Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction

Acta Pharmacologica Sinica

Volumn 34, Issue 9, 2013, Pages 1217-1228

  Qu, Kai ^a   Shen, Nai Ying ^b   Xu, Xin Sen ^a   Su, Hai Bo ^a   Wei, Ji Chao ^a   Tai, Ming Hui ^a   Meng, Fan Di ^a   Zhou, Lei ^a   Zhang, Yue Lang ^a   Liu, Chang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Department of Cardiology   (China)

Author keywords

Apoptosis; Caspase; Emodin; Endoplasmic reticulum stress; Immunosuppressant; Intracellular Ca 2+; Mitochondrial dysfunction; N acetylcysteine; Reactive oxygen species; T cell

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 4; CASPASE 9; CYTOCHROME C; EMODIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; MALONALDEHYDE; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL GROWTH; CELL VIABILITY; COLORIMETRY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DOSE RESPONSE; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FLUORESCENCE; FLUOROMETRY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; LYMPHOCYTE COUNT; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RHUBARB; T LYMPHOCYTE; VENOUS BLOOD; WESTERN BLOTTING;

APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMODIN; ENDOPLASMIC RETICULUM STRESS; HUMANS; LEUKOCYTES, MONONUCLEAR; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; T-LYMPHOCYTES;

EID: 84880724522     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.58     Document Type: Article

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