Hematologic, hepatic, and renal function changes in hospitalized patients with Middle East respiratory syndrome coronavirus

International Journal of Laboratory Hematology

Volumn 39, Issue 3, 2017, Pages 272-278

  Al Tawfiq, J A ^a,b   Hinedi, K ^a   Abbasi, S ^a   Babiker, M ^a   Sunji, A ^a   Eltigani, M ^a  

^a DHAHRAN HEALTH CENTER   (Saudi Arabia)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

biochemical characteristics; hematologic changes; Middle East respiratory syndrome

Indexed keywords

ARTICLE; CLINICAL ARTICLE; CLINICAL OBSERVATION; COHORT ANALYSIS; HEMATOLOGY; HOSPITAL PATIENT; HUMAN; KIDNEY FUNCTION; LEUKOCYTE COUNT; LEUKOCYTOSIS; LEUKOPENIA; LIVER FUNCTION; LYMPHOCYTOPENIA; LYMPHOCYTOSIS; MIDDLE EAST RESPIRATORY SYNDROME; NEUTROPENIA; NEUTROPHIL COUNT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; THROMBOCYTOPENIA; THROMBOCYTOSIS; BLOOD; CORONAVIRUS INFECTION; FEMALE; HOSPITALIZATION; KIDNEY; KIDNEY FUNCTION TEST; LIVER; MALE; METABOLISM; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PATHOLOGY; VIROLOGY;

CORONAVIRUS INFECTIONS; FEMALE; HOSPITALIZATION; HUMANS; KIDNEY; KIDNEY FUNCTION TESTS; LEUKOCYTE COUNT; LEUKOCYTOSIS; LIVER; MALE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; RETROSPECTIVE STUDIES; THROMBOCYTOPENIA;

EID: 85018295139     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/ijlh.12620     Document Type: Article

References (23)

1. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus ADME, Fouchier RAM. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012;367:1814–20.
2. World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV) - Saudi Arabia. Disease outbreak news, 6 July 2016. Available at: http://www.who.int/csr/don/06-july-2016-mers-saudiarabia/en/. Accessed October 10, 2016.
3. Al-Tawfiq JA, Memish ZA. Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution. Trends Microbiol 2014;22:573–9.
4. Al-Tawfiq JA, Hinedi K, Ghandour J, Khairalla H, Musleh S, Ujayli A, Memish ZA. Middle East Respiratory Syndrome-Coronavirus (MERS-CoV): a case–control study of hospitalized patients. Clin Infect Dis 2014;59:160–5.
5. Arabi YM, Arifi AA, Balkhy HH, Najm H, Aldawood AS, Ghabashi A, Hawa H, Alothman A, Khaldi A, Al Raiy B. Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection. Ann Intern Med 2014;160:389–97.
6. Shalhoub S, Farahat F, Al-Jiffri A, Simhairi R, Shamma O, Siddiqi N, Mushtaq A. IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study. J Antimicrob Chemother 2015;70:2129–32.
7. Saad M, Omrani AS, Baig K, Bahloul A, Elzein F, Matin MA, Selim MA, Al Mutairi M, Al Nakhli D, Al Aidaroos AY, Al Sherbeeni N, Al-Khashan HI, Memish ZA, Albarrak AM. Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia. Int J Infect Dis 2014;29:301–6.
8. Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DA, Alabdullatif ZN, Assad M, Almulhim A, Makhdoom H, Madani H, Alhakeem R, Al-Tawfiq JA, Cotten M, Watson SJ, Kellam P, Zumla AI, Memish ZA, KSA MERS-CoV Investigation Team. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med 2013;369:407–16.
9. Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S, Al-Barrak A, Flemban H, Al-Nassir WN, Balkhy HH, Al-Hakeem RF, Makhdoom HQ, Zumla AI, Memish ZA. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 2013;13:752–61.
10. Eckerle I, Müller MA, Kallies S, Gotthardt DN, Drosten C. In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J 2013;10:359.
11. Corman VM, Albarrak AM, Omrani AS, Albarrak MM, Farah ME, Almasri M, Muth D, Sieberg A, Meyer B, Assiri AM, Binger T, Steinhagen K, Lattwein E, Al-Tawfiq J, Müller MA, Drosten C, Memish ZA. Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection. Clin Infect Dis 2016;62:477–83.
12. Hijawi B, Abdallat M, Sayaydeh A, Alqasrawi S, Haddadin A, Jaarour N, Alsheikh S, Alsanouri T. Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation. East Mediterr Health J 2013;19(Suppl. 1):S12–8.
13. Guery B, Poissy J, el Mansouf L, Séjourné C, Ettahar N, Lemaire X, Vuotto F, Goffard A, Behillil S, Enouf V, Caro V, Mailles A, Che D, Manuguerra JC, Mathieu D, Fontanet A, van der Werf S, MERS-CoV study group. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission. Lancet 2013;381:2265–72.
14. Memish ZA, Zumla AI, Al-Hakeem RF, Al-Rabeeah AA, Stephens GM. Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med 2013;368:2487–94.
15. Al-Tawfiq JA, Memish ZA. Managing MERS-CoV in the healthcare setting. Hosp Pract (1995) 2015;43:158–63.
16. Wong RSM, Wu A, To KF, Lee N, Lam CWK, Wong CK, Chan PK, Ng MH, Yu LM, Hui DS, Tam JS, Cheng G, Sung JJ. Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis. BMJ 2003;326:1358–62.
17. Zucker-Franklin D. The effect of viral infections on platelets and megakaryocytes. Semin Hematol 1994;31:329–37.
18. Leung GM, Hedley AJ, Ho L-M, Chau P, Wong IOL, Thach TQ, Ghani AC, Donnelly CA, Fraser C, Riley S, Ferguson NM, Anderson RM, Tsang T, Leung PY, Wong V, Chan JC, Tsui E, Lo SV, Lam TH. The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients. Ann Intern Med 2004;141:662–73.
19. Hui DSC, Chan PKS. Severe acute respiratory syndrome and coronavirus. Infect Dis Clin North Am 2010;24:619–38.
20. Fan CK, Yieh KM, Peng MY, Lin JC, Wang NC, Chang FY. Clinical and laboratory features in the early stage of severe acute respiratory syndrome. J Microbiol Immunol Infect 2006;39:45–53.
21. Regueiro-Mira MV, Pita-Fernández S, Pértega-Díaz S, López-Calviño B, Seoane-Pillado T, Fernández-Albalat-Ruiz M. Prognostic factors in adult patients hospitalized for pneumonia caused by Legionella pneumophila. Rev Chil Infectol 2015;32:435–44.
22. Kawamata R, Yokoyama K, Sato M, Goto M, Nozaki Y, Takagi T, Kumagai H, Yamagata T. Utility of serum ferritin and lactate dehydrogenase as surrogate markers for steroid therapy for Mycoplasma pneumoniae pneumonia. J Infect Chemother 2015;21:783–9.
23. Lu A, Wang C, Zhang X, Wang L, Qian L. Lactate dehydrogenase as a biomarker for prediction of refractory Mycoplasma pneumoniae pneumonia in children. Respir Care 2015;60:1469–75.