Antiphosphatidylserine/prothrombin antibodies as biomarkers to identify severe primary antiphospholipid syndrome

Clinical Chemistry and Laboratory Medicine

Volumn 55, Issue 6, 2017, Pages 890-898

  Hoxha, Ariela ^a   Mattia, Elena ^b   Tonello, Marta ^b   Grava, Chiara ^c   Pengo, Vittorio ^b   Ruffatti, Amelia ^b  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c SAN MARTINO HOSPITAL   (Italy)

Author keywords

anti phosphatidylserine prothrombin antibodies; antiphospholipid syndrome; lupus anticoagulant; pregnancy complications; thrombosis; thrombotic microangiopathy

Indexed keywords

BIOLOGICAL MARKER; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; PHOSPHATIDYLSERINE; PHOSPHOLIPID ANTIBODY; PROTHROMBIN ANTIBODY; PROTHROMBIN;

ADULT; ANTIBODY TITER; ANTIPHOSPHOLIPID SYNDROME; ARTERY THROMBOSIS; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FETUS WASTAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORBIDITY; PREGNANCY; PREMATURITY; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SPONTANEOUS ABORTION; THROMBOTIC THROMBOCYTOPENIC PURPURA; VEIN THROMBOSIS; BLOOD; IMMUNOLOGY; MIDDLE AGED; RETROSPECTIVE STUDY;

ADULT; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; BIOMARKERS; FEMALE; HUMANS; MALE; MIDDLE AGED; PHOSPHATIDYLSERINES; PREGNANCY; PROTHROMBIN; RETROSPECTIVE STUDIES;

EID: 85019105721     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2016-0638     Document Type: Article

References (33)

1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295-306.
2. Bertolaccini ML, Amengual O, Atsumi T, Binder WL, de Laat B, Forastiero R, et al. 'Non-criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on antiphospholipid Antibodies, Galveston, TX, USA, April 2010. Lupus, 2011;20:191-205.
3. Atsumi T, Ieko M, Bertolaccini ML, Ichikawa K, Tsutsumi A, Matsuura E, et al. Association of autoantibodies against the phosphatidylserine-prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant. Arthritis Rheum 2000;43:1982-93.
4. Peterson LK, Willis R, Harris EN, Branch WD, Tebo AE. Antibodies to phosphatidylserine/prothrombin complex in antiphospholipid syndrome: analytical and clinical perspectives. Adv Clin Chem 2016;73:1-28.
5. Sciascia S, Sanna G, Murru V, Roccatello D, Khamashta MA, Bertolaccini ML. Anti-prothrombin (aPT) and anti-phosphatidylserine/ prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome. A systematic review. Thromb Haemost 2014;111:354-64.
6. Bertolaccini ML, Sciascia S, Murru V, Garcia-Fernandez C, Sanna G, Khamashta MA. Prevalence of antibodies to prothrombin in solid phase (aPT) and to phosphatidylserine-prothrombin complex (aPS/PT) in patients with and without lupus anticoagulant. Thromb Haemost 2013;109:207-13.
7. Matsuda J, Saitoh N, Gotoh M, Kawasugi K, Gohchi K, Tsukamoto M. Phosphatidylserine-dependent antiprothrombin antibody is exclusive to patients with lupus anticoagulant. Br J Rheumatol 1996;35:589-91.
8. Pregnolato F, Chighizola CB, Encabo S, Shums Z, Norman GL, Tripodi A, et al. Anti-phosphatidylserine/prothrombin antibodies: an additional diagnostic marker for APS? Immunol Res 2013;56:432-8.
9. Hoxha A, Ruffatti A, Tonello M, Bontadi A, Salvan E, Banzato A, et al. Antiphosphatidylserine/prothrombin antibodies in primary antiphospholipid syndrome. Lupus 2012;21:787-9.
10. Hoxha A, Ruffatti A, Mattia E, Meneghel L, Tonello M, Salvan E, et al. Relationship between antiphosphatidylserine/ prothrombin and conventional antiphospholipid antibodies in primary antiphospholipid syndrome. Clin Chem Lab Med 2015;53:1265-70.
11. Sciascia S, Sanna G, Murru V, Roccatello D, Khamashta MA, Bertolaccini ML. GAPSS: the global anti-phospholipid syndrome score. Rheumatology (Oxford) 2013;52:1397-403.
12. Sciascia S, Sanna G, Murru V, Khamashta MA, Bertolaccini ML. Validation of a commercially available kit to detect anti-phosphatidylserine/ prothrombin antibodies in a cohort of systemic lupus erythematosus patients. Thromb Res 2014;133:451-4.
13. Tincani A, Allegri F, Balestrieri G, Reber G, Sanmarco M, Meroni PL, et al. Minimal requirements for antiphospholipid antibodies ELISAs proposed by the European Forum on antiphospholipid antibodies. Thromb Res 2004;114:553-8.
14. Reber G, Tincani A, Sanmarco M, de Moerloose P, Boffa MC. Proposals for the measurement of anti-b2-glycoprotein I antibodies. Standardization group of the European forum on antiphospholipid antibodies. J Thromb Haemost 2004;2:1860-2.
15. Ruffatti A, Olivieri S, Tonello M, Bortolatti M, Bison E, Salvan E, et al. Influence of different IgG anticardiolipin antibody cut-off values on antiphospholipid syndrome classification. J Thromb Haemost 2008;6:1693-6.
16. Harris EN, Pierangeli SS. Revisiting the anticardiolipin test and its standardization. Lupus 2002;11:269-75.
17. Forastiero R, Papalardo E, Watkins M, Nguyen H, Quirbach C, Jaskal K, et al. Evaluation of different immunoassays for the detection of antiphospholipid antibodies: report of a wet workshop during the 13th international congress on antiphospholipid antibodies. Clin Chim Acta 2014;428:99-105.
18. Clinical and Laboratory Standards Institute. User verification of performance for precision and trueness; approved guidelines. 2nd ed. EP 15-A2. Wayne, PA: Clinical and Laboratory Standards Institute, 2005.
19. Pengo V, Tripodi A, Reber G, Rand JH, Ortel TL, Galli M, et al; Subcommittee on lupus anticoagulant/antiphospholipid antibody of the scientific and standardisation committee of the international society on thrombosis and haemostasis. Update of the guidelines for lupus anticoagulant detection. Subcommittee on lupus anticoagulant/antiphospholipid antibody of the scientific and standardisation committee of the international society on thrombosis and haemostasis. J Thromb Haemost 2009;7:1737-40.
20. Bertolaccini ML, Atsumi T, Koike T, Hughes GR, Khamashta MA. Antiprothrombin antibodies detected in two different assay systems. Prevalence and clinical significance in systemic lupus erythematosus. Thromb Haemost 2005;93:289-97.
21. Vlagea A, Gil A, Cuesta MV, Arribas F, Diez J, Lavilla P, et al. Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential markers of antiphospholipid syndrome. Clin Appl Thromb Hemost 2013;19:289-96.
22. Nojima J, Iwatani Y, Suehisa E, Kuratsune H, Kanakura Y. The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus. Haematologica 2006:91:699-702.
23. Ruffatti A, Tonello M, Visentin MS, Bontadi A, Hoxha A, De Carolis S, et al. Risk factors for pregnancy failure in patients with anti-phospholipid syndrome treated with conventional therapies: a multicentre,case-control study. Rheumatology (Oxford) 2011;50:1684-9.
24. Asherson RA, Cervera R, Pierangeli SS. Microangiopathic antiphospholipid syndromes (MAPS) revisited-new concepts relating to antiphospholipid antibodies and syndromes. J Rheumatol 2007;34:1793-5.
25. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Preeclampsia. Lancet 2010;376:631-44.
26. Pengo V, Biasiolo A, Pegoraro C, Cucchini U, Noventa F, Iliceto S. Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb Haemost 2005;93:147-52.
27. Ruffatti A, Tonello M, Del Ross T, Cavazzana A, Grava C, Noventa F, et al. Antibody profile and clinical course in primary antiphospholipid syndrome and pregnancy morbidity. Thromb Haemost 2006;96:337-41.
28. Pengo V, Ruffatti A, Legnani C, Gresele P, Barcellona D, Erba N, et al. Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. J Thromb Haemost 2010;8:237-42.
29. Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 2003;101:1827-32.
30. Andreoli L, Chighizola CB, Banzato A, Pons-Estel GJ, Ramire de Jesus G, Erkan D. Estimated frequency of antiphospholipid antibodies in patients with pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature. Arthritis Care Res 2013;65:1869-73.
31. Yelnik CM, Laskin CA, Porter TF, Branch DW, Buyon JP, Guerra MM, et al. Lupus anticoagulant is the main predictor of adverse pregnancy outcomes in aPL-positive patients: validation of PROMISSE study results.Lupus Sci Med 2016;3:e000131.
32. Ruffatti A, Calligaro A, Hoxha A, Trevisanuto D, Ruffatti AT, Gervasi MT, et al. Laboratory and clinical features of pregnant women with antiphospholipid syndrome and neonatal outcome. Arthritis Care Res 2010;62:302-7.
33. Ruffatti A, Del Ross T, Ciprian M, Bertero MT, Sciascia S, Scarpato S, et al. Antiphospholipid syndrome study group of Italian society of rheumatology. Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study. Ann Rheum Dis 2011;70:1083-6.