Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress

Cancer Letters

Volumn 399, Issue , 2017, Pages 10-19

  Yang, Changwon ^a   Lim, Whasun ^b   Bazer, Fuller W ^c   Song, Gwonhwa ^a  

^a Korea University   (South Korea)

^b Catholic Kwandong University   (South Korea)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Apoptosis; Choriocarcinoma; Invasion; Myricetin; ROS

Indexed keywords

CISPLATIN; ETOPOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; MYRICETIN; PHOSPHATIDYLINOSITOL 3 KINASE; ANTINEOPLASTIC AGENT; FLAVONOID; OXIDIZING AGENT; PROTEIN KINASE B;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CANCER COMBINATION CHEMOTHERAPY; CELL CYCLE PROGRESSION; CELL DEATH; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CHORIOCARCINOMA; CHORIOCARCINOMA CELL LINE; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CALCIUM SIGNALING; CELL CYCLE; CELL MOTION; DOSE RESPONSE; DRUG EFFECTS; ENDOPLASMIC RETICULUM; FEMALE; METABOLISM; PATHOLOGY; PREGNANCY; TUMOR CELL LINE; TUMOR INVASION;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CALCIUM SIGNALING; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHORIOCARCINOMA; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ETOPOSIDE; FEMALE; FLAVONOIDS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM INVASIVENESS; OXIDANTS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASE; PREGNANCY; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 85018464730     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2017.04.014     Document Type: Article

References (10)

1. [1] Tidy, J.A., Rustin, G.J., Newlands, E.S., Foskett, M., Fuller, S., Short, D., et al. Presentation and management of choriocarcinoma after nonmolar pregnancy. Br. J. obstetrics Gynaecol. 102 (1995), 715–719.
2. [2] Kawamura, K., Kawamura, N., Okamoto, N., Manabe, M., Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling. Cancer Med. 2 (2013), 849–861.
3. [3] Lazovic, B., Milenkovic, V., Delic, M., Mazic, S., Jeremic, K., Hrgovic, Z., Hypersensitivity to etoposide in case of metastatic gestational choriocarcinoma. Case Rep. Oncol. 6 (2013), 490–492.
4. [4] Xu, Y., Xie, Q., Wu, S., Yi, D., Yu, Y., Liu, S., et al. Myricetin induces apoptosis via endoplasmic reticulum stress and DNA double-strand breaks in human ovarian cancer cells. Mol. Med. Rep. 13 (2016), 2094–2100.
5. [5] Lim, W., Yang, C., Bazer, F.W., Song, G., Chrysophanol induces apoptosis of choriocarcinoma through regulation of ROS and the AKT and ERK1/2 pathways. J. Cell Physiol. 232 (2017), 331–339.
6. [6] Seydi, E., Rasekh, H.R., Salimi, A., Mohsenifar, Z., Pourahmad, J., Myricetin selectively induces apoptosis on cancerous hepatocytes by directly targeting their mitochondria. Basic Clin. Pharmacol. Toxicol. 119 (2016), 249–258.
7. [7] Hosseinzadehdehkordi, M., Adelinik, A., Tashakor, A., Dual effect of curcumin targets reactive oxygen species, adenosine triphosphate contents and intermediate steps of mitochondria-mediated apoptosis in lung cancer cell lines. Eur. J. Pharmacol. 769 (2015), 203–210.
8. [8] Chen, F., Induction of oxidative stress and cytotoxicity by PCB126 in JEG-3 human choriocarcinoma cells. J. Environ. Sci. health. Part A Toxic/hazardous Subst. Environ. Eng. 45 (2010), 932–937.
9. [9] Qu, K., Shen, N.Y., Xu, X.S., Su, H.B., Wei, J.C., Tai, M.H., et al. Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction. Acta Pharmacol. Sin. 34 (2013), 1217–1228.
10. [10] Jeong, S.A., Kim, I.Y., Lee, A.R., Yoon, M.J., Cho, H., Lee, J.S., et al. Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me-induced apoptosis in breast cancer cells. Oncotarget 6 (2015), 21173–21192.