Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli

Molecular Biology and Evolution

Volumn 34, Issue 5, 2017, Pages 1029-1039

  Huseby, Douglas L ^a   Pietsch, Franziska ^a   Brandis, Gerrit ^a   Garoff, Linnéa ^a   Tegehall, Angelica ^a   Hughes, Diarmaid ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Ciprofloxacin; Clinical isolates; Modeling evolution; Multistep evolution; Population bottleneck

Indexed keywords

CIPROFLOXACIN; ANTIINFECTIVE AGENT; BACTERIAL DNA; ESCHERICHIA COLI PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SENSITIVITY; ESCHERICHIA COLI; FITNESS; GENE FREQUENCY; GENE MUTATION; GENOTYPE; IN VITRO STUDY; MATHEMATICAL MODEL; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; MUTATION RATE; NONHUMAN; POPULATION SIZE; WILD TYPE; DRUG EFFECTS; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MUTATION;

ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; GENOTYPE; MICROBIAL SENSITIVITY TESTS; MUTATION;

EID: 85019092793     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msx052     Document Type: Article

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