Can all bulk-phase reactions be accelerated in microdroplets?

Analyst

Volumn 142, Issue 9, 2017, Pages 1399-1402

  Banerjee, Shibdas ^a   Gnanamani, Elumalai ^a   Yan, Xin ^a   Zare, Richard N ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; REACTION ANALYSIS; SCALE UP; SYNTHESIS;

EID: 85019903317     PISSN: 00032654     EISSN: 13645528     Source Type: Journal    
DOI: 10.1039/c6an02225a     Document Type: Review

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26. -1 reagent mixture solution flow with a coaxial sheath gas (nitrogen) flow of 120 psi at different spray voltages (Fig. 1d-f). The microdroplets were allowed to traverse through a grounded glass column bottom sealed with silica gel material from where the product and unreacted starting materials were collected in dichloromethane and analyzed by GC-MS. The droplet lifetime was also allowed to change by varying the column lengths (10 cm and 40 cm), solution flow (5-30 μL), and sheath gas flow (100-150 psi). None of these efforts helped in detecting the desired product B. Rather, ester (A) hydrolysis was evident in all cases, similar to Fig. 1d-f