Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene

Journal of the American Chemical Society

Volumn 139, Issue 15, 2017, Pages 5293-5296

  Tinoco, Antonio ^a   Steck, Viktoria ^a   Tyagi, Vikas ^a   Fasan, Rudi ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CATALYSTS; ENANTIOSELECTIVITY; PROPANE; STEREOCHEMISTRY; STEREOSELECTIVITY;

ASYMMETRIC SYNTHESIS; CARBENE TRANSFER; DIASTEREO- AND ENANTIOSELECTIVITY; EFFICIENT STRATEGY; ENANTIOSELECTIVE SYNTHESIS; MEDICINAL CHEMISTRY; OLEFIN CYCLOPROPANATION; STEREOSELECTIVE SYNTHESIS;

DRUG PRODUCTS;

CARBENE; CYCLOPROPANE DERIVATIVE; METALLOPROTEIN; MYOGLOBIN; TRIFLUOROMETHYL SUBSTITUTED CYCLOPROPANES; TRIFLUOROMETHYLCARBENE; UNCLASSIFIED DRUG; FLUORINATED HYDROCARBON; METHANE;

ARTICLE; ASYMMETRIC SYNTHESIS; BIOCATALYST; CATALYST; CYCLOPROPANATION; DIAZOTIZATION; ELECTROPHILICITY; ENANTIOMER; ENANTIOSELECTIVITY; REACTION TIME; STEREOSELECTIVITY; ANALOGS AND DERIVATIVES; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; STEREOISOMERISM; SYNTHESIS;

CATALYSIS; CYCLOPROPANES; HYDROCARBONS, FLUORINATED; METHANE; MOLECULAR STRUCTURE; MYOGLOBIN; STEREOISOMERISM;

EID: 85018527313     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.7b00768     Document Type: Article

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