Reversible methylation of m6 Am in the 5′ cap controls mRNA stability

Nature

Volumn 541, Issue 7637, 2017, Pages 371-375

  Mauer, Jan ^a   Luo, Xiaobing ^b   Blanjoie, Alexandre ^c   Jiao, Xinfu ^b   Grozhik, Anya V ^a   Patil, Deepak P ^a   Linder, Bastian ^a   Pickering, Brian F ^a   Vasseur, Jean Jacques ^c   Chen, Qiuying ^a   Gross, Steven S ^a   Elemento, Olivier ^a   Debart, Françoise ^c   Kiledjian, Megerditch ^b   Jaffrey, Samie R ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6 N METHYLADENOSINE; ALPHA KETOGLUTARATE DEPENDENT DIOXYGENASE FTO; GUANOSINE; MESSENGER RNA; MICRORNA; 7-METHYLGUANOSINE; ADENOSINE; CAPPED RNA; FTO PROTEIN, HUMAN; MRNA DECAPPING ENZYMES; N(6),O(2)-DIMETHYLADENOSINE; N(6)-METHYLADENOSINE; RIBONUCLEASE; TRANSCRIPTOME;

BIOCHEMISTRY; CELLS AND CELL COMPONENTS; CYTOGENETICS; ENZYME; ENZYME ACTIVITY; METHYLATION; PROTEIN; RNA;

5' UNTRANSLATED REGION; ARTICLE; CATALYTIC EFFICIENCY; CONTROLLED STUDY; DEMETHYLATION; EMBRYO (ANATOMY); GENE OVEREXPRESSION; GENE SILENCING; HALF LIFE TIME; HEK293T CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; RNA DEGRADATION; RNA METHYLATION; RNA SEQUENCE; RNA STABILITY; RNA TRANSCRIPTION; THIN LAYER CHROMATOGRAPHY; TRANSCRIPTION INITIATION SITE; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; ENZYME SPECIFICITY; GENETIC EPIGENESIS; GENETICS; HEK293 CELL LINE; METABOLISM; METHYLATION;

ADENOSINE; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO; ANIMALS; ENDORIBONUCLEASES; EPIGENESIS, GENETIC; GUANOSINE; HALF-LIFE; HEK293 CELLS; HUMANS; MALE; METHYLATION; MICE; MICRORNAS; RNA CAPS; RNA STABILITY; SUBSTRATE SPECIFICITY; TRANSCRIPTION INITIATION SITE; TRANSCRIPTOME;

EID: 85018194065     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21022     Document Type: Article

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