Effects of Exercise and Vasodilators on Cerebral Tissue Oxygenation in Pulmonary Hypertension

Lung

Volumn 193, Issue 1, 2015, Pages 113-120

  Müller Mottet, Séverine ^a   Hildenbrand, Florian F ^a   Keusch, Stephan ^a   Hasler, Elisabeth ^a   Maggiorini, Marco ^a   Speich, Rudolf ^a   Bloch, Konrad E ^a,b   Ulrich, Silvia ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cerebral tissue oxygenation; Exercise; Pulmonary hypertension

Indexed keywords

NITROGEN OXIDE; OXYGEN; VASODILATOR AGENT; ANTIHYPERTENSIVE AGENT; NITRIC OXIDE;

ADULT; AGED; ARTICLE; BICYCLE; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE; EXERCISE TOLERANCE; FEMALE; HEART CATHETERIZATION; HUMAN; INHALATION; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MALE; MEAN ARTERIAL PRESSURE; OXYGEN SATURATION; PREDICTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REST; THROMBOEMBOLISM; TISSUE OXYGENATION; VENOUS OXYGEN TENSION; WALKING; WORKLOAD; BLOOD; BRAIN; BRAIN CIRCULATION; DRUG EFFECTS; EXERCISE TEST; HYPERTENSION, PULMONARY; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEAR INFRARED SPECTROSCOPY; OXYGEN CONSUMPTION; OXYGEN THERAPY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; RANDOMIZED CONTROLLED TRIAL; SWITZERLAND; TIME; TREATMENT OUTCOME; VASCULARIZATION;

ADMINISTRATION, INHALATION; AGED; ANTIHYPERTENSIVE AGENTS; BRAIN; CARDIAC CATHETERIZATION; CEREBROVASCULAR CIRCULATION; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NITRIC OXIDE; OXYGEN; OXYGEN CONSUMPTION; OXYGEN INHALATION THERAPY; PREDICTIVE VALUE OF TESTS; SPECTROSCOPY, NEAR-INFRARED; SWITZERLAND; TIME FACTORS; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 84938060204     PISSN: 03412040     EISSN: 14321750     Source Type: Journal    
DOI: 10.1007/s00408-014-9667-5     Document Type: Article

References (23)

1. Galie N, Hoeper MM, Humbert M et al (2009) Guidelines for the diagnosis and treatment of pulmonary hypertension. The task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Respir J 34:1219–1263
2. Simonneau G, Robbins IM, Beghetti M et al (2009) Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 54(1):S43–S54
3. Manier G, Castaing Y (1994) Contribution of multiple inert gas elimination technique to pulmonary medicine–4. Gas exchange abnormalities in pulmonary vascular and cardiac disease. Thorax 49(11):1169–1174
4. Barbosa PB, Ferreira EM, Arakaki JS et al (2011) Kinetics of skeletal muscle O2 delivery and utilization at the onset of heavy-intensity exercise in pulmonary arterial hypertension. Eur J Appl Physiol 111(8):1851–1861
5. Rooks CR, Thom NJ, McCully KK et al (2010) Effects of incremental exercise on cerebral oxygenation measured by near-infrared spectroscopy: a systematic review. Prog Neurobiol 92(2):134–150
6. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories (2002) ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 166(1):111–117
7. Moinard J, Manier G, Pillet O et al (1994) Effect of inhaled nitric oxide on hemodynamics and VA/Q inequalities in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 149(6):1482–1487
8. Hildenbrand FF, Bloch KE, Speich R et al (2012) Daytime measurements underestimate nocturnal oxygen desaturations in pulmonary arterial and chronic thromboembolic pulmonary hypertension. Respiration 84:477–484
9. Ulrich S, Fischler M, Speich R et al (2008) Sleep-related breathing disorders in patients with pulmonary hypertension. Chest 133(6):1375–1380
10. Sun XG, Hansen JE, Oudiz RJ et al (2001) Exercise pathophysiology in patients with primary pulmonary hypertension. Circulation 104(4):429–435
11. Matsuura C, Gomes PS, Haykowsky M et al (2011) Cerebral and muscle oxygenation changes during static and dynamic knee extensions to voluntary fatigue in healthy men and women: a near infrared spectroscopy study. Clin Physiol Funct Imaging 31(2):114–123
12. Secher NH, Seifert T, Van Lieshout JJ (2008) Cerebral blood flow and metabolism during exercise: implications for fatigue. J Appl Physiol 104(1):306–314
13. Bhambhani Y, Malik R, Mookerjee S (2007) Cerebral oxygenation declines at exercise intensities above the respiratory compensation threshold. Respir Physiol Neurobiol 156(2):196–202
14. Marshall HC, Hamlin MJ, Hellemans J et al (2008) Effects of intermittent hypoxia on SaO(2), cerebral and muscle oxygenation during maximal exercise in athletes with exercise-induced hypoxemia. Eur J Appl Physiol 104(2):383–393
15. Jensen G, Nielsen HB, Ide K et al (2002) Cerebral oxygenation during exercise in patients with terminal lung disease. Chest 122(2):445–450
16. Noakes TD, Peltonen JE, Rusko HK (2001) Evidence that a central governor regulates exercise performance during acute hypoxia and hyperoxia. J Exp Biol 204(Pt 18):3225–3234
17. Vermeij A, van Beek AH, Olde Rikkert MG et al (2012) Effects of aging on cerebral oxygenation during working-memory performance: a functional near-infrared spectroscopy study. PLoS One 7(9):e46210
18. Oussaidene K, Prieur F, Bougault V et al (2013) Cerebral oxygenation during hyperoxia-induced increase in exercise tolerance for untrained men. Eur J Appl Physiol 113(8):2047–2056
19. Kayser B, Narici M, Binzoni T et al (1994) Fatigue and exhaustion in chronic hypobaric hypoxia: influence of exercising muscle mass. J Appl Physiol (1985) 76(2):634–640
20. Jones AM, Burnley M (2009) Oxygen uptake kinetics: an underappreciated determinant of exercise performance. Int J Sports Physiol Perform 4(4):524–532
21. Naeije R (2005) Breathing more with weaker respiratory muscles in pulmonary arterial hypertension. Eur Respir J 25(1):6–8
22. Noponen T, Nordh A, Berg A et al (2009) Circulatory effects of inhaled iloprost in the newborn preterm lamb. Pediatr Res 66(4):416–422
23. Nagdyman N, Fleck T, Bitterling B et al (2006) Influence of intravenous sildenafil on cerebral oxygenation measured by near-infrared spectroscopy in infants after cardiac surgery. Pediatr Res 59(3):462–465