A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model

PLoS ONE

Volumn 12, Issue 4, 2017, Pages

  Yuan, Xuan ^a   Li, Zhe ^a   Baines, Andrea C ^a   Gavriilaki, Eleni ^a   Ye, Zhaohui ^a   Wen, Zhexing ^a   Braunstein, Evan M ^a   Biesecker, Leslie G ^b   Cheng, Linzhao ^a   Dong, Xinzhong ^a   Brodsky, Robert A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; COMPLEMENT; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL GLYCAN-CLASS A PROTEIN;

ALLELE; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MEMBRANE DEPOLARIZATION; MENTAL DISEASE; MOUSE; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEURAL STEM CELL; NONHUMAN; PIGA GENE; PROTEIN FUNCTION; SYNAPSE; ANIMAL; CELL LINE; CYTOLOGY; CYTOTOXICITY TEST; GENETICS; HEMATOPOIESIS; IMMUNOLOGY; METABOLISM; MUTATION; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY;

ANIMALS; CELL LINE; COMPLEMENT SYSTEM PROTEINS; CYTOTOXICITY TESTS, IMMUNOLOGIC; HEMATOPOIESIS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MEMBRANE PROTEINS; MICE; MUTATION; NEURAL STEM CELLS; NEUROGENESIS; NEURONS;

EID: 85018844619     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0174074     Document Type: Article

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