Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

Schizophrenia Research

Volumn 192, Issue , 2018, Pages 398-403

  Schwarz, Emanuel ^a   Maukonen, Johanna ^b   Hyytiäinen, Tiina ^b   Kieseppä, Tuula ^c   Orešič, Matej ^f,h   Sabunciyan, Sarven ^d   Mantere, Outi ^g   Saarela, Maria ^b   Yolken, Robert ^d   Suvisaari, Jaana ^e  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^f UNIVERSITY OF TURKU   (Finland)

^g DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^h STENO DIABETES CENTER   (Denmark)

Author keywords

Microbiome; Psychosis; Response; Schizophrenia

Indexed keywords

OLANZAPINE; QUETIAPINE; RISPERIDONE;

ADULT; ARTICLE; BACTEROIDES; BIFIDOBACTERIACEAE; BRIEF PSYCHIATRIC RATING SCALE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORIOBACTERIACEAE; DISEASE ASSOCIATION; DISEASE SEVERITY; FECES MICROFLORA; FEMALE; HUMAN; LACHNOSPIRACEAE; LACTOBACILLUS; MALE; METAGENOMICS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REMISSION; RUMINOCOCCACEAE; SCHIZOPHRENIA; TREATMENT RESPONSE; ADOLESCENT; FECES; FOLLOW UP; GENETICS; MICROBIOLOGY; MICROFLORA; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGICAL RATING SCALE; PSYCHOSIS; STATISTICAL MODEL; YOUNG ADULT;

ADOLESCENT; ADULT; FECES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LINEAR MODELS; MALE; MICROBIOTA; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 85018792632     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2017.04.017     Document Type: Article

References (36)

1. Hooper, L.V., et al. Molecular analysis of commensal host-microbial relations hips in the intestine. Science 291:5505 (2001), 881–884.
2. Adams, J.B., et al. Gastrointestinal flora and gastrointestinal status in children with autism—comparisons to typical children and correlation with autism severity. BMC Gastroenterol., 11, 2011, 22.
3. Andreasen, N.C., et al. Remission in schizophrenia: proposed criteria and rationale for consensus. Am. J. Psychiatr. 162:3 (2005), 441–449.
4. Andreasen, N.C., et al. Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs. Biol. Psychiatry 67:3 (2010), 255–262.
5. Araya, M., Joint FAO/WHO Working Group — Guidelines for the Evaluation of Probiotics in Food. 2002.
6. Benros, M.E., et al. Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study. Am. J. Psychiatr. 168:12 (2011), 1303–1310.
7. Benros, M.E., et al. Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry 70:8 (2013), 812–820.
8. Bercik, P., et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol. Motil. 23:12 (2011), 1132–1139.
9. Bergink, V., Gibney, S.M., Drexhage, H.A., Autoimmunity, inflammation, and psychosis: a search for peripheral markers. Biol. Psychiatry 75:4 (2014), 324–331.
10. Borre, Y.E., et al. Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol. Med. 20:9 (2014), 509–518.
11. Bravo, J.A., et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc. Natl. Acad. Sci. U. S. A. 108:38 (2011), 16050–16055.
12. Collins, S.M., Surette, M., Bercik, P., The interplay between the intestinal microbiota and the brain. Nat. Rev. Microbiol. 10:11 (2012), 735–742.
13. Cryan, J.F., Dinan, T.G., Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 13:10 (2012), 701–712.
14. Cuervo, A., et al. Pilot study of diet and microbiota: interactive associations of fibers and polyphenols with human intestinal bacteria. J. Agric. Food Chem. 62:23 (2014), 5330–5336.
15. Davey, K.J., et al. Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters. Psychopharmacology 221:1 (2012), 155–169.
16. Dinan, T., Borre, Y., Cryan, J., Genomics of schizophrenia: time to consider the gut microbiome?. Mol. Psychiatry 19:12 (2014), 1252–1257.
17. Evans, S.J., et al. The gut microbiome composition associates with bipolar disorder and illness severity. J. Psychiatr. Res. 87 (2017), 23–29.
18. Hooda, S., et al. 454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber. J. Nutr. 142:7 (2012), 1259–1265.
19. Hsiao, E.Y., et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155:7 (2013), 1451–1463.
20. Jiang, H., et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav. Immun. 48 (2015), 186–194.
21. Keinänen, J., et al. Early insulin resistance predicts weight gain and waist circumference increase in first-episode psychosis — a one year follow-up study. Schizophr. Res. 169:1–3 (2015), 458–463.
22. Männistö, S., et al. Monitoring diet and diet-related chronic disease risk factors in Finland. Public Health Nutr. 13:6A (2010), 907–914.
23. Maukonen, J., et al. PCR DGGE and RT-PCR DGGE show diversity and short-term temporal stability in the Clostridium coccoides-Eubacterium rectale group in the human intestinal microbiota. FEMS Microbiol. Ecol. 58:3 (2006), 517–528.
24. Milligan, G.W., Cooper, M.C., A study of standardization of variables in cluster analysis. J. Classif. 5:2 (1988), 181–204.
25. O'Hara, A.M., Shanahan, F., The gut flora as a forgotten organ. EMBO Rep. 7:7 (2006), 688–693.
26. Severance, E.G., et al. Gastrointestinal inflammation and associated immune activation in schizophrenia. Schizophr. Res. 138:1 (2012), 48–53.
27. Severance, E.G., et al. Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia. Schizophr. Res. 148:1–3 (2013), 130–137.
28. Severance, E.G., Gressitt, K.L., et al. Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder. Bipolar Disord. 16:3 (2014), 230–240.
29. Severance, E.G., Yolken, R.H., Eaton, W.W., Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling. Schizophr. Res. 176:1 (2016), 23–35.
30. Shor, D.B.-A., et al. Gastrointestinal-associated autoantibodies in different autoimmune diseases. Am. J. Clin. Exper. Immunol. 1:1 (2012), 49–55.
31. Simões, C.D., et al. Habitual dietary intake is associated with stool microbiota composition in monozygotic twins. J. Nutr. 143:4 (2013), 417–423.
32. de Theije, C.G.M., et al. Altered gut microbiota and activity in a murine model of autism spectrum disorders. Brain Behav. Immun. 37 (2014), 197–206.
33. Ventura, J., et al. Brief psychiatric rating scale (BPRS), expanded version (4.0): scales, anchor points, and administration manual. Int. J. Methods Psychiatr. Res. 3 (1993), 227–243.
34. Viitasalo, L., et al. Early microbial markers of celiac disease. J. Clin. Gastroenterol. 48:7 (2014), 620–624.
35. Yolken, R.H., et al. Metagenomic sequencing indicates that the oropharyngeal phageome of individuals with schizophrenia differs from that of controls. Schizophr. Bull. 41:5 (2015), 1153–1161.
36. Zhang, C., et al. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat. Commun., 4, 2013, 2163.