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Volumn 7, Issue 27, 2016, Pages 40939-40952

The PI3K-AKT-mTOR pathway activates recovery from general anesthesia

Author keywords

General anesthesia; Morris water maze; Pathology Section; PI3K AKT mTOR pathway; Recovery from general anesthesia; Righting reflex

Indexed keywords

KETAMINE; MTOR PROTEIN, RAT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S6 KINASE; TARGET OF RAPAMYCIN KINASE;

EID: 85019188781     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10172     Document Type: Article
Times cited : (12)

References (48)
  • 1
    • 80355148374 scopus 로고    scopus 로고
    • Cognitive and behavioral outcomes after early exposure to anesthesia and surgery
    • Flick RP, Katusic SK, Colligan RC, Wilder RT, Voigt RG, Olson MD, et al. Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics 2011;128:e1053-61.
    • (2011) Pediatrics , vol.128 , pp. e1053-e1061
    • Flick, RP1    Katusic, SK2    Colligan, RC3    Wilder, RT4    Voigt, RG5    Olson, MD6
  • 2
    • 78650873111 scopus 로고    scopus 로고
    • General anesthesia, sleep, and coma
    • Brown EN, Lydic R, Schiff ND. General anesthesia, sleep, and coma. N Engl J Med 2010;363:2638-50.
    • (2010) N Engl J Med , vol.363 , pp. 2638-2650
    • Brown, EN1    Lydic, R2    Schiff, ND.3
  • 3
    • 79952130484 scopus 로고    scopus 로고
    • Functional connectivity in the brain: Effects of anesthesia
    • Nallasamy N, Tsao DY. Functional connectivity in the brain: Effects of anesthesia. Neuroscientist 2011;17:94-106.
    • (2011) Neuroscientist , vol.17 , pp. 94-106
    • Nallasamy, N1    Tsao, DY.2
  • 4
    • 77956342625 scopus 로고    scopus 로고
    • Anesthesia complications during scheduled cesarean delivery for morbidly obese women
    • 5
    • Vricella LK, Louis JM, Mercer BM, Bolden N. Anesthesia complications during scheduled cesarean delivery for morbidly obese women. Am J Obstet Gynecol 2010;203:276 e1-5.
    • (2010) Am J Obstet Gynecol , vol.203 , pp. 276e1
    • Vricella, LK1    Louis, JM2    Mercer, BM3    Bolden, N.4
  • 5
    • 79955474596 scopus 로고    scopus 로고
    • Postoperative cognitive dysfunction is independent of type of surgery and anesthetic
    • Evered L, Scott DA, Silbert B, Maruff P. Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth Analg 2011;112:1179-85.
    • (2011) Anesth Analg , vol.112 , pp. 1179-1185
    • Evered, L1    Scott, DA2    Silbert, B3    Maruff, P.4
  • 6
    • 55849108126 scopus 로고    scopus 로고
    • Consciousness and anesthesia
    • Alkire MT, Hudetz AG, Tononi G. Consciousness and anesthesia. Science 2008;322:876-80.
    • (2008) Science , vol.322 , pp. 876-880
    • Alkire, MT1    Hudetz, AG2    Tononi, G.3
  • 7
    • 77955262711 scopus 로고    scopus 로고
    • New insights into the pathophysiology of postoperative cognitive dysfunction
    • Krenk L, Rasmussen LS, Kehlet H. New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiol Scand 2010;54:951-6.
    • (2010) Acta Anaesthesiol Scand , vol.54 , pp. 951-956
    • Krenk, L1    Rasmussen, LS2    Kehlet, H.3
  • 8
    • 78650786676 scopus 로고    scopus 로고
    • Anesthesia-related maternal mortality in the united states: 1979-2002
    • Hawkins JL, Chang J, Palmer SK, Gibbs CP, Callaghan WM. Anesthesia-related maternal mortality in the united states: 1979-2002. Obstet Gynecol 2011;117:69-74.
    • (2011) Obstet Gynecol , vol.117 , pp. 69-74
    • Hawkins, JL1    Chang, J2    Palmer, SK3    Gibbs, CP4    Callaghan, WM.5
  • 9
    • 65349172340 scopus 로고    scopus 로고
    • Epidemiology of anesthesia-related mortality in the united states, 1999-2005
    • Li G, Warner M, Lang BH, Huang L, Sun LS. Epidemiology of anesthesia-related mortality in the united states, 1999-2005. Anesthesiology 2009;110:759-65.
    • (2009) Anesthesiology , vol.110 , pp. 759-765
    • Li, G1    Warner, M2    Lang, BH3    Huang, L4    Sun, LS.5
  • 10
    • 84901008792 scopus 로고    scopus 로고
    • Targeting pi3k/AKT/mtor signaling in cancer
    • Porta C, Paglino C, Mosca A. Targeting pi3k/AKT/mtor signaling in cancer. Front Oncol 2014;4:64.
    • (2014) Front Oncol , vol.4 , pp. 64
    • Porta, C1    Paglino, C2    Mosca, A.3
  • 11
    • 77952311165 scopus 로고    scopus 로고
    • Novel expression patterns of pi3k/AKT/ mtor signaling pathway components in colorectal cancer
    • 76-8
    • Johnson SM, Gulhati P, Rampy BA, Han Y, Rychahou PG, Doan HQ, et al. Novel expression patterns of pi3k/AKT/ mtor signaling pathway components in colorectal cancer. J Am Coll Surg 2010;210:767-76, 76-8.
    • (2010) J Am Coll Surg , vol.210 , pp. 767-776
    • Johnson, SM1    Gulhati, P2    Rampy, BA3    Han, Y4    Rychahou, PG5    Doan, HQ6
  • 12
    • 84937965830 scopus 로고    scopus 로고
    • Pi3king the lock: Targeting the pi3k/AKT/mtor pathway as a novel therapeutic strategy in neuroblastoma
    • King D, Yeomanson D, Bryant HE. Pi3king the lock: Targeting the pi3k/AKT/mtor pathway as a novel therapeutic strategy in neuroblastoma. J Pediatr Hematol Oncol 2015;37:245-51.
    • (2015) J Pediatr Hematol Oncol , vol.37 , pp. 245-251
    • King, D1    Yeomanson, D2    Bryant, HE.3
  • 13
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the pi3k/AKT/mtor pathway: Effective combinations and clinical considerations
    • LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA. Targeting the pi3k/AKT/mtor pathway: Effective combinations and clinical considerations. Drug Resist Updat 2008;11:32-50.
    • (2008) Drug Resist Updat , vol.11 , pp. 32-50
    • LoPiccolo, J1    Blumenthal, GM2    Bernstein, WB3    Dennis, PA.4
  • 14
    • 84983168903 scopus 로고    scopus 로고
    • Targeting pi3k/AKT/mtor signaling pathway in the treatment of prostate cancer radioresistance
    • Chang L, Graham PH, Ni J, Hao J, Bucci J, Cozzi PJ, et al. Targeting pi3k/AKT/mtor signaling pathway in the treatment of prostate cancer radioresistance. Crit Rev Oncol Hematol 2015;96:507-17.
    • (2015) Crit Rev Oncol Hematol , vol.96 , pp. 507-517
    • Chang, L1    Graham, PH2    Ni, J3    Hao, J4    Bucci, J5    Cozzi, PJ6
  • 16
    • 79957983577 scopus 로고    scopus 로고
    • Targeting the pi3k/AKT/mtor pathway-beyond rapalogs
    • Markman B, Dienstmann R, Tabernero J. Targeting the pi3k/AKT/mtor pathway-beyond rapalogs. Oncotarget 2010;1:530-43. doi: 10.18632/oncotarget.188.
    • (2010) Oncotarget , vol.1 , pp. 530-543
    • Markman, B1    Dienstmann, R2    Tabernero, J.3
  • 17
    • 38149062059 scopus 로고    scopus 로고
    • Role of mtor in physiology and pathology of the nervous system
    • Swiech L, Perycz M, Malik A, Jaworski J. Role of mtor in physiology and pathology of the nervous system. Biochim Biophys Acta 2008;1784:116-32.
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 116-132
    • Swiech, L1    Perycz, M2    Malik, A3    Jaworski, J.4
  • 18
    • 80051982748 scopus 로고    scopus 로고
    • Critical role of pi3k/AKT/gsk3beta in motoneuron specification from human neural stem cells in response to fgf2 and egf
    • Ojeda L, Gao J, Hooten KG, Wang E, Thonhoff JR, Dunn TJ, et al. Critical role of pi3k/AKT/gsk3beta in motoneuron specification from human neural stem cells in response to fgf2 and egf. PLoS One 2011;6:e23414.
    • (2011) PLoS One , vol.6 , pp. e23414
    • Ojeda, L1    Gao, J2    Hooten, KG3    Wang, E4    Thonhoff, JR5    Dunn, TJ6
  • 19
    • 34547793039 scopus 로고    scopus 로고
    • Pi3k/AKT and creb regulate adult neural hippocampal progenitor proliferation and differentiation
    • Peltier J, O'Neill A, Schaffer DV. Pi3k/AKT and creb regulate adult neural hippocampal progenitor proliferation and differentiation. Dev Neurobiol 2007;67:1348-61.
    • (2007) Dev Neurobiol , vol.67 , pp. 1348-1361
    • Peltier, J1    O'Neill, A2    Schaffer, DV.3
  • 20
    • 75749114797 scopus 로고    scopus 로고
    • Mtor signaling: At the crossroads of plasticity, memory and disease
    • Hoeffer CA, Klann E. Mtor signaling: At the crossroads of plasticity, memory and disease. Trends Neurosci 2010;33:67-75.
    • (2010) Trends Neurosci , vol.33 , pp. 67-75
    • Hoeffer, CA1    Klann, E.2
  • 21
    • 3242724040 scopus 로고    scopus 로고
    • Activation of the phosphoinositide 3-kinase-AKT-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
    • Hou L, Klann E. Activation of the phosphoinositide 3-kinase-AKT-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J Neurosci 2004;24:6352-61.
    • (2004) J Neurosci , vol.24 , pp. 6352-6361
    • Hou, L1    Klann, E.2
  • 23
    • 4544272020 scopus 로고    scopus 로고
    • Chronobiological study of the pharmacological response of rats to combination ketamine-midazolam
    • Rebuelto M, Ambros L, Waxman S, Montoya L. Chronobiological study of the pharmacological response of rats to combination ketamine-midazolam. Chronobiol Int 2004;21 (4-5):591-600.
    • (2004) Chronobiol Int , vol.21 , Issue.4-5 , pp. 591-600
    • Rebuelto, M1    Ambros, L2    Waxman, S3    Montoya, L.4
  • 24
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: Procedures for assessing spatial and related forms of learning and memory
    • Vorhees CV, Williams MT. Morris water maze: Procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006;1:848-58.
    • (2006) Nat Protoc , vol.1 , pp. 848-858
    • Vorhees, CV1    Williams, MT.2
  • 25
    • 0033910789 scopus 로고    scopus 로고
    • Influences of pre- and postnatal nutritional exposures on vascular/endocrine systems in animals
    • Suppl 3
    • Hoet JJ, Ozanne S, Reusens B. Influences of pre- and postnatal nutritional exposures on vascular/endocrine systems in animals. Environ Health Perspect 2000;108 Suppl 3:563-8.
    • (2000) Environ Health Perspect , vol.108 , pp. 563-568
    • Hoet, JJ1    Ozanne, S2    Reusens, B.3
  • 27
    • 84859457602 scopus 로고    scopus 로고
    • Ngf promotes cell cycle progression by regulating d-type cyclins via pi3k/akt and mapk/erk activation in human corneal epithelial cells
    • Hong J, Qian T, Le Q, Sun X, Wu J, Chen J, et al. Ngf promotes cell cycle progression by regulating d-type cyclins via pi3k/akt and mapk/erk activation in human corneal epithelial cells. Mol Vis 2012;18:758-64.
    • (2012) Mol Vis , vol.18 , pp. 758-764
    • Hong, J1    Qian, T2    Le, Q3    Sun, X4    Wu, J5    Chen, J6
  • 28
    • 84864663005 scopus 로고    scopus 로고
    • Activation of erk1/2 and pi3k/akt by igf-1 on gap-43 expression in drg neurons with excitotoxicity induced by glutamate in vitro
    • Liu Z, Cai H, Zhang P, Li H, Liu H, Li Z. Activation of erk1/2 and pi3k/akt by igf-1 on gap-43 expression in drg neurons with excitotoxicity induced by glutamate in vitro. Cell Mol Neurobiol 2012;32:191-200.
    • (2012) Cell Mol Neurobiol , vol.32 , pp. 191-200
    • Liu, Z1    Cai, H2    Zhang, P3    Li, H4    Liu, H5    Li, Z.6
  • 29
    • 0025178689 scopus 로고
    • Function of myocardial alpha-adrenoceptors
    • Benfey BG. Function of myocardial alpha-adrenoceptors. Life Sci 1990;46:743-57.
    • (1990) Life Sci , vol.46 , pp. 743-757
    • Benfey, BG.1
  • 30
    • 0346724668 scopus 로고    scopus 로고
    • Mechanism of action of volatile anesthetics: Role of protein kinase c
    • Gomez RS, Guatimosim C, Gomez MV. Mechanism of action of volatile anesthetics: Role of protein kinase c. Cell Mol Neurobiol 2003;23:877-85.
    • (2003) Cell Mol Neurobiol , vol.23 , pp. 877-885
    • Gomez, RS1    Guatimosim, C2    Gomez, MV.3
  • 31
    • 84858079914 scopus 로고    scopus 로고
    • Pi3k/AKT/mtor pathway in angiogenesis
    • Karar J, Maity A. Pi3k/AKT/mtor pathway in angiogenesis. Front Mol Neurosci 2011;4:51.
    • (2011) Front Mol Neurosci , vol.4 , pp. 51
    • Karar, J1    Maity, A.2
  • 32
    • 84883370400 scopus 로고    scopus 로고
    • Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the pi3k/AKT/mtor pathway
    • Chen A, Xiong LJ, Tong Y, Mao M. Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the pi3k/AKT/mtor pathway. Mol Med Rep 2013;8:1011-6.
    • (2013) Mol Med Rep , vol.8 , pp. 1011-1016
    • Chen, A1    Xiong, LJ2    Tong, Y3    Mao, M.4
  • 33
    • 11144335900 scopus 로고    scopus 로고
    • A new paradigm: Cross talk of protein kinases during reperfusion saves life!
    • Schulz R. A new paradigm: Cross talk of protein kinases during reperfusion saves life! Am J Physiol Heart Circ Physiol 2005;288:H1-2.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288 , pp. H1-H2
    • Schulz, R.1
  • 34
    • 84896401739 scopus 로고    scopus 로고
    • Molecular targets for cancer therapy in the pi3k/AKT/mtor pathway
    • Polivka J, Jr., Janku F. Molecular targets for cancer therapy in the pi3k/AKT/mtor pathway. Pharmacol Ther 2014;142:164-75.
    • (2014) Pharmacol Ther , vol.142 , pp. 164-175
    • Polivka, J1    Janku, F.2
  • 35
  • 36
    • 84878831559 scopus 로고    scopus 로고
    • Overcoming acquired resistance to anticancer therapy: Focus on the pi3k/AKT/mtor pathway
    • Burris HA, 3rd. Overcoming acquired resistance to anticancer therapy: Focus on the pi3k/AKT/mtor pathway. Cancer Chemother Pharmacol 2013;71:829-42.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 829-842
    • Burris, HA1
  • 37
    • 84879478480 scopus 로고    scopus 로고
    • Targeting the pi3k/AKT/mtor pathway in castration-resistant prostate cancer
    • Bitting RL, Armstrong AJ. Targeting the pi3k/AKT/mtor pathway in castration-resistant prostate cancer. Endocr Relat Cancer 2013;20:R83-99.
    • (2013) Endocr Relat Cancer , vol.20 , pp. R83-R99
    • Bitting, RL1    Armstrong, AJ.2
  • 38
    • 58749105333 scopus 로고    scopus 로고
    • Incidence and risk factors for perioperative hyperglycemia in children with traumatic brain injury
    • Sharma D, Jelacic J, Chennuri R, Chaiwat O, Chandler W, Vavilala MS. Incidence and risk factors for perioperative hyperglycemia in children with traumatic brain injury. Anesth Analg 2009;108:81-9.
    • (2009) Anesth Analg , vol.108 , pp. 81-89
    • Sharma, D1    Jelacic, J2    Chennuri, R3    Chaiwat, O4    Chandler, W5    Vavilala, MS.6
  • 39
    • 84896856648 scopus 로고    scopus 로고
    • Folic acid stimulation of neural stem cell proliferation is associated with altered methylation profile of pi3k/akt/creb
    • Yu M, Li W, Luo S, Zhang Y, Liu H, Gao Y, et al. Folic acid stimulation of neural stem cell proliferation is associated with altered methylation profile of pi3k/akt/creb. J Nutr Biochem 2014;25:496-502.
    • (2014) J Nutr Biochem , vol.25 , pp. 496-502
    • Yu, M1    Li, W2    Luo, S3    Zhang, Y4    Liu, H5    Gao, Y6
  • 40
    • 85101782937 scopus 로고    scopus 로고
    • S6k promotes dopaminergic neuronal differentiation through pi3k/akt/ mtor-dependent signaling pathways in human neural stem cells. Mol Neurobiol 2015 41 Feliciano DM, Zhang S, Nasrallah CM, Lisgo SN, Bordey A. Embryonic cerebrospinal fluid nanovesicles carry evolutionarily conserved molecules and promote neural stem cell amplification
    • Lee JE, Lim MS, Park JH, Park CH, Koh HC. S6k promotes dopaminergic neuronal differentiation through pi3k/akt/ mtor-dependent signaling pathways in human neural stem cells. Mol Neurobiol 2015 41 Feliciano DM, Zhang S, Nasrallah CM, Lisgo SN, Bordey A. Embryonic cerebrospinal fluid nanovesicles carry evolutionarily conserved molecules and promote neural stem cell amplification. PLoS One 2014;9:e88810.
    • (2014) PLoS One , vol.9 , pp. e88810
    • Lee, JE1    Lim, MS2    Park, JH3    Park, CH4    Koh, HC.5
  • 41
    • 77749340948 scopus 로고    scopus 로고
    • Keratinocyte growth factor promotes preadipocyte proliferation via an autocrine mechanism
    • Zhang T, Guan H, Yang K. Keratinocyte growth factor promotes preadipocyte proliferation via an autocrine mechanism. J Cell Biochem 2010;109:737-46.
    • (2010) J Cell Biochem , vol.109 , pp. 737-746
    • Zhang, T1    Guan, H2    Yang, K.3
  • 42
    • 62149136644 scopus 로고    scopus 로고
    • Anesthesia, calcium homeostasis and alzheimer's disease
    • Wei H, Xie Z. Anesthesia, calcium homeostasis and alzheimer's disease. Curr Alzheimer Res 2009;6:30-5.
    • (2009) Curr Alzheimer Res , vol.6 , pp. 30-35
    • Wei, H1    Xie, Z.2
  • 43
    • 84869217593 scopus 로고    scopus 로고
    • General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex
    • Thrane AS, Rangroo Thrane V, Zeppenfeld D, Lou N, Xu Q, Nagelhus EA, et al. General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. Proc Natl Acad Sci U S A 2012;109:18974-9.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 18974-18979
    • Thrane, AS1    Rangroo Thrane, V2    Zeppenfeld, D3    Lou, N4    Xu, Q5    Nagelhus, EA6
  • 45
    • 77649230770 scopus 로고    scopus 로고
    • contribution of functional neuroimaging studies to the understanding of the mechanisms of general anesthesia
    • Spe
    • Boveroux P, Bonhomme V, Kirsch M, Noirhomme Q, Ledoux D, Hans G, et al. [contribution of functional neuroimaging studies to the understanding of the mechanisms of general anesthesia]. Rev Med Liege 2009;64 Spec No:36-41.
    • (2009) Rev Med Liege , vol.64 , pp. 36-41
    • Boveroux, P1    Bonhomme, V2    Kirsch, M3    Noirhomme, Q4    Ledoux, D5    Hans, G6
  • 46
    • 78650873111 scopus 로고    scopus 로고
    • General anesthesia, sleep, and coma
    • Brown EN, Lydic R, Schiff ND. General anesthesia, sleep, and coma. N Engl J Med 2010;363:2638-50.
    • (2010) N Engl J Med , vol.363 , pp. 2638-2650
    • Brown, EN1    Lydic, R2    Schiff, ND.3
  • 47
    • 84948165767 scopus 로고    scopus 로고
    • Effects of anesthesia type on short-term postoperative cognitive function in obstetric patients following cesarean section
    • Altun C, Borazan H, Sahin O, Gezginc K. Effects of anesthesia type on short-term postoperative cognitive function in obstetric patients following cesarean section. J Turk Ger Gynecol Assoc 2015;16:219-25.
    • (2015) J Turk Ger Gynecol Assoc , vol.16 , pp. 219-225
    • Altun, C1    Borazan, H2    Sahin, O3    Gezginc, K.4
  • 48
    • 78650475179 scopus 로고    scopus 로고
    • The impact of general and regional anesthesia on the incidence of post-operative cognitive dysfunction and post-operative delirium: A systematic review with meta-analysis
    • Suppl 3
    • Mason SE, Noel-Storr A, Ritchie CW. The impact of general and regional anesthesia on the incidence of post-operative cognitive dysfunction and post-operative delirium: A systematic review with meta-analysis. J Alzheimers Dis 2010;22 Suppl 3:67-79.
    • (2010) J Alzheimers Dis , vol.22 , pp. 67-79
    • Mason, SE1    Noel-Storr, A2    Ritchie, CW.3


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