Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis

Cell

Volumn 169, Issue 6, 2017, Pages 1090-1104.e13

  Gou, Lan Tao ^a,f   Kang, Jun Yan ^a   Dai, Peng ^a   Wang, Xin ^a   Li, Feng ^a   Zhao, Shuang ^a   Zhang, Man ^a   Hua, Min Min ^a,b   Lu, Yi ^b   Zhu, Yong ^c   Li, Zheng ^c   Chen, Hong ^d   Wu, Li Gang ^a   Li, Dangsheng ^e   Fu, Xiang Dong ^f   Li, Jinsong ^a,g   Shi, Hui Juan ^b   Liu, Mo Fang ^a,b,g  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d Histology and Embryology   (United States)

^e Chinese Academy of Sciences   (China)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g SHANGHAITECH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; PIWI INTERACTING RNA; PIWI PROTEIN; PROTAMINE; UBIQUITIN PROTEIN LIGASE; ARGONAUTE PROTEIN; CHROMATIN; DNA BINDING PROTEIN; PIWIL1 PROTEIN, HUMAN; RNF8 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AZOOSPERMIA; CONTROLLED STUDY; CYTOPLASM; EMBRYO; GENETIC DISORDER; GERMLINE MUTATION; HISTONE UBIQUITINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPERMATID; SPERMATOGENESIS; ANIMAL; CHROMATIN; DISEASE MODEL; DNA MUTATIONAL ANALYSIS; FEMALE; GENE TARGETING; GENETICS; INTRON; METABOLISM; MUTATION; PEDIGREE; UBIQUITINATION;

ANIMALS; ARGONAUTE PROTEINS; AZOOSPERMIA; CHROMATIN; DISEASE MODELS, ANIMAL; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FEMALE; GENE KNOCK-IN TECHNIQUES; HISTONES; HUMANS; INTRONS; MALE; MICE; MUTATION; PEDIGREE; PROTAMINES; PROTEOLYSIS; SPERMATOGENESIS; UBIQUITINATION;

EID: 85019624673     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.04.034     Document Type: Article

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