What happens when underperforming big ideas in research become entrenched?

JAMA - Journal of the American Medical Association

Volumn 316, Issue 13, 2016, Pages 1355-1356

  Joyner, Michael J ^a   Paneth, Nigel ^b   Ioannidis, John P A ^c  

^a MAYO CLINIC   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DECISION MAKING; ELECTRONIC HEALTH RECORD; FUNDING; HEALTH CARE QUALITY; HUMAN; INVESTMENT; MEDICAL RESEARCH; NOTE; PERSONALIZED MEDICINE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PUBLIC HEALTH; SCIENTIST; DISEASES; ECONOMICS; FINANCIAL MANAGEMENT; GENE THERAPY; GENETIC VARIATION; GENETICS; MEDLINE; MOLECULARLY TARGETED THERAPY; NATIONAL HEALTH ORGANIZATION; NEOPLASMS; PUBLISHING; STANDARDS; STATISTICS AND NUMERICAL DATA; STEM CELL TRANSPLANTATION; TRENDS; UNITED STATES;

BIOMEDICAL RESEARCH; DISEASE; ELECTRONIC HEALTH RECORDS; GENETIC THERAPY; GENETIC VARIATION; HUMANS; MOLECULAR TARGETED THERAPY; NATIONAL INSTITUTES OF HEALTH (U.S.); NEOPLASMS; PRECISION MEDICINE; PUBLISHING; PUBMED; RESEARCH SUPPORT AS TOPIC; STEM CELL TRANSPLANTATION; UNITED STATES;

EID: 84995791098     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2016.11076     Document Type: Note

References (8)

1. National Institutes of Health. Estimates of funding for various research, condition, and disease categories. https://report.nih.gov/categorical -spending.aspx. Accessed July 21, 2016.
2. Collins FS. Shattuck lecture-medical and societal consequences of the Human Genome Project. N Engl J Med. 1999;341(1):28-37.
3. Joyner MJ, Paneth N. Seven questions for personalized medicine. JAMA. 2015;314(10):999-1000.
4. Centers for Medicare & Medicaid Services. Data and program reports. https://www.cms.gov/regulations-and-guidance/legislation/ehrincentiveprograms/dataandreports.html. Accessed July 22, 2016.
5. Le Tourneau C, Delord JP, Gonçalves A, et al. Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA). Lancet Oncol. 2015;16 (13):1324-1334.
6. National Institutes of Health. NCI-Molecular Analysis for Therapy Choice (NCI-MATCH) trial. http://www.cancer.gov/about-cancer/treatment/clinical-trials/nci-supported/nci-match. Accessed July 22, 2016.
7. Nowbar AN, Mielewczik M, Karavassilis M, et al. Discrepancies in autologous bone marrow stem cell trials and enhancement of ejection fraction (DAMASCENE). BMJ. 2014;348:g2688.
8. ISSCR releases updated guidelines for stem cell research and clinical translation [press release]. Skokie, IL: International Society for Stem Cell Research; May 12, 2016.