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Volumn 56, Issue 9, 2017, Pages 2035-2047

The miR-200b–ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma

Author keywords

cancer stem cells; CD24; hepatoma; microRNA; miR 200b; ZEB1

Indexed keywords

CD24 ANTIGEN; EPITHELIAL CELL ADHESION MOLECULE; MICRORNA 200B; MICROSOMAL AMINOPEPTIDASE; TRANSCRIPTION FACTOR ZEB1; DIFFERENTIATION ANTIGEN; DNA; MICRORNA; MIRN200 MICRORNA, HUMAN; ZEB1 PROTEIN, HUMAN;

EID: 85018579495     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22657     Document Type: Article
Times cited : (41)

References (53)
  • 1
    • 84978986530 scopus 로고    scopus 로고
    • Cancer stem cells and their cellular origins in primary liver and biliary tract cancers
    • Oikawa T. Cancer stem cells and their cellular origins in primary liver and biliary tract cancers. Hepatology. 2016; 49:645–651.
    • (2016) Hepatology , vol.49 , pp. 645-651
    • Oikawa, T.1
  • 3
    • 84952876320 scopus 로고    scopus 로고
    • Increased expression of circulating cancer stem cell markers during the perioperative period predicts early recurrence after curative resection of hepatocellular carcinoma
    • Choi GH, Kim GI, Yoo JE, et al. Increased expression of circulating cancer stem cell markers during the perioperative period predicts early recurrence after curative resection of hepatocellular carcinoma. Ann Surg Oncol. 2015; 22(Suppl 3):S1444–S1452.
    • (2015) Ann Surg Oncol , vol.22 , pp. S1444-S1452
    • Choi, G.H.1    Kim, G.I.2    Yoo, J.E.3
  • 4
    • 84891852738 scopus 로고    scopus 로고
    • Self-renewal as a therapeutic target in human colorectal cancer
    • Kreso A, van Galen P, Pedley NM, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med. 2014; 20:29–36.
    • (2014) Nat Med , vol.20 , pp. 29-36
    • Kreso, A.1    van Galen, P.2    Pedley, N.M.3
  • 6
    • 77956388547 scopus 로고    scopus 로고
    • CD13 is a therapeutic target in human liver cancer stem cells
    • Haraguchi N, Ishii H, Mimori K, et al. CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest. 2010; 120:3326–3339.
    • (2010) J Clin Invest , vol.120 , pp. 3326-3339
    • Haraguchi, N.1    Ishii, H.2    Mimori, K.3
  • 7
    • 79960006754 scopus 로고    scopus 로고
    • CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation
    • Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. Cell Stem Cell. 2011; 9:50–63.
    • (2011) Cell Stem Cell , vol.9 , pp. 50-63
    • Lee, T.K.1    Castilho, A.2    Cheung, V.C.3    Tang, K.H.4    Ma, S.5    Ng, I.O.6
  • 8
    • 84862777489 scopus 로고    scopus 로고
    • CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
    • Tang KH, Ma S, Lee TK, et al. CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling. Hepatology. 2012; 55:807–820.
    • (2012) Hepatology , vol.55 , pp. 807-820
    • Tang, K.H.1    Ma, S.2    Lee, T.K.3
  • 9
    • 38549139140 scopus 로고    scopus 로고
    • Significance of CD90+ cancer stem cells in human liver cancer
    • Yang ZF, Ho DW, Ng MN, et al. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell. 2008; 13:153–166.
    • (2008) Cancer Cell , vol.13 , pp. 153-166
    • Yang, Z.F.1    Ho, D.W.2    Ng, M.N.3
  • 10
    • 69949097533 scopus 로고    scopus 로고
    • CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery
    • Yang XR, Xu Y, Yu B, et al. CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery. Clin Cancer Res. 2009; 15:5518–5527.
    • (2009) Clin Cancer Res , vol.15 , pp. 5518-5527
    • Yang, X.R.1    Xu, Y.2    Yu, B.3
  • 11
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology. 2009; 136:1012–1024.
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3
  • 12
    • 84910652799 scopus 로고    scopus 로고
    • Hepatocellular carcinomas expressing “stemness”-related markers: clinicopathological characteristics
    • Kim H, Park YN. Hepatocellular carcinomas expressing “stemness”-related markers: clinicopathological characteristics. Dig Dis (Basel, Switzerland). 2014; 32:778–785.
    • (2014) Dig Dis (Basel, Switzerland) , vol.32 , pp. 778-785
    • Kim, H.1    Park, Y.N.2
  • 13
    • 84978402689 scopus 로고    scopus 로고
    • A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma
    • Yamashita M, Wada H, Eguchi H, et al. A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Int J Oncol. 2016; 49:89–98.
    • (2016) Int J Oncol , vol.49 , pp. 89-98
    • Yamashita, M.1    Wada, H.2    Eguchi, H.3
  • 14
    • 84910098336 scopus 로고    scopus 로고
    • Molecular biology of liver cancer stem cells
    • Oishi N, Yamashita T, Kaneko S. Molecular biology of liver cancer stem cells. Liver Cancer. 2014; 3:71–84.
    • (2014) Liver Cancer , vol.3 , pp. 71-84
    • Oishi, N.1    Yamashita, T.2    Kaneko, S.3
  • 15
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • Yamashita T, Forgues M, Wang W, et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res. 2008; 68:1451–1461.
    • (2008) Cancer Res , vol.68 , pp. 1451-1461
    • Yamashita, T.1    Forgues, M.2    Wang, W.3
  • 16
    • 84876098953 scopus 로고    scopus 로고
    • Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma
    • Yamashita T, Honda M, Nakamoto Y, et al. Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma. Hepatology. 2013; 57:1484–1497.
    • (2013) Hepatology , vol.57 , pp. 1484-1497
    • Yamashita, T.1    Honda, M.2    Nakamoto, Y.3
  • 17
    • 84901234680 scopus 로고    scopus 로고
    • The origin of cancer stem cells
    • Dang HT, Budhu A, Wang XW. The origin of cancer stem cells. J Hepatol. 2014; 60:1304–1305.
    • (2014) J Hepatol , vol.60 , pp. 1304-1305
    • Dang, H.T.1    Budhu, A.2    Wang, X.W.3
  • 18
    • 40949087185 scopus 로고    scopus 로고
    • Identification of metastasis-related microRNAs in hepatocellular carcinoma
    • Budhu A, Jia HL, Forgues M, et al. Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology. 2008; 47:897–907.
    • (2008) Hepatology , vol.47 , pp. 897-907
    • Budhu, A.1    Jia, H.L.2    Forgues, M.3
  • 19
    • 70349871321 scopus 로고    scopus 로고
    • MicroRNA expression, survival, and response to interferon in liver cancer
    • Ji J, Shi J, Budhu A, et al. MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med. 2009; 361:1437–1447.
    • (2009) N Engl J Med , vol.361 , pp. 1437-1447
    • Ji, J.1    Shi, J.2    Budhu, A.3
  • 20
    • 84865107292 scopus 로고    scopus 로고
    • MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma
    • Shih TC, Tien YJ, Wen CJ, et al. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatol. 2012; 57:584–591.
    • (2012) J Hepatol , vol.57 , pp. 584-591
    • Shih, T.C.1    Tien, Y.J.2    Wen, C.J.3
  • 21
    • 77956547097 scopus 로고    scopus 로고
    • Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
    • Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell. 2010; 39:761–772.
    • (2010) Mol Cell , vol.39 , pp. 761-772
    • Iliopoulos, D.1    Lindahl-Allen, M.2    Polytarchou, C.3    Hirsch, H.A.4    Tsichlis, P.N.5    Struhl, K.6
  • 22
    • 84868204026 scopus 로고    scopus 로고
    • Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma
    • Oishi N, Kumar MR, Roessler S, et al. Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma. Hepatology. 2012; 56:1792–1803.
    • (2012) Hepatology , vol.56 , pp. 1792-1803
    • Oishi, N.1    Kumar, M.R.2    Roessler, S.3
  • 23
    • 84931075204 scopus 로고    scopus 로고
    • MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis
    • Wong CM, Wei L, Au SL, et al. MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis. Oncotarget. 2015; 6:13658–13670.
    • (2015) Oncotarget , vol.6 , pp. 13658-13670
    • Wong, C.M.1    Wei, L.2    Au, S.L.3
  • 24
    • 84870346586 scopus 로고    scopus 로고
    • 1p36 tumor suppression—a matter of dosage
    • Henrich KO, Schwab M, Westermann F. 1p36 tumor suppression—a matter of dosage? Cancer Res. 2012; 72:6079–6088.
    • (2012) Cancer Res , vol.72 , pp. 6079-6088
    • Henrich, K.O.1    Schwab, M.2    Westermann, F.3
  • 25
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk U, Schubert J, Wellner U, et al. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008; 9:582–589.
    • (2008) EMBO Rep , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3
  • 26
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008; 283:14910–14914.
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 27
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 2008; 10:593–601.
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3
  • 28
    • 79951813950 scopus 로고    scopus 로고
    • The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    • Brabletz S, Bajdak K, Meidhof S, et al. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J. 2011; 30:770–782.
    • (2011) EMBO J , vol.30 , pp. 770-782
    • Brabletz, S.1    Bajdak, K.2    Meidhof, S.3
  • 29
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner U, Schubert J, Burk UC, et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol. 2009; 11:1487–1495.
    • (2009) Nat Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3
  • 30
    • 84894224148 scopus 로고    scopus 로고
    • The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression
    • Liu Y, Sanchez-Tillo E, Lu X, et al. The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression. J Biol Chem. 2014; 289:4116–4125.
    • (2014) J Biol Chem , vol.289 , pp. 4116-4125
    • Liu, Y.1    Sanchez-Tillo, E.2    Lu, X.3
  • 31
    • 84901641012 scopus 로고    scopus 로고
    • Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis
    • Bera R, Chiou CY, Yu MC, et al. Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. Hepatology. 2014; 59:2238–2250.
    • (2014) Hepatology , vol.59 , pp. 2238-2250
    • Bera, R.1    Chiou, C.Y.2    Yu, M.C.3
  • 32
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • Varambally S, Cao Q, Mani RS, et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science. 2008; 322:1695–1699.
    • (2008) Science , vol.322 , pp. 1695-1699
    • Varambally, S.1    Cao, Q.2    Mani, R.S.3
  • 33
    • 84908222388 scopus 로고    scopus 로고
    • Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion
    • Bracken CP, Li X, Wright JA, et al. Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. EMBO J. 2014; 33:2040–2056.
    • (2014) EMBO J , vol.33 , pp. 2040-2056
    • Bracken, C.P.1    Li, X.2    Wright, J.A.3
  • 34
    • 84874391749 scopus 로고    scopus 로고
    • Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma
    • Nishida N, Kudo M. Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma. Oncology. 2013; 84(Suppl 1):93–97.
    • (2013) Oncology , vol.84 , pp. 93-97
    • Nishida, N.1    Kudo, M.2
  • 35
    • 26944433502 scopus 로고    scopus 로고
    • High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma
    • Hsieh SY, Chen WY, Yeh TS, Sheen IS, Huang SF. High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma. Oncogene. 2005; 24:6584–6589.
    • (2005) Oncogene , vol.24 , pp. 6584-6589
    • Hsieh, S.Y.1    Chen, W.Y.2    Yeh, T.S.3    Sheen, I.S.4    Huang, S.F.5
  • 36
    • 84959121523 scopus 로고    scopus 로고
    • Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition
    • Haraguchi T, Kondo M, Uchikawa R, et al. Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition. Sci Rep. 2016; 6:21117.
    • (2016) Sci Rep , vol.6 , pp. 21117
    • Haraguchi, T.1    Kondo, M.2    Uchikawa, R.3
  • 37
    • 84923251407 scopus 로고    scopus 로고
    • Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
    • Chen L, Gibbons DL, Goswami S, et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun. 2014; 5:5241.
    • (2014) Nat Commun , vol.5 , pp. 5241
    • Chen, L.1    Gibbons, D.L.2    Goswami, S.3
  • 38
    • 84876738157 scopus 로고    scopus 로고
    • A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells
    • Lo SJ, Fan LC, Tsai YF, et al. A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells. Hepatology. 2013; 57:1893–1905.
    • (2013) Hepatology , vol.57 , pp. 1893-1905
    • Lo, S.J.1    Fan, L.C.2    Tsai, Y.F.3
  • 39
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006; 66:9339–9344.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 40
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008; 133:704–715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 41
    • 79957897561 scopus 로고    scopus 로고
    • SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation
    • Acun T, Oztas E, Yagci T, Yakicier MC. SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. BMC Cancer. 2011; 11:223.
    • (2011) BMC Cancer , vol.11 , pp. 223
    • Acun, T.1    Oztas, E.2    Yagci, T.3    Yakicier, M.C.4
  • 42
    • 84874927009 scopus 로고    scopus 로고
    • ZEB1 promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1
    • Sanchez-Tillo E, de Barrios O, Siles L, et al. ZEB1 promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1. Clin Cancer Res. 2013; 19:1071–1082.
    • (2013) Clin Cancer Res , vol.19 , pp. 1071-1082
    • Sanchez-Tillo, E.1    de Barrios, O.2    Siles, L.3
  • 43
    • 84864987692 scopus 로고    scopus 로고
    • Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon
    • Kim HM, Haraguchi N, Ishii H, et al. Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon. Ann Surg Oncol. 2012; 19(Suppl 3):S539–S548.
    • (2012) Ann Surg Oncol , vol.19 , pp. S539-S548
    • Kim, H.M.1    Haraguchi, N.2    Ishii, H.3
  • 44
    • 79956143950 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
    • Kim T, Veronese A, Pichiorri F, et al. P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med. 2011; 208:875–883.
    • (2011) J Exp Med , vol.208 , pp. 875-883
    • Kim, T.1    Veronese, A.2    Pichiorri, F.3
  • 45
    • 84939213173 scopus 로고    scopus 로고
    • CRKL oncogene is downregulated by p53 through miR-200s
    • Tamura M, Sasaki Y, Kobashi K, et al. CRKL oncogene is downregulated by p53 through miR-200s. Cancer Sci. 2015; 106:1033–1040.
    • (2015) Cancer Sci , vol.106 , pp. 1033-1040
    • Tamura, M.1    Sasaki, Y.2    Kobashi, K.3
  • 46
    • 0032530342 scopus 로고    scopus 로고
    • Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study
    • Coiffier B, Haioun C, Ketterer N, et al. Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study. Blood. 1998; 92:1927–1932.
    • (1998) Blood , vol.92 , pp. 1927-1932
    • Coiffier, B.1    Haioun, C.2    Ketterer, N.3
  • 47
    • 33749182067 scopus 로고    scopus 로고
    • The phenotypes of pluripotent human hepatic progenitors
    • Schmelzer E, Wauthier E, Reid LM. The phenotypes of pluripotent human hepatic progenitors. Stem Cells. 2006; 24:1852–1858.
    • (2006) Stem Cells , vol.24 , pp. 1852-1858
    • Schmelzer, E.1    Wauthier, E.2    Reid, L.M.3
  • 48
    • 34547803161 scopus 로고    scopus 로고
    • Human hepatic stem cells from fetal and postnatal donors
    • Schmelzer E, Zhang L, Bruce A, et al. Human hepatic stem cells from fetal and postnatal donors. J Exp Med. 2007; 204:1973–1987.
    • (2007) J Exp Med , vol.204 , pp. 1973-1987
    • Schmelzer, E.1    Zhang, L.2    Bruce, A.3
  • 49
    • 84892945531 scopus 로고    scopus 로고
    • Expression profile of microRNA-200 family in hepatocellular carcinoma with bile duct tumor thrombus
    • Yeh TS, Wang F, Chen TC, et al. Expression profile of microRNA-200 family in hepatocellular carcinoma with bile duct tumor thrombus. Ann Surg. 2014; 259:346–354.
    • (2014) Ann Surg , vol.259 , pp. 346-354
    • Yeh, T.S.1    Wang, F.2    Chen, T.C.3
  • 50
    • 84900316922 scopus 로고    scopus 로고
    • A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma
    • Yuan JH, Yang F, Wang F, et al. A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 2014; 25:666–681.
    • (2014) Cancer Cell , vol.25 , pp. 666-681
    • Yuan, J.H.1    Yang, F.2    Wang, F.3
  • 51
    • 84892828470 scopus 로고    scopus 로고
    • MicroRNA-200a and -200b mediated hepatocellular carcinoma cell migration through the epithelial to mesenchymal transition markers
    • Hung CS, Liu HH, Liu JJ, et al. MicroRNA-200a and -200b mediated hepatocellular carcinoma cell migration through the epithelial to mesenchymal transition markers. Ann Surg Oncol. 2013; 20(Suppl 3):S360–S368.
    • (2013) Ann Surg Oncol , vol.20 , pp. S360-S368
    • Hung, C.S.1    Liu, H.H.2    Liu, J.J.3
  • 52
    • 84948407218 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
    • Zheng X, Carstens JL, Kim J, et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 2015; 527:525–530.
    • (2015) Nature , vol.527 , pp. 525-530
    • Zheng, X.1    Carstens, J.L.2    Kim, J.3
  • 53
    • 84948429460 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
    • Fischer KR, Durrans A, Lee S, et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 2015; 527:472–476.
    • (2015) Nature , vol.527 , pp. 472-476
    • Fischer, K.R.1    Durrans, A.2    Lee, S.3


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