Hijacked evidence-based medicine: stay the course and throw the pirates overboard

Journal of Clinical Epidemiology

Volumn 84, Issue , 2017, Pages 11-13

  Ioannidis, John P A ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Evidence based medicine

Indexed keywords

ARTICLE; EVIDENCE BASED MEDICINE; MEDICAL CARE; MEDICAL RESEARCH; PRIORITY JOURNAL; HUMAN; METHODOLOGY;

BIOMEDICAL RESEARCH; EVIDENCE-BASED MEDICINE; HUMANS; RESEARCH DESIGN;

EID: 85019377338     PISSN: 08954356     EISSN: 18785921     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2017.02.001     Document Type: Article

References (20)

1. Ioannidis, J.P., Evidence-based medicine has been hijacked: a report to David Sackett. J Clin Epidemiol 73 (2016), 82–86.
2. Fava, G.A., Evidence-based medicine was bound to fail: a report to Alvan Feinstein. J Clin Epidemiol 84 (2017), 3–7.
3. Engel, G.L., Physician scientists and scientific physicians. Am J Med 82 (1987), 107–111.
4. Feinstein, A.R., Horwitz, R.I., Problems in the “evidence” of “evidence-based medicine”. Am J Med 103 (1997), 529–535.
5. Sackett, D.L., Rosenberg, W.M., Gray, J.A., Haynes, R.B., Richardson, W.S., Evidence based medicine: what it is and what it isn't. BMJ 312 (1996), 71–72.
6. Ioannidis, J.P., Adverse events in randomized trials: neglected, restricted, distorted, and silenced. Arch Intern Med 169 (2009), 1737–1739.
7. Golder, S., Loke, Y.K., Wright, K., Norman, G., Reporting of adverse events in published and unpublished studies of health care interventions: a systematic review. PLoS Med, 13(9), 2016, e1002127.
8. Assmann, S.F., Pocock, S.J., Enos, L.E., Kasten, L.E., Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet 355 (2000), 1064–1069.
9. Kasenda, B., Schandelmaier, S., Sun, X., von Elm, E., You, J., Blumle, A., et al. Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications. BMJ, 349, 2014, g4539.
10. Sun, X., Briel, M., Busse, J.W., You, J.J., Akl, E.A., Mejza, F., et al. Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ, 344, 2012, e1553.
11. Joyner, M.J., Paneth, N., Seven questions for personalized medicine. JAMA 314 (2015), 999–1000.
12. Joyner, M.J., Paneth, N., Ioannidis, J.P., What happens when underperforming big ideas in research Become Entrenched?. JAMA 316 (2016), 1355–1356.
13. Manrai, A.K., Ioannidis, J.P., Kohane, I.S., Clinical genomics: from pathogenicity claims to quantitative risk estimates. JAMA 315 (2016), 1233–1234.
14. Yavchitz, A., Ravaud, P., Altman, D.G., Moher, D., Hrobjartsson, A., Lasserson, T., et al. A new classification of spin in systematic reviews and meta-analyses was developed and ranked according to the severity. J Clin Epidemiol 75 (2016), 56–65.
15. Ebrahim, S., Bance, S., Athale, A., Malachowski, C., Ioannidis, J.P., Meta-analyses with industry involvement are massively published and report no caveats for antidepressants. J Clin Epidemiol 70 (2016), 155–163.
16. Gøtzsche, P.C., Ioannidis, J.P., Content area experts as authors: helpful or harmful for systematic reviews and meta-analyses?. BMJ, 345, 2012, e7031.
17. Patsopoulos, N.A., Analatos, A.A., Ioannidis, J.P., Relative citation impact of various study designs in the health sciences. JAMA 293 (2005), 2362–2366.
18. Ioannidis, J.P., Why most clinical research is not useful. PLoS Med, 13(6), 2016, e1002049.
19. Greenhalgh, T., Howick, J., Maskrey, N., Evidence Based Medicine Renaissance Group. Evidence based medicine: a movement in crisis?. BMJ, 348, 2014, g3725.
20. Greenhalgh, T., Why do we always end up here? Evidence-based medicine's conceptual cul-de-sacs and some off-road alternative routes. J Prim Health Care 4 (2012), 92–97.