GENE; REV ERBA A GENE; REV ERBA B GENE; REVIEW; RNA SEQUENCE; RORA GENE; RORB GENE; RXRA GENE; RXRB GENE; SEQUENCE ANALYSIS; SEX DIFFERENCE; TF1 GENE; TF2 GENE; TLX GENE; TR2 GENE; TR4 GENE; TR4A GENE; TR4B GENE; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; EMBRYOLOGY; GENETICS; MAMMALIAN EMBRYO; METABOLISM; SEXUAL CHARACTERISTICS;

ANIMALS; CEREBRAL CORTEX; DEXAMETHASONE; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPOTHALAMUS; MALE; MICE, INBRED C57BL; NEURAL STEM CELLS; RNA, MESSENGER; SEQUENCE ANALYSIS, RNA; SEX CHARACTERISTICS; TRANSCRIPTOME;

EID: 85019979530     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2017.05.026     Document Type: Review

References (30)

1. Altman, J., Bayer, S.A., The development of the rat hypothalamus. Adv. Anat. Embryol. Cell Biol. 100 (1986), 1–178.
2. Ayoub, A.E., Oh, S., Xie, Y., Leng, J., Cotney, J., Dominguez, M.H., Noonan, J.P., Rakic, P., Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 14950–14955, 10.1073/pnas.1112213108.
3. Becnel, L.B., Ochsner, S.A., Darlington, Y.F., McOwiti, A., Kankanamge, W.H., Dehart, M., Naumov, A., McKenna, N.J., Discovering relationships between nuclear receptor signaling pathways, genes, and tissues in transcriptomine. Sci. Signal, 10, 2017, 476, 10.1126/scisignal.aah6275.
4. Boardman, J.P., Walley, A., Ball, G., Takousis, P., Krishnan, M.L., Hughes-Carre, L., Aljabar, P., Serag, A., King, C., Merchant, N., Srinivasan, L., Froguel, P., Hajnal, J., Rueckert, D., Counsell, S., Edwards, A.D., Common genetic variants and risk of brain injury after preterm birth. Pediatrics 133 (2014), e1655–e1663, 10.1542/peds.2013-3011.
5. Carson, R., Monaghan-Nichols, A.P., DeFranco, D.B., Rudine, A.C., Effects of antenatal glucocorticoids on the developing brain. Steroids 114 (2016), 25–32, 10.1016/j.steroids.2016.05.012.
6. Crowley, P.A., Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994. Am. J. Obstet. Gynecol. 173 (1995), 322–335.
7. Frahm, K.A., Peffer, M.E., Zhang, J.Y., Luthra, S., Chakka, A.B., Couger, M.B., Chandran, U.R., Monaghan, A.P., DeFranco, D.B., Research Resource: the dexamethasone transcriptome in hypothalamic embryonic neural stem cells. Mol. Endocrinol. 30 (2016), 144–154, 10.1210/me.2015-1258.
8. Hufgard, J.R., Williams, M.T., Skelton, M.R., Grubisha, O., Ferreira, F.M., Sanger, H., Wright, M.E., Reed-Kessler, T.M., Rasmussen, K., Duman, R.S., Vorhees, C.V., Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a. Psychopharmacol. [Epub ahead print], 2017, 10.1007/s00213-017-4587-8.
9. Karemaker, R., Kavelaars, A., ter Wolbeek, M., Tersteeg-Kamperman, M., Baerts, W., Veen, S., Samsom, J.F., Visser, G.H., van Bel, F., Heijnen, C.J., Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age. Pediatrics 121 (2008), e870–e878, 10.1542/peds.2007-2454.
10. Lv, J., Cui, W., Liu, H., He, H., Xiu, Y., Guo, J., Liu, H., Liu, Q., Zeng, T., Chen, Y., Zhang, Y., Wu, Q., Identification and characterization of long non-coding RNAs related to mouse embryonic brain development from available transcriptomic data. PLoS ONE, 8, 2013, e71152, 10.1371/journal.pone.0071152.
11. Mahfouz, A., Lelieveldt, B.P., Grefhorst, A., van Weert, L.T., Mol, I.M., Sips, H.C., van den Heuvel, J.K., Datson, N.A., Visser, J.A., Reinders, M.J., Meijer, O.C., Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), 2738–2743, 10.1073/pnas.1520376113.
12. Moisiadia, V.G., Matthews, S.G., Glucocorticoids and fetal programming part 1: outcomes. Nat. Rev. Endocrinol. 10 (2014), 391–402, 10.1038/nrendo.2014.73.
13. Molyneaux, B.J., Arlotta, P., Menezes, J.R., Macklis, J.D., Neuronal sub-type specification in the cerebral cortex. Nat. Rev. Neurosci. 8 (2007), 427–437, 10.1038/nrn2151.
14. Park, O.H., Park, J., Yu, M., An, H.T., Ko, J., Kim, Y.K., Identification and molecular characterization of cellular factors required for glucocorticoid receptor-mediated mRNA decay. Genes Dev. 30 (2016), 2093–2105, 10.1101/gad.286484.116.
15. Peffer, M.E., Chandran, U.R., Luthra, S., Volonte, D., Garabedian, M.J., Monaghan, A.P., DeFranco, D.B., Caveolin-1 regulates genomic action of the glucocorticoid receptor in neural stem cells. Mol. Cell Biol. 34 (2014), 2611–2623, 10.1128/MCB.01121-13.
16. Peffer, M.E., Zhang, J.Y., Umfrey, L., Rudine, A.C., Monaghan, A.P., DeFranco, D.B., Minireview: the impact of antenatal therapeutic synthetic glucocorticoids on the developing fetal brain. Mol. Endocrinol. 29 (2015), 658–666, 10.1210/me.2015-1042.
17. Rakic, P., Specification of cerebral cortical areas. Science 241 (1988), 170–176.
18. Rakic, P., Lombroso, P.J., Development of the cerebral cortex: 1. Forming the cortical structure. J. Am. Acad. Adolesc. Psychiatry 37 (1998), 116–117, 10.1097/00004583-199801000-00026.
19. Reinhardt, R.R., Bondy, C.A., Differential cellular pattern of gene expression for two distinct cGMP-inhibited cyclic nucleotide phosphodiesterases in developing and mature rat brain. Neuroscience 72 (1996), 567–578.
20. Roberts, D., Dalziel, S., Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev., 19, 2006, CD004454, 10.1002/14651858.CD004454.pub2.
21. Rubenstein, J.L., Annual Research Review: development of the cerebral cortex: implications for neurodevelopmental disorders. J. Child. Psychol. Psychiatry 52 (2011), 339–355, 10.1111/j.1469-7610.2010.02307.x.
22. Salvi, R., Arsenijevic, Y., Giacomini, M., Rey, J.P., Voirol, M.J., Gaillard, R.C., Risold, P.Y., Pralong, F., The fetal hypothalamus has the potential to generate cells with a gonadotropin releasing hormone (GnRH) phenotype. PLoS One, 4, 2009, e4392, 10.1371/journal.pone.0004392.
23. Samarasinghe, R.A., Di Maio, R., Volonte, D., Galbiati, F., Lewis, M., Romero, G., DeFranco, D.B., Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation. Proc. Natl. Acad. Sci. USA. 108 (2011), 16657–16662, 10.1073/pnas.1102821108.
24. Schmitt, A., Malchow, B., Hasan, A., Falkai, P., The impact of environmental factors in severe psychiatric disorders. Front. Neurosci., 8, 2014, 19, 10.3389/fnins.2014.00019.
25. Shimogori, T., Lee, D.A., Miranda-Angulo, A., Yang, Y., Wang, H., Jiang, L., Yoshida, A.C., Kataoka, A., Mashiko, H., Avetisyan, M., Qi, L., Qian, J., Blackshaw, S., A genomic atlas of mouse hypothalamic development. Nat. Neurosci. 13 (2010), 767–775, 10.1038/nn.2545.
26. Sim, K., Chan, W.Y., Woon, P.S., Low, H.Q., Lim, L., Yang, G.L., Lee, J., Chong, S.A., Sitoh, Y.Y., Chan, Y.H., Liu, J., Tan, E.C., Williams, H., Nowinski, W.L., ARVCF genetic influences on neurocognitive and neuroanatomical intermediate phenotypes in Chinese patients with schizophrenia. J. Clin. Psychiatry 73 (2012), 320–326, 10.4088/JCP.10m06491.
27. Siuciak, J.A., McCarthy, S.A., Chapin, D.S., Reed, T.M., Vorhees, C.V., Repaske, D.R., Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme. Neuropharmacology 53 (2007), 113–124, 10.1016/j.neuropharm.2007.04.009.
28. Sun, X.Y., Hayashi, Y., Xu, S., Kanou, Y., Takagishi, Y., Tang, Y.P., Murata, Y., Inactivation of the Rcan2 gene in mice ameliorates the age- and diet-induced obesity by causing a reduction in food intake. PLoS One, 6, 2011, e14605, 10.1371/journal.pone.0014605.
29. Ulfig, N., Chan, W.Y., Expression of ARVCF in the human ganglionic eminence during fetal development. Dev. Neurosci. 26 (2004), 38–44, 10.1159/000080710.
30. Wyrwoll, C.S., Homes, M.C., Prenatal excess glucocorticoids exposure and adult affective disorders: a role for serotonergic and catecholamine pathways. Neuroendocrinology 95 (2012), 47–55, 10.1159/000331345.