Obesity and survival in critically ill patients with acute respiratory distress syndrome: A paradox within the paradox

Critical Care

Volumn 21, Issue 1, 2017, Pages

  Ball, Lorenzo ^a   Serpa Neto, Ary ^b   Pelosi, Paolo ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

Author keywords

ARDS; ICU; Obesity

Indexed keywords

CYTOKINE;

ADULT RESPIRATORY DISTRESS SYNDROME; AGE; ARTIFICIAL VENTILATION; BODY MASS; CLINICAL OUTCOME; COHORT ANALYSIS; COMORBIDITY; CRITICALLY ILL PATIENT; DECUBITUS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; EDITORIAL; ENDOTOXEMIA; GLYCEMIC CONTROL; HIGH INCOME COUNTRY; HIGH RISK PATIENT; HOSPITAL ADMISSION; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; LUNG COMPLIANCE; MACROPHAGE; META ANALYSIS (TOPIC); METABOLICALLY BENIGN OBESITY; MORTALITY RISK; OBESITY; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY FUNCTION; RETROSPECTIVE STUDY; SEPSIS; SEPTIC SHOCK; TREND STUDY; UNDERWEIGHT; VENTILATOR INDUCED LUNG INJURY; APACHE; COMPLICATION; CRITICAL ILLNESS; MORTALITY; ORGANIZATION AND MANAGEMENT; RISK FACTOR; STATISTICS AND NUMERICAL DATA; SURVIVOR;

APACHE; BODY MASS INDEX; CRITICAL ILLNESS; HUMANS; INTENSIVE CARE UNITS; OBESITY; RESPIRATORY DISTRESS SYNDROME, ADULT; RISK FACTORS; SURVIVORS;

EID: 85019951396     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-017-1682-5     Document Type: Editorial

References (22)

1. Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in obesity among adults in the United States, 2005 to 2014. JAMA. 2016;315:2284.
2. Lewandowski K, Lewandowski M. Intensive care in the obese. Best Pract Res Clin Anaesthesiol. 2011;25:95-108.
3. Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med. 2006;355:763-78.
4. Arabi YM, Dara SI, Tamim HM, Rishu AH, Bouchama A, Khedr MK, et al. Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study. Crit Care Lond Engl. 2013;17:R72.
5. Ball L, Sutherasan Y, Pelosi P. Monitoring respiration: what the clinician needs to know. Best Pract Res Clin Anaesthesiol. 2013;27:209-23.
6. Pelosi P, Gregoretti C. Perioperative management of obese patients. Best Pract Res Clin Anaesthesiol. 2010;24:211-25.
7. Ni Y-N, Luo J, Yu H, Wang Y-W, Hu Y-H, Liu D, et al. Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis. Crit Care Lond Engl. 2017;21:36.
8. Zhi G, Xin W, Ying W, Guohong X, Shuying L. "Obesity paradox" in acute respiratory distress syndrome: a systematic review and meta-analysis. PLoS One. 2016;11, e0163677.
9. O'Brien JM, Phillips GS, Ali NA, Lucarelli M, Marsh CB, Lemeshow S. Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med. 2006;34:738-44.
10. Gong MN, Bajwa EK, Thompson BT, Christiani DC. Body mass index is associated with the development of acute respiratory distress syndrome. Thorax. 2010;65:44-50.
11. Morris AE, Stapleton RD, Rubenfeld GD, Hudson LD, Caldwell E, Steinberg KP. The association between body mass index and clinical outcomes in acute lung injury. Chest. 2007;131:342-8.
12. Soto GJ, Frank AJ, Christiani DC, Gong MN. Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med. 2012;40:2601-8.
13. Stapleton RD, Dixon AE, Parsons PE, Ware LB, Suratt BT, Acute Respiratory Distress Syndrome Network NHLBI. The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest. 2010;138:568-77.
14. Egger M, Schneider M, Davey SG. Spurious precision? Meta-analysis of observational studies. BMJ. 1998;316:140-4.
15. Anzueto A, Frutos-Vivar F, Esteban A, Bensalami N, Marks D, Raymondos K, et al. Influence of body mass index on outcome of the mechanically ventilated patients. Thorax. 2011;66:66-73.
16. Bustamante AF. Adipose-lung cell crosstalk in the obesity-ARDS paradox. J Pulm Respir Med. 2013;3:144. doi: 10.4172/2161-105X.
17. Teoh N. Low-dose TNF-α protects against hepatic ischemia-reperfusion injury in mice: Implications for preconditioning. Hepatology. 2003;37:118-28.
18. Shah R, Hinkle CC, Haris L, Shah R, Mehta NN, Putt ME, et al. Adipose genes down-regulated during experimental endotoxemia are also suppressed in obesity. J Clin Endocrinol Metab. 2012;97:E2152-9.
19. Langouche L, Marques MB, Ingels C, Gunst J, Derde S, Vander Perre S, et al. Critical illness induces alternative activation of M2 macrophages in adipose tissue. Crit Care. 2011;15:R245.
20. Durward CM, Hartman TJ, Nickols-Richardson SM. All-cause mortality risk of metabolically healthy obese individuals in NHANES III. J Obes. 2012;2012:1-12.
21. Pompilio CE, Pelosi P, Castro MG. The bariatric patient in the intensive care unit: pitfalls and management. Curr Atheroscler Rep. 2016;18:55.
22. Soubani AO, Chen W, Jang H. The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus. Heart Lung: J Acute Crit Care. 2015;44(5):441-7.