Plasma-derived exosomes contribute to inflammation via the TLR9-NF-κB pathway in chronic heart failure patients

Molecular Immunology

Volumn 87, Issue , 2017, Pages 114-121

  Ye, Wei ^a   Tang, Xiaojun ^a   Yang, Zhengquan ^a   Liu, Chu ^a   Zhang, Xin ^b   Jin, Jing ^a   Lyu, Jianxin ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Chronic heart failure; Exosomes; Inflammation; Mitochondrial DNA; Toll like receptor 9

Indexed keywords

CHLOROQUINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MITOCHONDRIAL DNA; TOLL LIKE RECEPTOR 9; TLR9 PROTEIN, HUMAN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; GENE DOSAGE; HEART FAILURE; HUMAN; HUMAN CELL; INFLAMMATION; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL CULTURE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

BASE SEQUENCE; CELLS, CULTURED; CHLOROQUINE; DNA, MITOCHONDRIAL; EXOSOMES; GENE DOSAGE; HEART FAILURE; HUMANS; INFLAMMATION; NF-KAPPA B; PLASMA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9;

EID: 85018498200     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2017.03.011     Document Type: Article

References (28)

1. Andre, F., Schartz, N.E., Movassagh, M., Flament, C., Pautier, P., Morice, P., Pomel, C., Lhomme, C., Escudier, B., Le Chevalier, T., Tursz, T., Amigorena, S., Raposo, G., Angevin, E., Zitvogel, L., Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360 (2002), 295–305.
2. Aukrust, P., Yndestad, A., Damas, J.K., Gullestad, L., Inflammation and chronic heart failure-potential therapeutic role of intravenous immunoglobulin. Autoimmun. Rev. 3 (2004), 221–227.
3. Bretz, N.P., Ridinger, J., Rupp, A.K., Rimbach, K., Keller, S., Rupp, C., Marme, F., Umansky, L., Umansky, V., Eigenbrod, T., Sammar, M., Altevogt, P., Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling. J. Biol. Chem. 288 (2013), 36691–36702.
4. Chow, A., Zhou, W., Liu, L., Fong, M.Y., Champer, J., Van Haute, D., Chin, A.R., Ren, X., Gugiu, B.G., Meng, Z., Huang, W., Ngo, V., Kortylewski, M., Wang, S.E., Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-kappaB. Sci. Rep., 4, 2014, 5750.
5. Damas, J.K., Gullestad, L., Aass, H., Simonsen, S., Fjeld, J.G., Wikeby, L., Ueland, T., Eiken, H.G., Froland, S.S., Aukrust, P., Enhanced gene expression of chemokines and their corresponding receptors in mononuclear blood cells in chronic heart failure–modulatory effect of intravenous immunoglobulin. J. Am. Coll. Cardiol. 38 (2001), 187–193.
6. Danesh, A., Inglis, H.C., Jackman, R.P., Wu, S., Deng, X., Muench, M.O., Heitman, J.W., Norris, P.J., Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro. Blood 123 (2014), 687–696.
7. Eiken, H.G., Oie, E., Damas, J.K., Yndestad, A., Bjerkeli, V., Aass, H., Simonsen, S., Geiran, O.R., Tonnessen, T., Christensen, G., Froland, S.S., Gullestad, L., Attramadal, H., Aukrust, P., Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure. Eur. J. Clin. Invest. 31 (2001), 389–397.
8. Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G.J., Zanesi, N., Crawford, M., Ozer, G.H., Wernicke, D., Alder, H., Caligiuri, M.A., Nana-Sinkam, P., Perrotti, D., Croce, C.M., MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), E2110–6.
9. Guescini, M., Guidolin, D., Vallorani, L., Casadei, L., Gioacchini, A.M., Tibollo, P., Battistelli, M., Falcieri, E., Battistin, L., Agnati, L.F., Stocchi, V., C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction. Exp. Cell Res. 316 (2010), 1977–1984.
10. Guescini, M., Genedani, S., Stocchi, V., Agnati, L.F., Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J. Neural Transm. (Vienna) 117 (2010), 1–4.
11. Helmig, S., Fruhbeis, C., Kramer-Albers, E.M., Simon, P., Tug, S., Release of bulk cell free DNA during physical exercise occurs independent of extracellular vesicles. Eur. J. Appl. Physiol. 115 (2015), 2271–2280.
12. Hendrix, A., Westbroek, W., Bracke, M., De Wever, O., An ex(o)citing machinery for invasive tumor growth. Cancer Res. 70 (2010), 9533–9537.
13. Janowska-Wieczorek, A., Wysoczynski, M., Kijowski, J., Marquez-Curtis, L., Machalinski, B., Ratajczak, J., Ratajczak, M.Z., Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int. J. Cancer 113 (2005), 752–760.
14. Jessup, M., Brozena, S., Heart failure. N. Engl. J. Med. 348 (2003), 2007–2018.
15. Lobb, R.J., Becker, M., Wen, S.W., Wong, C.S., Wiegmans, A.P., Leimgruber, A., Moller, A., Optimized exosome isolation protocol for cell culture supernatant and human plasma. J. Extracell. Vesicles, 4, 2015, 27031.
16. Lotvall, J., Valadi, H., Cell to cell signalling via exosomes through esRNA. Cell Adhes. Migr. 1 (2007), 156–158.
17. Mann, D.L., Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ. Res. 91 (2002), 988–998.
18. Mathivanan, S., Ji, H., Simpson, R.J., Exosomes: extracellular organelles important in intercellular communication. J. Proteomics 73 (2010), 1907–1920.
19. Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., Akira, S., Yamamoto, A., Komuro, I., Otsu, K., Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485 (2012), 251–255.
20. Pisitkun, T., Shen, R.F., Knepper, M.A., Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 13368–13373.
21. Raiborg, C., Rusten, T.E., Stenmark, H., Protein sorting into multivesicular endosomes. Curr. Opin. Cell Biol. 15 (2003), 446–455.
22. Raposo, G., Stoorvogel, W., Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200 (2013), 373–383.
23. Rupp, A.K., Rupp, C., Keller, S., Brase, J.C., Ehehalt, R., Fogel, M., Moldenhauer, G., Marme, F., Sultmann, H., Altevogt, P., Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage. Gynecol. Oncol. 122 (2011), 437–446.
24. Taylor, D.D., Akyol, S., Gercel-Taylor, C., Pregnancy-associated exosomes and their modulation of T cell signaling. J. Immunol. 176 (2006), 1534–1542.
25. Tian, T., Wang, Y., Wang, H., Zhu, Z., Xiao, Z., Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy. J. Cell. Biochem. 111 (2010), 488–496.
26. Torregrosa Paredes, P., Esser, J., Admyre, C., Nord, M., Rahman, Q.K., Lukic, A., Radmark, O., Gronneberg, R., Grunewald, J., Eklund, A., Scheynius, A., Gabrielsson, S., Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma. Allergy 67 (2012), 911–919.
27. Waldenstrom, A., Ronquist, G., Role of exosomes in myocardial remodeling. Circ. Res. 114 (2014), 315–324.
28. Zhang, B., Yin, Y., Lai, R.C., Tan, S.S., Choo, A.B., Lim, S.K., Mesenchymal stem cells secrete immunologically active exosomes. Stem Cells Dev. 23 (2014), 1233–1244.