NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats

Journal of Cellular Physiology

Volumn 232, Issue 10, 2017, Pages 2731-2740

  Tajiri, Naoki ^a   Quach, David M ^b   Kaneko, Yuji ^a   Wu, Stephanie ^b   Lee, David ^b   Lam, Tina ^b   Hayama, Ken L ^b   Hazel, Thomas G ^b   Johe, Karl ^b   Wu, Michael C ^c   Borlongan, Cesar V ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b Neuralstem Inc   (United States)

^c Neurodigitech LLC   (United States)

Author keywords

behavioral recovery; cerebral ischemia; neurite outgrowth; neurogenesis; pharmacotherapy; trophic factors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CELL PROTEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; KI 67 ANTIGEN; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROPROTECTIVE AGENT; NSI 189; SCF PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; AMINOPYRIDINE DERIVATIVE; MICROTUBULE ASSOCIATED PROTEIN; MTAP2 PROTEIN, RAT; NSI-189; PIPERAZINE DERIVATIVE;

ADULT; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BRAIN CORTEX; BRAIN PERFUSION; CELL DEATH; CELL MATURATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVOUS SYSTEM DEVELOPMENT; NEURITE OUTGROWTH; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; SUBVENTRICULAR ZONE; THERAPY EFFECT; UPREGULATION; ANIMAL; BRAIN; CELL CULTURE; CONVALESCENCE; DISEASE MODEL; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; MOTOR ACTIVITY; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOLOGY; SPRAGUE DAWLEY RAT; TIME FACTOR;

AMINOPYRIDINES; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; KI-67 ANTIGEN; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MOTOR ACTIVITY; NEUROGENESIS; NEURONAL OUTGROWTH; NEURONS; NEUROPROTECTIVE AGENTS; PIPERAZINES; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; TIME FACTORS;

EID: 85018862855     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.25847     Document Type: Article

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