Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 19, 2017, Pages E3806-E3815

  Nakagawa, Hayato ^a   Suzuki, Nobumi ^a,b   Hirata, Yoshihiro ^a   Hikiba, Yohko ^b   Hayakawa, Yoku ^a   Kinoshita, Hiroto ^a   Ihara, Sozaburo ^a   Uchino, Koji ^a   Nishikawa, Yuji ^c   Ijichi, Hideaki ^a   Otsuka, Motoyuki ^a   Arita, Junichi ^a   Sakamoto, Yoshihiro ^a   Hasegawa, Kiyoshi ^a   Kokudo, Norihiro ^a   Tateishi, Keisuke ^a   Koike, Kazuhiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b INSTITUTE FOR ADULT DISEASES   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Amphiregulin; Extrahepatic cholangiocarcinoma; IL 33; ILC2; Organoid

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BILIRUBIN; BIRC5 PROTEIN; COMPLEMENTARY DNA; CYCLIN D1; INTERLEUKIN 13; INTERLEUKIN 33; INTERLEUKIN 5; K RAS PROTEIN; MESSENGER RNA; PROTEIN; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; UVOMORULIN; VERTEPORFIN; YAP PROTEIN; CADHERIN; E-CADHERIN PROTEIN, MOUSE; IL33 PROTEIN, MOUSE; KRAS2 PROTEIN, MOUSE; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT INJURY; BILIARY EPITHELIAL INJURY; BILIRUBIN BLOOD LEVEL; CANCER GROWTH; CARCINOGENESIS; CELL HYPERPLASIA; CELL INFILTRATION; CELL INVASION; CELL LINEAGE; CELL PROLIFERATION; CHOLANGIOCARCINOGENESIS; CHOLESTASIS; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; EPITHELIUM CELL; FLOW CYTOMETRY; GENETIC MANIPULATION; GENETIC RECOMBINATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY CELL; JAUNDICE; LIVER ATROPHY; LIVER FAILURE; LUNG ADENOCARCINOMA; LYMPH NODE METASTASIS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY FAILURE; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; TUNEL ASSAY; UPREGULATION; ANIMAL; BILE DUCT; BILE DUCT TUMOR; EPITHELIUM; GENETICS; INJURIES; METABOLISM; METASTASIS; MUTATION; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; BILE DUCT NEOPLASMS; BILE DUCTS; CADHERINS; CHOLANGIOCARCINOMA; EPITHELIUM; INTERLEUKIN-33; MICE; MICE, TRANSGENIC; MUTATION; NEOPLASM METASTASIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 85019135469     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1619416114     Document Type: Article

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