Anti-phosphatidylserine/prothrombin antibodies: An additional diagnostic marker for APS?

Immunologic Research

Volumn 56, Issue 2-3, 2013, Pages 432-438

  Pregnolato, Francesca ^a   Chighizola, Cecilia B ^a,b   Encabo, Susan ^c   Shums, Zakera ^c   Norman, Gary L ^c   Tripodi, Armando ^b,d   Chantarangkul, Veena ^b,d   Bertero, Tiziana ^e   De Micheli, Valeria ^f   Borghi, Maria Orietta ^a,b   Meroni, Pier Luigi ^a,b,g  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c INOVA DIAGNOSTICS INC   (United States)

^d FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^e MAURIZIANO HOSPITAL   (Italy)

^f Azienda Ospedaliera della Provincia di Lecco   (Italy)

^g ISTITUTO ORTOPEDICO GAETANO PINI   (Italy)

Author keywords

Anti phosphatidylserine prothrombin antibodies; Anti phospholipid antibodies; Anti phospholipid antibody syndrome; Lupus anticoagulant

Indexed keywords

BETA2 GLYCOPROTEIN 1; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ANTICOAGULANT; PHOSPHATIDYLSERINE; PROTHROMBIN; PROTHROMBIN ANTIBODY;

ADULT; AGED; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIGENS; BIOLOGICAL MARKERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LUPUS COAGULATION INHIBITOR; MIDDLE AGED; PHOSPHATIDYLSERINES; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTHROMBIN; SENSITIVITY AND SPECIFICITY; SEROLOGIC TESTS; THROMBOSIS; YOUNG ADULT;

EID: 84879555559     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-013-8421-z     Document Type: Article

References (29)

1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, De Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:259-306.
2. Galli M, Barbui T. Antiprothrombin antibodies: detection and clinical significance in the antiphospholipid syndrome. Blood. 1999;93:2149-57. (Pubitemid 29153614)
3. Amengual O, Atsumi T, Koike T. Specificities, Properties, and Clinical Significance of Antiprothrombin Antibodies. Arthritis Rheum. 2003;48:886-95. (Pubitemid 36418230)
4. Vega-Ostertag M, Liu X, Kwan-Ki H, Chen P, Pierangeli S. A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E-selectin on endothelial cells. Br J Haematol. 2006;135:214-9. (Pubitemid 44401619)
5. Yang YH, Chang CJ, Chuang YH, Hsu HY, Chen PP, Chiangf BL. Identification of anti-prothrombin antibodies in the antiphospholipid syndrome that display the prothrombinase activity. Rheumatology. 2010;49:34-42.
6. Meroni PL, Borghi MO, Raschi E, Tedesco F. Pathogenesis of antiphospholipid syndrome: understanding the antibodies. Nature Rev Rheumatol. 2011;7:330-9.
7. Arvieux J, Darnige L, Caron C, Reber G, Bensa JC, Colomb MG. Development of an ELISA for autoantibodies to prothrombin showing their prevalence in patients with lupus anticoagulants. Thromb Haemost. 1995;74:1120-5.
8. Bevers EM, Galli M, Barbui T, Comfurius P, Zwaal RF. Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb Haemost. 1991;66:629-32.
9. Galli M, Beretta G, Daldossi M, Bevers EM, Barbui T. Different anticoagulant and immunological properties of anti-prothrombin antibodies in patients with antiphospholipid antibodies. Thromb Haemost. 1997;77:486-91. (Pubitemid 27121014)
10. Galli M, Luciani D, Bertolini G, Barbui T. Anti-β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome. Blood. 2003;102:2717-23. (Pubitemid 37248837)
11. Atsumi T, Koike K. Antiprothrombin antibody: why do we need more assays? Lupus. 2010;19:436-9.
12. Tincani A, Morozzi G, Villalta D, Alessandri C, Allegri F, Bistoni O, Bizzaro N, Caccavo D, Galeazzi M, Gerli R, Giovannelli L, Longobardo G, Lotzniker M, Malacarne F, Migliorini P, Parodi A, Pregnolato F, Radice A, Riccieri V, Ruffelli M, Sinico RA, Tozzoli R, Villalta D, Marcolongo R. Meroni P; Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA). Antiprothrombin antibodies: comparative analysis of home made and commercial methods. A collaborative work of the FIRMA group. Clin Exp Rheumatol. 2007;25:268-74.
13. Forastiero R, Papalardo E, Watkins M, Nguyen H, Crisostomo M, Vandam W, Hardy J, Albesa R, Nelson V, Shums Z, Norman G, Binder W, Morin K, Kirbach C, Mattias K, Lakos G, Pierangeli SS. Evaluation of the performance of monoclonal and polyclonal antibody standards in different assays for the detection of antiphospholipid (aPL) antibodies: report of a wet workshop at the 13th international congress on antiphospholipid antibodies. Arthr Rheum. 2010;62:2251.
14. 2glycoprotein I antibodies. A marker of antiphospholipid syndrome? Lupus. 1995;4:122-30.
15. Meroni PL, Mari D, Monti D, Coppola R, Capri M, Salvioli S, Tincani A, Gerli R, Franceschi C. Anti-beta 2 glycoprotein I antibodies in centenarians. Exp Gerontol. 2004;39:1459-65. (Pubitemid 39410545)
16. Tincani A, Spatola L, Prati E, Allegri F, Ferremi P, Cattaneo R, Meroni P, Balestrieri G. The aβ2glycoprotein I activity in human anti-phospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native β2-glycoprotein I and preserved during species' evolution. J Immunol. 1996;157:5732-8. (Pubitemid 126448998)
17. Roubey RAS, Eisenberg RA, Harper MF, Winfield JB. " Anticardiolipin" autoantibodies recognize β2-Glycoprotein I in the Absence of Phospholipid. Importance of Ag Density and Bivalent Binding. J Immunology. 1995;154:954-60.
18. Atsumi T, Ieko M, Bertolaccini ML, Ichikawa K, Tsutsumi A, Matsuura E, Koike T. Association of autoantibodies against the phosphatidylserine- prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant. Arthritis Rheum. 2000;43:1982-93.
19. Jakowski TD, Wilson AR, Hill HR, Branch WD, Tebo AE. Autoantibodies against phosphatidylserine, prothrombin and phosphatidylserine-prothrombin complex: identical or distinct diagnostic tools for antiphospholipid syndrome? Clin Chim Acta. 2009;410:19-24.
20. Atsumi T, Amengual O, Yasuda S, Koike T. Antiprothrombin antibodies - are they worth assaying? Thromb Res. 2004;114:533-8. (Pubitemid 39422588)
21. Miyara M, Arnaud L, Dufat L, Diement MC. Anti-phosphatidylserine/ prothrombin antibody titers are strongly correlated with lupus anticoagulant assays in patients with antiphospholipid antibodies. Arthritis Rheum. 2011;63:S7.
22. Bertolaccini ML, Atsumi T, Koike T, Hughes GRV, Khamashta MA. Antiprothrombin antibodies detected in two different assay systems. Prevalence and clinical significance in systemic lupus erythematosus. Thromb Haemost. 2005;93:289-97.
23. Forastiero R, Martinuzzo M, Pombo G, Puente D, Rossi A, Celebrin L, Bonaccorso S, Aversa L. A prospective study of autoantibody to β2-glycoprotein I and prothrombin, and risk of thrombosis. J Thromb Haemost. 2005;3:1231-8. (Pubitemid 41725247)
24. Bertolaccini ML, Sciascia S, Murru V, Garcia-Fernandez C, Sanna G, Khamashta M. Antibodies to phosphatidylserine/prothrombin (aPS/PT) are an independent risk factor for thrombosis in patients with systemic lupus erythematosus (SLE). Arthritis Rheum. 2011;63:S9.
25. von Landenberg P, Matthias T, Zaech J, Schultz M, Lorber M, Blank M, Shoenfeld Y. Antiprothrombin antibodies are associated with pregnancy loss in patients with the antiphospholipid syndrome. Am J Reprod Immunol. 2003;49:51-6. (Pubitemid 36612047)
26. Pengo V, Ruffatti A, Legnani C, Gresele P, Barcellona D, Erba N, Testa S, Marongiu F, Bison E, Denas G, Banzato A, Padayattil Jose S, Iliceto S. Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. J Thromb Haemost. 2010;8:237-42.
27. Rodriguez-Garcia JL, Bertolaccini ML, Cuadrado MJ, Sanna G, Ateka-Barrutia O, Khamashta MA. Clinical manifestations of antiphospholipid syndrome (APS) with and without antiphospholipid antibodies (the so-called 'seronegative APS'). Ann Rheum Dis. 2012;71:242-4.
28. Lakos G, Kiss E, Regeczy N, Tarjan P, Soltesz P, Zeher M, Bodolay E, Szucs G, Szakony S, Sipka S, Szegedi G. Anti-prothrombin and anti-annexin V antibodies imply risk of thrombosis in patients with systemic autoimmune diseases. J Rheumatol. 2000;27:924-9. (Pubitemid 30389748)
29. 2-glycoprotein-I and anti-prothrombin antibody fragments generated by phage display from a patient with primary antiphospholipid syndrome. J Autoimmun. 2006;26:57-65. (Pubitemid 43138894)