True Anemia-Red Blood Cell Volume Deficit-in Heart Failure: A Systematic Review

Circulation: Heart Failure

Volumn 10, Issue 5, 2017, Pages

  Montero, David ^a   Lundby, Carsten ^b   Ruschitzka, Frank ^a   Flammer, Andreas J ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

anemia; heart failure; hemodilution; hemoglobin; plasma volume

Indexed keywords

FERRITIN; HEMOGLOBIN;

ANEMIA; ARTICLE; BLOOD VOLUME; BODY MASS; ERYTHROCYTE VOLUME; FLUID RETENTION; HEART FAILURE; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; PHENOTYPE; PLASMA VOLUME; PRIORITY JOURNAL; SEX DIFFERENCE; SYSTEMATIC REVIEW; BLOOD; COMPLICATION; PHYSIOLOGY; RISK FACTOR;

ANEMIA; ERYTHROCYTE VOLUME; HEART FAILURE; HUMANS; RISK FACTORS;

EID: 85019587840     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.116.003610     Document Type: Article

References (50)

1. Miller WL. Fluid volume overload and congestion in heart failure: time to reconsider pathophysiology and how volume is assessed. Circ Heart Fail. 2016;9:e002922. doi: 10.1161/CIRCHEARTFAILURE.115.002922.
2. Guyton AC, Hall JE. The Circulation. Cardiac Failure Textbook of Medical Physiology. 11th ed. Philadelphia, PA: Elsevier; 2011: 258-268.
3. Seymour WB, Pritchard WH, Longley LP, Hayman JM. Cardiac output, blood and interstitial fluid volumes, total circulating serum protein, and kidney function during cardiac failure and after improvement. J Clin Invest. 1942;21:229-240. doi: 10.1172/JCI101294.
4. Watson RD, Gibbs CR, Lip GY. ABC of heart failure. Clinical features and complications. BMJ. 2000;320:236-239.
5. Kaplan E, Puestow RC, Baker LA, Kruger S. Blood volume in congestive heart failure as determined with iodinated human serum albumin. Am Heart J. 1954;47:824-838.
6. World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. 2011. Available at http://www.who.int/iris/handle/10665/85839. Accessed April 21, 2017.
7. Groenveld HF, Januzzi JL, Damman K, van Wijngaarden J, Hillege HL, van Veldhuisen DJ, van der Meer P. Anemia and mortality in heart failure patients a systematic review and meta-analysis. J Am Coll Cardiol. 2008;52:818-827. doi: 10.1016/j.jacc.2008.04.061.
8. Androne AS, Katz SD, Lund L, LaManca J, Hudaihed A, Hryniewicz K, Mancini DM. Hemodilution is common in patients with advanced heart failure. Circulation. 2003;107:226-229.
9. Miller WL, Mullan BP. Peripheral venous hemoglobin and red blood cell mass mismatch in volume overload systolic heart failure: implications for patient management. J Cardiovasc Transl Res. 2015;8:404-410. doi: 10.1007/s12265-015-9650-4.
10. Borovka M, Teruya S, Alvarez J, Helmke S, Maurer MS. Differences in blood volume components between hyporesponders and responders to erythropoietin alfa: the heart failure with preserved ejection fraction (HFPEF) anemia trial. J Card Fail. 2013;19:685-691. doi: 10.1016/j. cardfail.2013.08.508.
11. Kotecha D, Ngo K, Walters JA, Manzano L, Palazzuoli A, Flather MD. Erythropoietin as a treatment of anemia in heart failure: systematic review of randomized trials. Am Heart J. 2011;161:822-831.e2. doi: 10.1016/j.ahj.2011.02.013.
12. Swedberg K, Young JB, Anand IS, Cheng S, Desai AS, Diaz R, Maggioni AP, McMurray JJ, O'Connor C, Pfeffer MA, Solomon SD, Sun Y, Tendera M, van Veldhuisen DJ; RED-HF Committees; RED-HF Investigators. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med. 2013;368:1210-1219. doi: 10.1056/NEJMoa1214865.
13. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P; Authors/Task Force Members. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37:2129-2200. doi: 10.1093/eurheartj/ehw128.
14. Kalra PR, Anagnostopoulos C, Bolger AP, Coats AJ, Anker SD. The regulation and measurement of plasma volume in heart failure. J Am Coll Cardiol. 2002;39:1901-1908.
15. Feigenbaum MS, Welsch MA, Mitchell M, Vincent K, Braith RW, Pepine CJ. Contracted plasma and blood volume in chronic heart failure. J Am Coll Cardiol. 2000;35:51-55.
16. Abramov D, Cohen RS, Katz SD, Mancini D, Maurer MS. Comparison of blood volume characteristics in anemic patients with low versus preserved left ventricular ejection fractions. Am J Cardiol. 2008;102:1069-1072. doi: 10.1016/j.amjcard.2008.05.058.
17. Adlbrecht C, Kommata S, Hülsmann M, Szekeres T, Bieglmayer C, Strunk G, Karanikas G, Berger R, Mörtl D, Kletter K, Maurer G, Lang IM, Pacher R. Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume. Eur Heart J. 2008;29:2343-2350. doi: 10.1093/eurheartj/ehn359.
18. Bonfils PK, Damgaard M, Taskiran M, Goetze JP, Norsk P, Gadsbøll N. Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure. Eur J Heart Fail. 2010;12:995-1001. doi: 10.1093/eurjhf/hfq100.
19. Cohen RS, Karlin P, Yushak M, Mancini D, Maurer MS. The effect of erythropoietin on exercise capacity, left ventricular remodeling, pressure- volume relationships, and quality of life in older patients with anemia and heart failure with preserved ejection fraction. Congest Heart Fail. 2010;16:96-103. doi: 10.1111/j.1751-7133.2009.00135.x.
20. Damgaard M, Norsk P, Gustafsson F, Kanters JK, Christensen NJ, Bie P, Friberg L, Gadsbøll N. Hemodynamic and neuroendocrine responses to changes in sodium intake in compensated heart failure. Am J Physiol Regul Integr Comp Physiol. 2006;290:R1294-R1301. doi: 10.1152/ajpregu.00738.2005.
21. Gibson JG, Evans WA. Clinical studies of the blood volume. III. Changes in blood volume, venous pressure and blood velocity rate in chronic congestive heart failure. J Clin Invest. 1937;16:851-858. doi: 10.1172/JCI100911.
22. James KB, McCarthy PM, Jaalouk S, Bravo EL, Betkowski A, Thomas JD, Nakatani S, Fouad-Tarazi FM. Plasma volume and its regulatory factors in congestive heart failure after implantation of long-term left ventricular assist devices. Circulation. 1996;93:1515-1519.
23. Kubo SH, Clark M, Laragh JH, Borer JS, Cody RJ. Identification of normal neurohormonal activity in mild congestive heart failure and stimulating effect of upright posture and diuretics. Am J Cardiol. 1987;60:1322-1328.
24. Miller WL, Mullan BP. Understanding the heterogeneity in volume overload and fluid distribution in decompensated heart failure is key to optimal volume management: role for blood volume quantitation. JACC Heart Fail. 2014;2:298-305. doi: 10.1016/j.jchf.2014.02.007.
25. Miller WL, Mullan BP. Volume overload profiles in patients with preserved and reduced ejection fraction chronic heart failure: are there differences? A Pilot Study. JACC Heart Fail. 2016;4:453-459. doi: 10.1016/j.jchf.2016.01.005.
26. Reilly WA, French RM, Lau FY, Scott KG, White WE. Whole blood volume determined by radiochromium-tagged red cells; comparative studies on normal and congestive heart failure patients. Circulation. 1954;9:571-580.
27. Feldschuh J, Enson Y. Prediction of the normal blood volume. Relation of blood volume to body habitus. Circulation. 1977;56:605-612.
28. Feldschuh J, Katz S. The importance of correct norms in blood volume measurement. Am J Med. Sci. 2007;334:41-46. doi: 10.1097/MAJ.0b013e318063c707.
29. Dworkin HJ, Premo M, Dees S. Comparison of red cell and whole blood volume as performed using both chromium-51-tagged red cells and iodine-125-tagged albumin and using I-131-tagged albumin and extrapolated red cell volume. Am J Med Sci. 2007;334:37-40. doi: 10.1097/MAJ.0b013e3180986276.
30. Shah B, Sucher K, Hollenbeck CB. Comparison of ideal body weight equations and published height-weight tables with body mass index tables for healthy adults in the United States. Nutr Clin Pract. 2006;21:312-319. doi: 10.1177/0115426506021003312.
31. Fairbanks VF, Tefferi A. Normal ranges for packed cell volume and hemoglobin concentration in adults: relevance to 'apparent polycythemia'. Eur J Haematol. 2000;65:285-296.
32. Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure. Circulation. 2003;107:223-225.
33. Makipour S, Kanapuru B, Ershler WB. Unexplained anemia in the elderly. Semin Hematol. 2008;45:250-254.
34. Robinson B, Artz AS, Culleton B, Critchlow C, Sciarra A, Audhya P. Prevalence of anemia in the nursing home: contribution of chronic kidney disease. J Am Geriatr Soc. 2007;55:1566-1570. doi: 10.1111/j.1532-5415.2007.01389.x.
35. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Borenstein J. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol. 2002;39:1780-1786.
36. Kosiborod M, Curtis JP, Wang Y, Smith GL, Masoudi FA, Foody JM, Havranek EP, Krumholz HM. Anemia and outcomes in patients with heart failure: a study from the National Heart Care Project. Arch Intern Med. 2005;165:2237-2244. doi: 10.1001/archinte.165.19.2237.
37. Zhang QL, Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: systematic review. BMC Public Health. 2008;8:117. doi: 10.1186/1471-2458-8-117.
38. Cleland JG, Zhang J, Pellicori P, Dicken B, Dierckx R, Shoaib A, Wong K, Rigby A, Goode K, Clark AL. Prevalence and outcomes of anemia and hematinic deficiencies in patients with chronic heart failure. JAMA Cardiol. 2016;1:539-547. doi: 10.1001/jamacardio.2016.1161.
39. Jankowska EA, Tkaczyszyn M, Suchocki T, Drozd M, von Haehling S, Doehner W, Banasiak W, Filippatos G, Anker SD, Ponikowski P. Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials. Eur J Heart Fail. 2016;18:786-795. doi: 10.1002/ejhf.473.
40. Berry C, Hogg K, Norrie J, Stevenson K, Brett M, McMurray J. Heart failure with preserved left ventricular systolic function: a hospital cohort study. Heart. 2005;91:907-913. doi: 10.1136/hrt.2004.041996.
41. Klapholz M, Maurer M, Lowe AM, Messineo F, Meisner JS, Mitchell J, Kalman J, Phillips RA, Steingart R, Brown EJ Jr, Berkowitz R, Moskowitz R, Soni A, Mancini D, Bijou R, Sehhat K, Varshneya N, Kukin M, Katz SD, Sleeper LA, Le Jemtel TH; New York Heart Failure Consortium. Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: results of the New York Heart Failure Registry. J Am Coll Cardiol. 2004;43:1432-1438. doi: 10.1016/j. jacc.2003.11.040.
42. Borlaug BA. The pathophysiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2014;11:507-515. doi: 10.1038/nrcardio.2014.83.
43. Kitzman DW, Herrington DM, Brubaker PH, Moore JB, Eggebeen J, Haykowsky MJ. Carotid arterial stiffness and its relationship to exercise intolerance in older patients with heart failure and preserved ejection fraction. Hypertension. 2013;61:112-119. doi: 10.1161/HYPERTENSIONAHA.111.00163.
44. Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004;43:1239-1245. doi: 10.1161/01. HYP.0000128420.01881.aa.
45. Dalos D, Mascherbauer J, Zotter-Tufaro C, Duca F, Kammerlander AA, Aschauer S, Bonderman D. Functional status, pulmonary artery pressure, and clinical outcomes in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2016;68:189-199. doi: 10.1016/j.jacc.2016.04.052.
46. Montero D, Diaz-Cañestro C, Keiser S, Lundby C. Arterial stiffness is strongly and negatively associated with the total volume of red blood cells. Int J Cardiol. 2016;221:77-80. doi: 10.1016/j.ijcard.2016.06.265.
47. Kirsch K, Risch WD, Mund U, Röcker L, Stosoy H. Low pressure system and blood volume regulating hormones after prolonged exercise. In: Howald H, Poortmans JR, eds. Metabolic Adaptation to Prolonged Physical Exercise. Lausanne, Switzerland; 1975: 315-321.
48. Hashimoto J, Ito S. Aortic blood flow reversal determines renal function: potential explanation for renal dysfunction caused by aortic stiffening in hypertension. Hypertension. 2015;66:61-67. doi: 10.1161/HYPERTENSIONAHA.115.05236.
49. Means RT Jr. Pathogenesis of the anemia of chronic disease: a cytokine- mediated anemia. Stem Cells. 1995;13:32-37. doi: 10.1002/stem.5530130105.
50. Lundby C, Montero D, Joyner M. Biology of VO2 max: looking under the physiology lamp [published online ahead of print November 7, 2016]. Acta Physiol (Oxf). 2016. doi: 10.1111/apha.12827.