Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: Randomized, sham-controlled cross-over trial

European Heart Journal

Volumn 38, Issue 15, 2017, Pages 1159-1168

  Ulrich, Silvia ^a   Hasler, Elisabeth D ^a   Saxer, Stephanie ^a   Furian, Michael ^a   Müller Mottet, Severine ^a   Keusch, Stephan ^a   Bloch, Konrad E ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Exercise; Oxygen therapy; Precapillary pulmonary hypertension; Pulmonary hypertension

Indexed keywords

ENDOTHELIN RECEPTOR ANTAGONIST; GUANYLATE CYCLASE ACTIVATOR; PHOSPHODIESTERASE V INHIBITOR; CARBON DIOXIDE; OXYGEN;

ADULT; AMBIENT AIR; ARTERIAL GAS; ARTERIAL OXYGEN SATURATION; ARTERIAL OXYGEN TENSION; ARTICLE; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CROSSOVER PROCEDURE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; EXERCISE; EXERCISE TEST; FEMALE; HEART INDEX; HEART OUTPUT; HEART RATE; HEMOGLOBIN DETERMINATION; HUMAN; HYPEROXIA; LUNG ANGIOGRAPHY; LUNG DEAD SPACE; LUNG DIFFUSION CAPACITY; LUNG GAS EXCHANGE; LUNG MINUTE VOLUME; LUNG VASCULAR RESISTANCE; LUNG WEDGE PRESSURE; MALE; MIDDLE AGED; NEAR INFRARED SPECTROSCOPY; OUTCOME ASSESSMENT; OXYGEN CONCENTRATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; PULSE OXIMETRY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SPIROMETRY; TIDAL VOLUME; TISSUE OXYGENATION; TOTAL LUNG CAPACITY; BLOOD; EXERCISE TOLERANCE; HYPERTENSION, PULMONARY; PARTIAL PRESSURE; PATHOPHYSIOLOGY; PHYSIOLOGY;

CARBON DIOXIDE; CROSS-OVER STUDIES; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART RATE; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; PULMONARY GAS EXCHANGE; SINGLE-BLIND METHOD;

EID: 85019400089     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehx099     Document Type: Article

References (29)

1. Galie N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M, Aboyans V, Vaz Carneiro A, Achenbach S, Agewall S, Allanore Y, Asteggiano R, Paolo Badano L, Albert Barbera J, Bouvaist H, Bueno H, Byrne RA, Carerj S, Castro G, Erol C, Falk V, Funck-Brentano C, Gorenflo M, Granton J, Iung B, Kiely DG, Kirchhof P, Kjellstrom B, Landmesser U, Lekakis J, Lionis C, Lip GY, Orfanos SE, Park MH, Piepoli MF, Ponikowski P, Revel MP, Rigau D, Rosenkranz S, Voller H, Luis Zamorano J. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J 2016;37:67-119.
2. Cenedese E, Speich R, Dorschner L, Ulrich S, Maggiorini M, Jenni R, Fischler M. Measurement of quality of life in pulmonary hypertension and its significance. Eur Respir J 2006;28:808-815.
3. Cima K, Twiss J, Speich R, McKenna SP, Grunig E, Kahler CM, Ehlken N, Treder U, Crawford SR, Huber LC, Ulrich S. The German adaptation of the Cambridge pulmonary hypertension outcome review (CAMPHOR). Health Qual Life Outcomes 2012;10:110.
4. Sun XG, Hansen JE, Oudiz RJ, Wasserman K. Exercise pathophysiology in patients with primary pulmonary hypertension. Circulation 2001;104:429-435.
5. Wensel R, Jilek C, Dorr M, Francis DP, Stadler H, Lange T, Blumberg F, Opitz C, Pfeifer M, Ewert R. Impaired cardiac autonomic control relates to disease severity in pulmonary hypertension. Eur Respir J 2009;34:895-901.
6. Naeije R, Chesler N. Pulmonary circulation at exercise. Compr Physiol 2012;2:711-741.
7. Theodore J, Robin ED, Morris AJ, Burke CM, Jamieson SW, Van Kessel A, Stinson EB, Shumway NE. Augmented ventilatory response to exercise in pulmonary hypertension. Chest 1986;89:39-44.
8. Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM. Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. J Am Coll Cardiol 2013;62:D22-D33.
9. Lewis GD, Bossone E, Naeije R, Grunig E, Saggar R, Lancellotti P, Ghio S, Varga J, Rajagopalan S, Oudiz R, Rubenfire M. Pulmonary vascular hemodynamic response to exercise in cardiopulmonary diseases. Circulation 2013;128:1470-1479.
10. Muller-Mottet S, Hildenbrand FF, Keusch S, Hasler E, Maggiorini M, Speich R, Bloch KE, Ulrich S. Effects of exercise and vasodilators on cerebral tissue oxygenation in pulmonary hypertension. Lung 2015;193:113-120.
11. Kim NH, Delcroix M, Jenkins DP, Channick R, Dartevelle P, Jansa P, Lang I, Madani MM, Ogino H, Pengo V, Mayer E. Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol 2013;62:D92-D99.
12. Muller-Mottet S, Hasler E, Opitz I, Weder W, Schuepbach R, Speich R, Ulrich S. Chronic thromboembolic pulmonary hypertension. Cardiovasc Med 2014;17: 328-333.
13. Grunig E, Lichtblau M, Ehlken N, Ghofrani HA, Reichenberger F, Staehler G, Halank M, Fischer C, Seyfarth HJ, Klose H, Meyer A, Sorichter S, Wilkens H, Rosenkranz S, Opitz C, Leuchte H, Karger G, Speich R, Nagel C. Safety and efficacy of exercise training in various forms of pulmonary hypertension. Eur Respir J 2012;40:84-92.
14. Ehlken N, Lichtblau M, Klose H, Weidenhammer J, Fischer C, Nechwatal R, Uiker S, Halank M, Olsson K, Seeger W, Gall H, Rosenkranz S, Wilkens H, Mertens D, Seyfarth HJ, Opitz C, Ulrich S, Egenlauf B, Grunig E. Exercise training improves peak oxygen consumption and haemodynamics in patients with severe pulmonary arterial hypertension and inoperable chronic thrombo-embolic pulmonary hypertension: a prospective, randomized, controlled trial. Eur Heart J 2016;37:35-44.
15. Ulrich S, Keusch S, Hildenbrand FF, Lo Cascio C, Huber LC, Tanner FC, Speich R, Bloch KE. Effect of nocturnal oxygen and acetazolamide on exercise performance in patients with pre-capillary pulmonary hypertension and sleep-disturbed breathing: randomized, double-blind, cross-over trial. Eur Heart J 2015;36:615-623.
16. ATS. ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 2003;167:211-277.
17. Subudhi AW,Dimmen AC, Roach RC. Effects of acute hypoxia on cerebral andmuscle oxygenation during incremental exercise. J Appl Physiol (1985) 2007;103:177-183.
18. Ulrich S, Nussbaumer-Ochsner Y, Vasic I, Hasler E, Latshang TD, Kohler M, Muehlemann T, Wolf M, Bloch KE. Cerebral oxygenation in patients with OSA: effects of hypoxia at altitude and impact of acetazolamide. Chest 2014;146:299-308.
19. Muller-Mottet S, Hildenbrand FF, Keusch S, Hasler E, Maggiorini M, Speich R, Bloch KE, Ulrich S. Effects of exercise and vasodilators on cerebral tissue oxygenation in pulmonary hypertension. Lung 2015;193:113-120.
20. Ferreira EV, Ota-Arakaki JS, Ramos RP, Barbosa PB, Almeida M, Treptow EC, Valois FM, Nery LE, Neder JA. Optimizing the evaluation of excess exercise ventilation for prognosis assessment in pulmonary arterial hypertension. Eur J Prev Cardiol 2014;21:1409-1419.
21. Naeije R, van de Borne P. Clinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension. Eur Respir J 2009;34:792-794.
22. Glaser S, Ittermann T, Schaper C, Obst A, Dorr M, Spielhagen T, Felix SB, Volzke H, Bollmann T, Opitz CF, Warnke C, Koch B, Ewert R. The Study of Health in Pomerania (SHIP) reference values for cardiopulmonary exercise testing. Pneumologie 2013;67:58-63.
23. Bingisser R, Kaplan V, Scherer T, Russi EW, Bloch KE. Effect of training on repeatability of cardiopulmonary exercise performance in normal men and women. Med Sci Sports Exerc 1997;29:1499-1504.
24. Kazis LE, Anderson JJ, Meenan RF. Effect sizes for interpreting changes in health status. Med Care 1989;27:S178-S189.
25. Ulrich SH, Hasler ED, Muller-Mottet S, Keusch S, Furian M, Latshang TD, Schneider S, Saxer S, Bloch KE. Mechanisms of improved exercise performance under hyperoxia. Respiration 2017;93:90-98.
26. Melot C, Naeije R. Pulmonary vascular diseases. Compr Physiol 2011;1:593-619.
27. Sun XG, Hansen JE, Oudiz RJ, Wasserman K. Gas exchange detection of exercise-induced right-to-left shunt in patients with primary pulmonary hypertension. Circulation 2002;105:54-60.
28. Dempsey JA, Smith CA. Pathophysiology of human ventilatory control. Eur Respir J 2014;44:495-512.
29. Siebenmann C, Lundby C. Regulation of cardiac output in hypoxia. Scand J Med Sci Sports 2015;25:53-59.