Human CD8+ CD57- TEMRA cells: Too young to be called "old"

PLoS ONE

Volumn 12, Issue 5, 2017, Pages

  Verma, Kriti ^a,b   Ogonek, Justyna ^a   Varanasi, Pavankumar Reddy ^a   Luther, Susanne ^a   Bünting, Ivonne ^a   Thomay, Katrin ^a   Behrens, Yvonne Lisa ^a   Mischak Weissinger, Eva ^a   Hambach, Lothar ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Integrated Research and Treatment Center Transplantation   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CD57 ANTIGEN; GAMMA INTERFERON; PEPTIDE;

ADULT; AGED; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CD8+ T LYMPHOCYTE; CELL DEATH; CELL ISOLATION; CELL PLASTICITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOMEGALOVIRUS; CYTOTOXICITY; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MALE; MEMORY T LYMPHOCYTE; PHENOTYPE; T LYMPHOCYTE SUBPOPULATION; TELOMERE LENGTH; CELL CULTURE; CELL PROLIFERATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY;

ANTIGENS, CD57; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; IMMUNOLOGIC MEMORY; T-LYMPHOCYTE SUBSETS;

EID: 85018432094     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0177405     Document Type: Article

References (26)

1. Borchers S, Luther S, Lips U, Hahn N, Kontsendorn J, Stadler M, et al. Tetramer monitoring to assess risk factors for recurrent cytomegalovirus reactivation and reconstitution of antiviral immunity post allogeneic hematopoietic stem cell transplantation. Transplant Infectious Disease. 2011; 13(3):222-36. https://doi.org/10.1111/j.1399-3062.2011.00626.x PMID: 21585633
2. van der Torren CR, van Hensbergen Y, Luther S, Aghai Z, Rychnavská ZS, Slot M, et al. Possible Role of Minor H Antigens in the Persistence of Donor Chimerism after Stem Cell Transplantation; Relevance for Sustained Leukemia Remission. PLoS ONE. 2015; 10(3):e0119595. https://doi.org/10.1371/journal. pone.0119595 PMID: 25774796
3. Hamann D, Baars PA, Rep MHG, Hooibrink B, Kerkhof-Garde SR, Klein MR, et al. Phenotypic and Functional Separation of Memory and Effector Human CD8(+) T Cells. The Journal of Experimental Medicine. 1997; 186(9):1407-18. PMID: 9348298
4. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999; 401(6754):708-12. https://doi.org/10. 1038/44385 PMID: 10537110
5. Sallusto F, Geginat J, Lanzavecchia A. Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance. Annual Review of Immunology. 2004; 22(1):745-63.
6. Bondanza A, Hambach L, Aghai Z, Nijmeijer B, Kaneko S, Mastaglio S, et al. IL-7 receptor expression identifies suicide gene-modified allospecific CD8 T cells capable of self-renewal and differentiation into antileukemia effectors. Blood. 2011; 117(24):6469. https://doi.org/10.1182/blood-2010-11-320366 PMID: 21531977
7. Gerritsen B, P A. The memory of a killer T cell: models of CD8(+) T cell differentiation. Immunol Cell Biol. 2016;(Mar; 94(3)):236-4. https://doi.org/10.1038/icb.2015.118 PMID: 26700072
8. Kaech SM, Cui W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol. 2012; 12(11):749-61. https://doi.org/10.1038/nri3307 PMID: 23080391
9. Champagne P, Ogg GS, King AS, Knabenhans C, Ellefsen K, Nobile M, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 2001; 410(6824):106-11. https://doi.org/10.1038/ 35065118 PMID: 11242051
10. Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GMA, Papagno L, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002; 8(4):379-85. https://doi.org/10.1038/nm0402-379 PMID: 11927944
11. Breckpot K, Heirman C, De Greef C, van der Bruggen P, Thielemans K. Identification of New Antigenic Peptide Presented by HLA-Cw7 and Encoded by Several MAGE Genes Using Dendritic Cells Transduced with Lentiviruses. The Journal of Immunology. 2004; 172(4):2232-7. PMID: 14764691
12. Voehringer D, Blaser C, Brawand P, Raulet DH, Hanke T, Pircher H. Viral Infections Induce Abundant Numbers of Senescent CD8 T Cells. The Journal of Immunology. 2001; 167(9):4838-43. PMID: 11673487
13. Geginat J, Lanzavecchia A, Sallusto F. Proliferation and differentiation potential of human CD8 memory T-cell subsets in response to antigen or homeostatic cytokines. Blood. 2003; 101(11):4260. https://doi. org/10.1182/blood-2002-11-3577 PMID: 12576317
14. Rufer N, Zippelius A, Batard P, Pittet MJ, Kurth I, Corthesy P, et al. Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions. Blood. 2003; 102 (5):1779-87. https://doi.org/10.1182/blood-2003-02-0420 PMID: 12750165
15. Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 2003; 101 (7):2711-20. https://doi.org/10.1182/blood-2002-07-2103 PMID: 12433688
16. Chattopadhyay PK, Betts MR, Price DA, Gostick E, Horton H, Roederer M, et al. The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. Journal of Leukocyte Biology. 2009; 85(1):88-97. https://doi. org/10.1189/jlb.0208107 PMID: 18820174
17. Mahnke YD, Brodie TM, Sallusto F, Roederer M, Lugli E. The who's who of T-cell differentiation: Human memory T-cell subsets. European Journal of Immunology. 2013; 43(11):2797-809. https://doi. org/10.1002/eji.201343751 PMID: 24258910
18. Lugli E, Gattinoni L, Roberto A, Mavilio D, Price DA, Restifo NP, et al. Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells. Nat Protocols. 2013; 8(1):33-42. https://doi.org/10.1038/nprot.2012.143 PMID: 23222456
19. Mattis AE, Bernhardt G, Lipp M, Förster R. Analyzing cytotoxic T lymphocyte activity: a simple and reliable flow cytometry-based assay. Journal of Immunological Methods. 1997; 204(2):135-42. PMID: 9212830
20. O'Callaghan NJ, Fenech M. A quantitative PCR method for measuring absolute telomere length. Biological Procedures Online. 2011; 13:3-. https://doi.org/10.1186/1480-9222-13-3 PMID: 21369534
21. Wang F, Pan X, Kalmbach K, Seth-Smith ML, Ye X, Antumes DMF, et al. Robust measurement of telomere length in single cells. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(21):E1906-E12. https://doi.org/10.1073/pnas.1306639110 PMID: 23661059
22. Macchia I, Urbani F, Proietti E. Immune Monitoring in Cancer Vaccine Clinical Trials: Critical Issues of Functional Flow Cytometry-Based Assays. BioMed Research International. 2013; 2013:11.
23. Calarota SA, Baldanti F. Enumeration and Characterization of Human Memory T Cells by Enzyme-Linked Immunospot Assays. Clinical and Developmental Immunology. 2013; 2013:8.
24. Romero P, Zippelius A, Kurth I, Pittet MJ, Touvrey C, Iancu EM, et al. Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes. The Journal of Immunology. 2007; 178 (7):4112-9. PMID: 17371966
25. Hombrink P, Hadrup SR, Bakker A, Kester MGD, Falkenburg JHF, von dem Borne PA, et al. High-Throughput Identification of Potential Minor Histocompatibility Antigens by MHC Tetramer-Based Screening: Feasibility and Limitations. PLoS ONE. 2011; 6(8):e22523. https://doi.org/10.1371/journal. pone.0022523 PMID: 21850230
26. Scheinberg P, Melenhorst JJ, Brenchley JM, Hill BJ, Hensel NF, Chattopadhyay PK, et al. The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor. Blood. 2009; 114(24):5071. https://doi.org/10. 1182/blood-2009-04-214684 PMID: 19776383