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Volumn 74, Issue , 2017, Pages 43-46

Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors: Shaping the future after the further cardiovascular outcomes research with PCSK9 inhibition in subjects with elevated risk (FOURIER) trial

Author keywords

[No Author keywords available]

Indexed keywords

ALIROCUMAB; BOCOCIZUMAB; EVOLOCUMAB; EZETIMIBE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INCLISIRAN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROPROTEIN CONVERTASE 9; SERINE PROTEINASE INHIBITOR; SIMVASTATIN; TRIACYLGLYCEROL; HYPOCHOLESTEROLEMIC AGENT; MONOCLONAL ANTIBODY; PCSK9 PROTEIN, HUMAN;

EID: 85018990636     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2017.04.007     Document Type: Editorial
Times cited : (20)

References (32)
  • 1
    • 85026391839 scopus 로고    scopus 로고
    • PCSK9 inhibitors: a new era of lipid lowering therapy
    • Chaudhary, R., Garg, J., Shah, N., Sumner, A., PCSK9 inhibitors: a new era of lipid lowering therapy. World J Cardiol 9:2 (2017), 76–91.
    • (2017) World J Cardiol , vol.9 , Issue.2 , pp. 76-91
    • Chaudhary, R.1    Garg, J.2    Shah, N.3    Sumner, A.4
  • 2
    • 85047288830 scopus 로고    scopus 로고
    • PCSK9 inhibitors: monoclonal antibodies for the treatment of hypercholesterolemia
    • Paton, D.M., PCSK9 inhibitors: monoclonal antibodies for the treatment of hypercholesterolemia. Drugs Today (Barc) 52:3 (2016), 183–192.
    • (2016) Drugs Today (Barc) , vol.52 , Issue.3 , pp. 183-192
    • Paton, D.M.1
  • 3
    • 84966293831 scopus 로고    scopus 로고
    • PCSK9 inhibition in the management of hyperlipidemia: focus on evolocumab
    • Blom, D.J., Dent, R., Castro, R.C., Toth, P.P., PCSK9 inhibition in the management of hyperlipidemia: focus on evolocumab. Vasc Health Risk Manag 12 (2016), 185–197.
    • (2016) Vasc Health Risk Manag , vol.12 , pp. 185-197
    • Blom, D.J.1    Dent, R.2    Castro, R.C.3    Toth, P.P.4
  • 4
    • 85009986038 scopus 로고    scopus 로고
    • Increased risk of adverse neurocognitive outcomes with proprotein convertase subtilisin-kexin type 9 inhibitors
    • Khan, A.R., Bavishi, C., Riaz, H., Farid, T.A., Khan, S., Atlas, M., et al. Increased risk of adverse neurocognitive outcomes with proprotein convertase subtilisin-kexin type 9 inhibitors. Circ Cardiovasc Qual Outcomes, 10(1), 2017.
    • (2017) Circ Cardiovasc Qual Outcomes , vol.10 , Issue.1
    • Khan, A.R.1    Bavishi, C.2    Riaz, H.3    Farid, T.A.4    Khan, S.5    Atlas, M.6
  • 10
    • 84908322310 scopus 로고    scopus 로고
    • Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial
    • Schwartz, G.G., Bessac, L., Berdan, L.G., Bhatt, D.L., Bittner, V., Diaz, R., et al. Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial. Am Heart J 168:5 (2014), 682–689.
    • (2014) Am Heart J , vol.168 , Issue.5 , pp. 682-689
    • Schwartz, G.G.1    Bessac, L.2    Berdan, L.G.3    Bhatt, D.L.4    Bittner, V.5    Diaz, R.6
  • 11
    • 85007568915 scopus 로고    scopus 로고
    • Effect of Evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial
    • Nicholls, S.J., Puri, R., Anderson, T., Ballantyne, C.M., Cho, L., Kastelein, J.J., et al. Effect of Evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial. JAMA 316:22 (2016), 2373–2384.
    • (2016) JAMA , vol.316 , Issue.22 , pp. 2373-2384
    • Nicholls, S.J.1    Puri, R.2    Anderson, T.3    Ballantyne, C.M.4    Cho, L.5    Kastelein, J.J.6
  • 12
    • 84992092089 scopus 로고    scopus 로고
    • 2016 ESC/EAS guidelines for the management of dyslipidaemias: the Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European atherosclerosis Society (EAS) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
    • Catapano, A.L., Graham, I., De Backer, G., Wiklund, O., Chapman, M.J., Drexel, H., et al. 2016 ESC/EAS guidelines for the management of dyslipidaemias: the Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European atherosclerosis Society (EAS) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis 253 (2016), 281–344.
    • (2016) Atherosclerosis , vol.253 , pp. 281-344
    • Catapano, A.L.1    Graham, I.2    De Backer, G.3    Wiklund, O.4    Chapman, M.J.5    Drexel, H.6
  • 13
    • 84865147415 scopus 로고    scopus 로고
    • Pharmacotherapy: statins and new-onset diabetes mellitus–a matter for debate
    • Athyros, V.G., Mikhailidis, D.P., Pharmacotherapy: statins and new-onset diabetes mellitus–a matter for debate. Nat Rev Endocrinol 8:3 (2012), 133–134.
    • (2012) Nat Rev Endocrinol , vol.8 , Issue.3 , pp. 133-134
    • Athyros, V.G.1    Mikhailidis, D.P.2
  • 14
    • 84924981752 scopus 로고    scopus 로고
    • Statin intolerance - an attempt at a unified definition. Position paper from an international lipid Expert Panel
    • Banach, M., Rizzo, M., Toth, P.P., Farnier, M., Davidson, M.H., Al-Rasadi, K., et al. Statin intolerance - an attempt at a unified definition. Position paper from an international lipid Expert Panel. Arch Med Sci 11:1 (2015), 1–23.
    • (2015) Arch Med Sci , vol.11 , Issue.1 , pp. 1-23
    • Banach, M.1    Rizzo, M.2    Toth, P.P.3    Farnier, M.4    Davidson, M.H.5    Al-Rasadi, K.6
  • 15
    • 84901200014 scopus 로고    scopus 로고
    • Statin treatment and new-onset diabetes: a review of proposed mechanisms
    • Brault, M., Ray, J., Gomez, Y.H., Mantzoros, C.S., Daskalopoulou, S.S., Statin treatment and new-onset diabetes: a review of proposed mechanisms. Metabolism 63:6 (2014), 735–745.
    • (2014) Metabolism , vol.63 , Issue.6 , pp. 735-745
    • Brault, M.1    Ray, J.2    Gomez, Y.H.3    Mantzoros, C.S.4    Daskalopoulou, S.S.5
  • 16
    • 84927742065 scopus 로고    scopus 로고
    • Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel statement on assessment, aetiology and management
    • Stroes, E.S., Thompson, P.D., Corsini, A., Vladutiu, G.D., Raal, F.J., Ray, K.K., et al., European Atherosclerosis Society Consensus Panel, Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel statement on assessment, aetiology and management. Eur Heart J 36:17 (2015), 1012–1022.
    • (2015) Eur Heart J , vol.36 , Issue.17 , pp. 1012-1022
    • Stroes, E.S.1    Thompson, P.D.2    Corsini, A.3    Vladutiu, G.D.4    Raal, F.J.5    Ray, K.K.6    European Atherosclerosis Society Consensus Panel7
  • 17
    • 84923653355 scopus 로고    scopus 로고
    • New-onset diabetes and statins: throw the bath water out, but, please, keep the baby!
    • Katsiki, N., Rizzo, M., Mikhailidis, D.P., Mantzoros, C.S., New-onset diabetes and statins: throw the bath water out, but, please, keep the baby!. Metabolism 64:4 (2015), 471–475.
    • (2015) Metabolism , vol.64 , Issue.4 , pp. 471-475
    • Katsiki, N.1    Rizzo, M.2    Mikhailidis, D.P.3    Mantzoros, C.S.4
  • 19
    • 84995776151 scopus 로고    scopus 로고
    • Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: a meta-analysis
    • Lotta, L.A., Sharp, S.J., Burgess, S., Perry, J.R., Stewart, I.D., Willems, S.M., et al. Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: a meta-analysis. JAMA 316:13 (2016), 1383–1391.
    • (2016) JAMA , vol.316 , Issue.13 , pp. 1383-1391
    • Lotta, L.A.1    Sharp, S.J.2    Burgess, S.3    Perry, J.R.4    Stewart, I.D.5    Willems, S.M.6
  • 20
    • 84995611819 scopus 로고    scopus 로고
    • Exploring the Management of Statin Intolerant Patients: 2016 and beyond
    • Katsiki, N., Athyros, V.G., Karagiannis, A., Exploring the Management of Statin Intolerant Patients: 2016 and beyond. Curr Vasc Pharmacol 14:6 (2016), 523–533.
    • (2016) Curr Vasc Pharmacol , vol.14 , Issue.6 , pp. 523-533
    • Katsiki, N.1    Athyros, V.G.2    Karagiannis, A.3
  • 21
    • 85013391663 scopus 로고    scopus 로고
    • Design and rationale of the EBBINGHAUS trial: a phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-a cognitive study of patients enrolled in the FOURIER trial
    • Giugliano, R.P., Mach, F., Zavitz, K., Kurtz, C., Schneider, J., Wang, H., et al., EBBINGHAUS Investigators, Design and rationale of the EBBINGHAUS trial: a phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-a cognitive study of patients enrolled in the FOURIER trial. Clin Cardiol 40:2 (2017), 59–65.
    • (2017) Clin Cardiol , vol.40 , Issue.2 , pp. 59-65
    • Giugliano, R.P.1    Mach, F.2    Zavitz, K.3    Kurtz, C.4    Schneider, J.5    Wang, H.6    EBBINGHAUS Investigators7
  • 22
    • 85026352329 scopus 로고    scopus 로고
    • [Last accessed 28 March 2017]
    • http://www.ajmc.com/conferences/acc-2017/dr-robert-p-giugliano-on-the-results-of-the-ebbinghaus-evolocumab-cognitive-study [Last accessed 28 March 2017].
  • 24
    • 85018193517 scopus 로고    scopus 로고
    • Inclisiran in patients at high cardiovascular risk with elevated LDL cholesterol
    • Ray, K.K., Landmesser, U., Leiter, L.A., Kallend, D., Dufour, R., Karakas, M., et al. Inclisiran in patients at high cardiovascular risk with elevated LDL cholesterol. N Engl J Med 376:15 (2017), 1430–1440.
    • (2017) N Engl J Med , vol.376 , Issue.15 , pp. 1430-1440
    • Ray, K.K.1    Landmesser, U.2    Leiter, L.A.3    Kallend, D.4    Dufour, R.5    Karakas, M.6
  • 26
    • 85009180543 scopus 로고    scopus 로고
    • Cardiovascular disease and risk management. Sec. 9. In standards of medical Care in Diabetes 2017
    • American Diabetes Association, Cardiovascular disease and risk management. Sec. 9. In standards of medical Care in Diabetes 2017. Diabetes Care 40:Suppl. 1 (2017), S75–S87.
    • (2017) Diabetes Care , vol.40 , pp. S75-S87
    • American Diabetes Association1
  • 27
    • 85021644727 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists and American College of endocrinology guidelines for management of dyslipidemia and prevention of atherosclerosis
    • Jellinger, P.S., Handelsman, Y., Rosenblit, P.D., Bloomgarden, Z.T., Fonseca, V.A., Garber, A.J., et al. American Association of Clinical Endocrinologists and American College of endocrinology guidelines for management of dyslipidemia and prevention of atherosclerosis. Endocr Pract 23:Suppl 2 (2017), 1–87.
    • (2017) Endocr Pract , vol.23 , pp. 1-87
    • Jellinger, P.S.1    Handelsman, Y.2    Rosenblit, P.D.3    Bloomgarden, Z.T.4    Fonseca, V.A.5    Garber, A.J.6
  • 28
    • 85017617053 scopus 로고    scopus 로고
    • PCSK9 inhibition to reduce cardiovascular events
    • [Epub ahead of print]
    • Dullaart, R.P., PCSK9 inhibition to reduce cardiovascular events. N Engl J Med, 2017 [Epub ahead of print].
    • (2017) N Engl J Med
    • Dullaart, R.P.1
  • 29
    • 84969253441 scopus 로고    scopus 로고
    • What's next for dyslipidemia management? The 2013 ACC/AHA guidelines, the NLA recommendations, and beyond
    • Waite, L.H., Phan, Y.L., Spinler, S.A., What's next for dyslipidemia management? The 2013 ACC/AHA guidelines, the NLA recommendations, and beyond. J Am Pharm Assoc (2003) 56:3 (2016), 284–292.
    • (2016) J Am Pharm Assoc (2003) , vol.56 , Issue.3 , pp. 284-292
    • Waite, L.H.1    Phan, Y.L.2    Spinler, S.A.3
  • 30
    • 84976361934 scopus 로고    scopus 로고
    • 2016 ACC Expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Task Force on clinical expert consensus documents
    • Writing Committee, Lloyd-Jones, D.M., Morris, P.B., Ballantyne, C.M., Birtcher, K.K., Daly, D.D. Jr., et al. 2016 ACC Expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Task Force on clinical expert consensus documents. J Am Coll Cardiol 68:1 (2016), 92–125.
    • (2016) J Am Coll Cardiol , vol.68 , Issue.1 , pp. 92-125
    • Writing Committee1    Lloyd-Jones, D.M.2    Morris, P.B.3    Ballantyne, C.M.4    Birtcher, K.K.5    Daly, D.D.6
  • 31
    • 85016315696 scopus 로고    scopus 로고
    • European Society of Cardiology/European Atherosclerosis Society Task Force consensus statement on proprotein convertase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk
    • [pii: ehw480. Epub ahead of print]
    • Landmesser, U., John Chapman, M., Farnier, M., Gencer, B., Gielen, S., Hovingh, G.K., et al., European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS), European Society of Cardiology/European Atherosclerosis Society Task Force consensus statement on proprotein convertase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk. Eur Heart J, 2016 [pii: ehw480. Epub ahead of print].
    • (2016) Eur Heart J
    • Landmesser, U.1    John Chapman, M.2    Farnier, M.3    Gencer, B.4    Gielen, S.5    Hovingh, G.K.6    European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)7
  • 32
    • 85026374226 scopus 로고    scopus 로고
    • [Last accessed 28 March 2017]
    • http://pace-cme.org/2017/03/16/consistent-long-term-ldl-c-reduction-by-pcsk9-inhibitor-translates-into-cv-benefit-in-high-risk-patients-already-on-statins/ [Last accessed 28 March 2017].


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