Are children's vitamin D levels and BMI associated with antibody titers produced in response to 2014–2015 influenza vaccine?

Human Vaccines and Immunotherapeutics

Volumn 13, Issue 7, 2017, Pages 1661-1665

  Lin, Chyongchiou J ^a   Martin, Judith M ^a   Cole, Kelly Stefano ^a   Zimmerman, Richard K ^a   Susick, Michael ^a   Moehling, Krissy K ^a   Levine, Min Z ^b   Spencer, Sarah ^b,c   Flannery, Brendan ^b   Nowalk, Mary Patricia ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c ATLANTA RESEARCH AND EDUCATION FOUNDATION   (United States)

Author keywords

antibodies; immunogenicity; influenza vaccine; obesity; vitamin D

Indexed keywords

HEMAGGLUTININ; IMMUNOMODULATING AGENT; INFLUENZA VACCINE; VITAMIN D; INACTIVATED VACCINE; LIVE VACCINE; VIRUS ANTIBODY;

ANTIBODY TITER; ARTICLE; BODY MASS; CHILD; CLINICAL ARTICLE; COMMUNICABLE DISEASE; ELECTRONIC MEDICAL RECORD; FEMALE; HEMAGGLUTINATION INHIBITION; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; INFECTION; MAJOR CLINICAL STUDY; MALE; OBESITY; PLASMA; SERUM; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ADOLESCENT; ANTIBODY PRODUCTION; BLOOD; IMMUNOLOGY; PRESCHOOL CHILD;

ADOLESCENT; ANTIBODIES, VIRAL; ANTIBODY FORMATION; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFLUENZA VACCINES; MALE; VACCINES, ATTENUATED; VACCINES, INACTIVATED; VITAMIN D;

EID: 85018831744     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.1080/21645515.2017.1299837     Document Type: Article

References (35)

1. Aranow C. Vitamin D and the immune system. J Investige Med 2011; 59(6):881-886; PMID:21527855; https://doi.org/10.2310/JIM.0b013e31821b8755
2. Maguire JL, Russell ML, Smieja M, Walter SD, Loeb M. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis 2013:57(3):392-7; cit289.
3. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010; 91(5):1255-60; PMID:20219962; https://doi.org/10.3945/ajcn.2009.29094
4. Science M, Maguire JL, Russell ML, Smieja M, Walter SD, Loeb M. Serum 25-hydroxyvitamin D level and influenza vaccine immunogenicity in children and adolescents. PloS one 2014; 9(1):e83553; PMID:24427274; https://doi.org/10.1371/journal.pone.0083553
5. Sundaram ME, Talbot HK, Zhu Y, Griffin MR, Spencer S, Shay DK, Coleman LA. Vitamin D is not associated with serologic response to influenza vaccine in adults over 50 years old. Vaccine 2013; 31(16):2057-61; PMID:23453766; https://doi.org/10.1016/j.vaccine.2013.02.028
6. Pereira-Santos M, Costa P, Assis A, Santos C, Santos D. Obesity and vitamin D deficiency:a systematic review and meta-analysis. Obes Rev 2015; 16(4):341-349; PMID:25688659; https://doi.org/10.1111/obr.12239
7. Brock K, Huang W-Y, Fraser D, Ke L, Tseng M, Stolzenberg-Solomon R, Peters U, Ahn J, Purdue M, Mason RS, et al. Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. J Steroid Biochem Mol Biol 2010; 121(1):462-466; PMID:20399270; https://doi.org/10.1016/j.jsbmb.2010.03.091
8. Ganji V, Zhang X, Shaikh N, Tangpricha V. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001–2006. Am J Clin Nutr 2011; 94(1):225-233; PMID:21613551; https://doi.org/10.3945/ajcn.111.013516
9. Gilbert-Diamond D, Baylin A, Mora-Plazas M, Marin C, Arsenault JE, Hughes MD, Willett WC, Villamor E. Vitamin D deficiency and anthropometric indicators of adiposity in school-age children:a prospective study. Am J Clin Nutr 2010; 92(6):1446-1451; PMID:20926524; https://doi.org/10.3945/ajcn.2010.29746
10. Karlsson EA, Beck MA. The burden of obesity on infectious disease. Exp Biol Med 2010;235(12):1412-1424; PMID:21127339; https://doi.org/10.1258/ebm.2010.010227
11. Sheridan PA, Paich HA, Handy J, Karlsson EA, Hudgens MG, Sammon AB, Holland LA, Weir S, Noah TL, Beck MA. Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obes 2012; 36(8):1072-1077; PMID:22024641; https://doi.org/10.1038/ijo.2011.208
12. Talbot H, Coleman L, Crimin K, Zhu Y, Rock MT, Meece J, Shay DK, Belongia EA, Griffin MR. Association between obesity and vulnerability and serologic response to influenza vaccination in older adults. Vaccine 2012; 30(26):3937-3943; PMID:22484350; https://doi.org/10.1016/j.vaccine.2012.03.071
13. Prevention Centers for Disease Control and Prevention. A SAS Program for the 2000 CDC Growth Charts (ages 0 to <20 years). 2016; http://www.cdc.gov/nccdphp/dnpao/growthcharts/resources/sas.htm. Accessed October14, 2016.
14. Network WHOGIS. Serological diagnosis of influenza by haemagglutination inhibition testing. In:Manual for the laboratory diagnosis and virological surveillance of influenza. Geneva, Switzerland:WHO; 2011.
15. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine:What clinicians need to know. J Clin Endocrinol Metab 2011; 96(1):53-58; https://doi.org/10.1210/jc.2010-2704
16. Moreno LA, Valtueña J, Pérez-López F, González-Gross M. Health effects related to low vitamin D concentrations:beyond bone metabolism. Ann Nutr Metab 2011; 59(1):22-27; PMID:22123633; https://doi.org/10.1159/000332070
17. Mansbach JM, Ginde AA, Camargo CA. Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years:do children need more vitamin D? Pediatrics 2009; 124(5):1404-1410; PMID:19951983; https://doi.org/10.1542/peds.2008-2041
18. Prevention Centers for Disease Control and Prevention. Childhood Obesity Facts. 2015; https://www.cdc.gov/obesity/data/childhood.html. Accessed October14, 2016.
19. Zimmerman RK, Lin CJ, Raviotta JM, Nowalk MP. Do Vitamin D levels affect antibody titers produced in response to HPV vaccine? Hum Vaccin Immunother 2015; 11(10):2345-9
20. Makariou S, Liberopoulos EN, Elisaf M, Challa A. Novel roles of vitamin D in disease:what is new in 2011? Eur J Inter Med 2011; 22(4):355-362; PMID:21767752; https://doi.org/10.1016/j.ejim.2011.04.012
21. Holick MF. Vitamin D deficiency. N Eng J Med 2007; 357(3):266-281; PMID:17634462; https://doi.org/10.1056/NEJMra070553
22. Man L, Zhang Z, Zhang M, Zhang Y. Association between vitamin D deficiency and insufficiency and the risk of childhood asthma:evidence from a meta-analysis. Int J Clin Exp Med 2015; 8(4):5699; PMID:26131154
23. Tavera-Mendoza LE, White JH. Cell defenses and the sunshine vitamin. Sci Am 2007; 297(5):62-72; https://doi.org/10.1038/scientificamerican1107-62
24. Wang T-T, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J, Tavera-Mendoza L, Lin R, Hanrahan JW, Mader S, et al. Cutting edge:1, 25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004; 173(5):2909-2912; PMID:15322146; https://doi.org/10.4049/jimmunol.173.5.2909
25. Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1, 25-dihydroxyvitamin D 3. J Cyst Fibros 2007; 6(6):403-410; PMID:17467345; https://doi.org/10.1016/j.jcf.2007.03.003
26. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311(5768):1770-1773; PMID:16497887; https://doi.org/10.1126/science.1123933
27. Science M, Maguire JL, Russell ML, Smieja M, Walter SD, Loeb M. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis 2013; 57(3):392-397; PMID:23677871; https://doi.org/10.1093/cid/cit289
28. Ginde AA, Mansbach JM, Camargo CA. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 2009; 169(4):384-390; PMID:19237723; https://doi.org/10.1001/archinternmed.2008.560
29. Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1, 25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007; 179(3):1634-1647; PMID:17641030; https://doi.org/10.4049/jimmunol.179.3.1634
30. Lemire JM, Adams J, Sakai R, Jordan S. 1 alpha, 25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest 1984; 74(2):657-661; PMID:6611355; https://doi.org/10.1172/JCI111465
31. Bhalla AK, Amento E, Serog B, Glimcher L. 1, 25-Dihydroxyvitamin D3 inhibits antigen-induced T cell activation. J Immunol 1984; 133(4):1748-1754; PMID:6206136
32. Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O'Garra A. 1α, 25-Dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells. J Immunol 2001; 167(9):4974-4980; PMID:11673504; https://doi.org/10.4049/jimmunol.167.9.4974
33. Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L. Regulatory T cells induced by 1α, 25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 2001; 167(4):1945-1953; PMID:11489974; https://doi.org/10.4049/jimmunol.167.4.1945
34. Osterholm MT, Kelley NS, Sommer A, Belongia EA. Efficacy and effectiveness of influenza vaccines:a systematic review and meta-analysis. Lancet Infect Dis 2012; 12(1):36-44; PMID:22032844; https://doi.org/10.1016/S1473-3099(11)70295-X
35. Zimmerman RK, Nowalk MP, Chung J, Jackson ML, Jackson LA, Petrie JG, Monto AS, McLean HQ, Belongia EA, Gaglani M, et al. 2014–2015 Influenza vaccine effectiveness in the United States by vaccine type. Clin Infect Dis 2016; 63(12):1564-1573.