Optimizing the evaluation of excess exercise ventilation for prognosis assessment in pulmonary arterial hypertension

European Journal of Preventive Cardiology

Volumn 21, Issue 11, 2014, Pages 1409-1419

  Ferreira, Eloara V M ^a   Ota Arakaki, Jaquelina S ^a   Ramos, Roberta P ^a   Barbosa, Priscila B ^a   Almeida, Melline ^a   Treptow, Erika C ^a   Valois, Fabricio M ^a   Nery, Luiz E ^a   Neder, J Alberto ^a,b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

exercise testing; Exertion; prognosis; pulmonary hypertension; ventilation

Indexed keywords

CARBON DIOXIDE;

ADULT; ANAEROBIC THRESHOLD; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; EXERCISE TEST; FEMALE; FOLLOW UP; HEART FAILURE; HUMAN; KAPLAN MEIER METHOD; LUNG VENTILATION; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OXYGEN CONSUMPTION; PROGNOSIS; PULMONARY HYPERTENSION; REGRESSION ANALYSIS; TERTIARY HEALTH CARE; TREATMENT OUTCOME; ARTERIAL PRESSURE; BRAZIL; CHI SQUARE DISTRIBUTION; CROSS-SECTIONAL STUDY; DISEASE COURSE; DISEASE FREE SURVIVAL; HYPERTENSION, PULMONARY; LUNG; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; PULMONARY ARTERY; RISK FACTOR; SPIROMETRY; TERTIARY CARE CENTER; TIME; YOUNG ADULT;

ADULT; ARTERIAL PRESSURE; BRAZIL; CHI-SQUARE DISTRIBUTION; CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; EXERCISE TEST; FEMALE; HUMANS; HYPERTENSION, PULMONARY; KAPLAN-MEIER ESTIMATE; LUNG; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PULMONARY ARTERY; PULMONARY VENTILATION; RISK FACTORS; SPIROMETRY; TERTIARY CARE CENTERS; TIME FACTORS; YOUNG ADULT;

EID: 84899874134     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1177/2047487313494293     Document Type: Article

References (42)

1. Ferrazza AM, Martolini D, Valli G, et al. Cardiopulmonary exercise testing in the functional and prognostic evaluation of patients with pulmonary diseases. Respiration. 2009 ; 77: 3-17
2. Arena R, Lavie CJ, Milani RV, et al. Cardiopulmonary exercise testing in patients with pulmonary arterial hypertension: An evidence-based review. J Heart Lung Transplant. 2010 ; 29: 159-173
3. Wensel R, Opitz C, Anker S, et al. Assessment of survival in patients with primary pulmonary hypertension. Importance of cardiopulmonary exercise testing. Circulation. 2002 ; 106: 319-324
4. Groepenhoff H, Vonk-Noordegraaf A, Boonstra A, et al. Exercise testing to estimate survival in pulmonary hypertension. Med Sci Sports Exerc. 2008 ; 40: 1725-1732
5. Oudiz RJ, Midde R, Hovenesyan A, et al. Usefulness of right-to-left shunting and poor exercise gas exchange for predicting prognosis in patients with pulmonary arterial hypertension. Am J Cardiol. 2010 ; 105: 1186-1191
6. Schwaiblmair M, Faul C, von Scheidt W, et al. Ventilatory efficiency testing as prognostic value in patients with pulmonary hypertension. BMC Pulm Med. 2012 ; 7: 12-23
7. Deboeck G, Niset G, Lamotte M, et al. Cardiopulmonary exercise testing in pulmonary arterial hypertension and in congestive heart failure. Eur Respir J. 2004 ; 23: 747-751
8. Wensel R, Francis DP, Meyer FJ, et al. Incremental prognostic value of cardiopulmonary exercise testing and resting haemodynamics in pulmonary arterial hypertension. Int J Cardiol. Epub ahead of print 9 April 2012. DOI:10.1016/j.ijcard.2012.03.135.
9. Chua TP, Ponikowski P, Harrington D, et al. Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol. 1997 ; 29: 1585-1590
10. Arena R, Myers J, Aslam SS, et al. Peak VO2 and VE/VCO2 slope in patients with heart failure: A prognostic comparison. Am Heart J. 2004 ; 147: 354-360
11. Methvin AB, Owens AT, Emmi AG, et al. Ventilatory inefficiency reflects right ventricular dysfunction in systolic heart failure. Chest. 2011 ; 139: 617-625
12. Habedank D, Reindl I, Vietzke G, et al. Ventilatory efficiency and exercise tolerance in 101 healthy volunteers. Eur J Appl Physiol. 1998 ; 77: 421-426
13. Neder JA, Nery LE, Peres C, et al. Reference values for dynamic responses to incremental cycle ergometry in males and females aged 20 to 80. Am J Respir Crit Care Med. 2001 ; 164: 1481-1486
14. Sun XG, Hansen JE, Garatachea N, et al. Ventilatory efficiency during exercise in healthy subjects. Am J Respir Crit Care Med. 2002 ; 166: 1443-1448
15. Wensel R, Opitz CF, Ewert R, et al. Effects of iloprost inhalation on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension. Circulation. 2000 ; 101: 2388-2392
16. Oudiz RJ, Roveran G, Hansen JE, et al. Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension. Eur J Heart Fail. 2007 ; 9: 917-921
17. Deboeck G, Niset G, Lamotte M, et al. Exercise testing in pulmonary arterial hypertension and in chronic heart failure. Eur Respir J. 2004 ; 23: 747-751
18. Tabet JY, Beauvais F, Thabut G, et al. A critical appraisal of the prognostic value of the VE/VCO2 slope in chronic heart failure. Eur J Cardiovasc Prev Rehabil. 2003 ; 10: 267-272
19. Arena R, Humphrey R, Peberdy MA. Prognostic ability of VE/VCO2 slope calculations using different exercise test time intervals in subjects with heart failure. Eur J Cardiovasc Prev Rehabil. 2003 ; 10: 463-468
20. Ingle L, Goode K, Carroll S, et al. Prognostic value of the VE/VCO2 slope calculated from different time intervals in patients with suspected heart failure. Int J Cardiol. 2007 ; 118: 350-355
21. Sun XG, Hansen JE, Oudiz RJ, et al. Exercise pathophysiology in patients with primary pulmonary hypertension. Circulation. 2001 ; 104: 429-435
22. Sun XG, Hansen JE, Oudiz RJ, et al. Gas exchange detection of exercise-induced right-to-left shunt in patients with primary pulmonary hypertension. Circulation. 2002 ; 105: 54-60
23. Sue DY. Excess ventilation during exercise and prognosis in chronic heart failure. Am J Respir Crit Care Med. 2011 ; 183: 1302-1310
24. Paolillo S, Farina S, Bussotti M, et al. Exercise testing in the clinical management of patients affected by pulmonary arterial hypertension. Eur J Cardiovasc Prev Rehabil. 2012 ; 19: 960-971
25. Guazzi M, De Vita S, Cardano P, et al. Normalization for peak oxygen uptake increases the prognostic power of the ventilatory response to exercise in patients with chronic heart failure. Am Heart J. 2003 ; 146: 542-548
26. Toste A, Soares RM, Feliciano J, et al. Combining ventilatory efficiency and peak oxygen consumption in the prognostic assessment of patients with chronic heart failure. Rev Port Cardiol. 2010 ; 29: 1305-1320
27. Galiè N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Task Force for Diagnosis and Treatment of Pulmonary Hypertension of European Society of Cardiology (ESC); European Respiratory Society (ERS); International Society of Heart and Lung Transplantation (ISHLT). Eur Respir J. 2009 ; 34: 1219-1263
28. Guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002 ; 166: 111-117
29. Task Force ERS, Palange P, Ward SA, et al. Recommendations on the use of exercise testing in clinical practice. Eur Respir J. 2007 ; 29: 185-209
30. Neder JA, Nery LE, Castelo A, et al. Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry: A randomised study. Eur Respir J. 1999 ; 14: 1304-1313
31. Sue DY, Wasserman K, Moricca RB, et al. Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease. Use of the V-slope method for anaerobic threshold determination. Chest. 1988 ; 94: 931-938
32. Martinez FJ, Stanopoulos I, Acero R, et al. Graded comprehensive cardiopulmonary exercise testing in the evaluation of dyspnea unexplained by routine evaluation. Chest. 1994 ; 105: 168-174
33. Belardinelli R, Lacalaprice F, Carle F, et al. Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing. Eur Heart J. 2003 ; 24: 1304-1313
34. Solal AC, Chabernaud JM, Gourgon R. Comparison of oxygen uptake during bicycle exercise in patients with chronic heart failure and normal subjects. J Am Coll Cardiol. 1990 ; 16: 80-85
35. Bard RL, Gillespie BW, Clarke NS, et al. Determining the best ventilatory efficiency measure to predict mortality in patients with heart failure. J Heart Lung Transplant. 2006 ; 25: 589-595
36. Naeije R, Chesler N. Pulmonary circulation at exercise. Compar Physiol. 2012 ; 2: 711-741
37. Naeije R, van de Borne P. Clinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension. Eur Respir J. 2009 ; 34: 792-794
38. Olson TP, Joyner MJ, Johnson BD. Influence of locomotor muscle metaboreceptor stimulation on the ventilatory response to exercise in heart failure. Circ Heart Fail. 2010 ; 3: 212-219
39. Myers J, Arena R, Oliveira RB, et al. The lowest VE/VCO2 ratio during exercise as a predictor of outcomes in patients with heart failure. J Card Fail. 2009 ; 15: 756-762
40. Jaussaud J, Douard H. Usefulness of the lowest VE/VCO2 ratio measured during exercise in heart failure. Eur J Heart Fail. 2011 ; 13: 809-817
41. Zhai Z, Murphy K, Tighe H, et al. Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Chest. 2011 ; 140: 1284-1291
42. Valli G, Vizza CD, Onorati P, et al. Pathophysiological adaptations to walking and cycling in primary pulmonary hypertension. Eur J Appl Physiol. 2008 ; 102: 417-424