Dissecting and manipulating the pathway for glycosylphosphatidylinositol-anchor biosynthesis

Current Opinion in Chemical Biology

Volumn 4, Issue 6, 2000, Pages 632-638

  Kinoshita, Taroh ^a   Inoue, Norimitsu ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINOTRANSFERASE; GLYCOSYLPHOSPHATIDYLINOSITOL; MANNOSE; PHOSPHATIDYLINOSITOL; PHOSPHOETHANOLAMINE;

BIOSYNTHESIS; LEISHMANIA MEXICANA; MAMMAL CELL; MOLECULAR CLONING; NONHUMAN; PROTEIN BINDING; REACTION ANALYSIS; REVIEW; SPECIES DIFFERENCE; TRYPANOSOMA BRUCEI; YEAST;

EID: 0033637430     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00151-4     Document Type: Review

References (33)

1. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1
2. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2
3. GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis
4. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: Correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate
5. Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminyl-phosphatidylinositol de-N-acetylases essential in glycosyl-phosphatidylinositol biosynthesis
6. Differences between the trypanosomal and human GIcNAc-PI de-N-acetylases of glycosylphosphatidylinositol membrane anchor biosynthesis
7. Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis
8. GPI anchor biosynthesis in yeast: Phosphoethanolamine is attached to the α1,4-linked mannose of the complete precursor glycophospholipid
9. Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol
10. MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast
11. Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity
12. Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose
13. YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanol-aminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast
14. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol
15. Cell surface display and intracellular trafficking of free glycosylphosphatidylinositols in mammalian cells
16. Segregation of glycosylphosphatidylinositol biosynthetic reactions in a subcompartment of the endoplasmic reticulum
17. Stimulation of glycosylphosphatidylinositol biosynthesis in mammalian cell-free systems by GTP hydrolysis: Evidence for the involvement of membrane fusion
18. Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana
19. Human dolicholphosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3
20. Recognition of the carboxyl-terminal signal for GPI modification requires translocation of its hydrophobic domain across the ER membrane
21. A cell-free assay for glycosylphosphatidylinositol anchoring in African trypanosomes
22. Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins
23. Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins
24. Mammalian glycophosphatidylinositol anchor transfer to proteins and posttransfer deacylation
25. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles
26. Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins
27. Amino acid residues in the ω-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins
28. Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei
29. Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei
30. Specialized fatty acid synthesis in African trypanosomes: Myristate for GPI anchors
31. Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana. Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling
32. Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI): Protein transamidase-provide insights into the biosynthesis and functions of GPI-anchored proteins
33. 3-(4-azidoanilido)uridine 5'-triphosphate identifies Gpi3p as the UDP-GIcNAc-binding subunit of the enzyme that catalyses formation of GIcAc-phosphatidylinositol, the first glycolipid intermediate in glycosylphosphatidylinositol synthesis