메뉴 건너뛰기




Volumn 9, Issue 2, 2014, Pages 263-293

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE PROTEINS; CROSS-LINKING REAGENTS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; IMMUNOPRECIPITATION; MUTAGENESIS; PROTEIN INTERACTION MAPPING; RNA; RNA-BINDING PROTEINS; ULTRAVIOLET RAYS;

EID: 84893256374     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2014.012     Document Type: Article
Times cited : (202)

References (59)
  • 1
    • 78650306521 scopus 로고    scopus 로고
    • Small RNA sorting: Matchmaking for Argonautes
    • Czech, B. & Hannon, G.J. Small RNA sorting: matchmaking for Argonautes. Nat. Rev. Genet. 12, 19-31 (2011)
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 19-31
    • Czech, B.1    Hannon, G.J.2
  • 3
    • 77953629046 scopus 로고    scopus 로고
    • Regulation of mRNA translation and stability by microRNAs
    • Fabian, M.R., Sonenberg, N. & Filipowicz, W. Regulation of mRNA translation and stability by microRNAs. Annu. Rev. Biochem. 79, 351-379 (2010).
    • (2010) Annu. Rev. Biochem. , vol.79 , pp. 351-379
    • Fabian, M.R.1    Sonenberg, N.2    Filipowicz, W.3
  • 4
    • 67749132423 scopus 로고    scopus 로고
    • Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    • Chi, S.W., Zang, J.B., Mele, A. & Darnell, R.B. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 460, 479-486 (2009).
    • (2009) Nature , vol.460 , pp. 479-486
    • Chi, S.W.1    Zang, J.B.2    Mele, A.3    Darnell, R.B.4
  • 5
    • 84872489372 scopus 로고    scopus 로고
    • A functional assay for microRNA target identifcation and validation
    • Gaken, J. et al. A functional assay for microRNA target identifcation and validation. Nucleic Acids Res. 40, e75 (2012).
    • (2012) Nucleic Acids Res. , vol.40
    • Gaken, J.1
  • 6
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel, D.P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 7
    • 49949116902 scopus 로고    scopus 로고
    • The impact of microRNAs on protein output
    • Baek, D. et al. The impact of microRNAs on protein output. Nature 455, 64-71 (2008).
    • (2008) Nature , vol.455 , pp. 64-71
    • Baek, D.1
  • 8
    • 84857955708 scopus 로고    scopus 로고
    • An alternative mode of microRNA target recognition
    • Chi, S.W., Hannon, G.J. & Darnell, R.B. An alternative mode of microRNA target recognition. Nat. Struct. Mol. Biol. 19, 321-327 (2012).
    • (2012) Nat. Struct. Mol. Biol. , vol.19 , pp. 321-327
    • Chi, S.W.1    Hannon, G.J.2    Darnell, R.B.3
  • 9
    • 27944508215 scopus 로고    scopus 로고
    • CLIP: A method for identifying protein-RNA interaction sites in living cells
    • Ule, J., Jensen, K., Mele, A. & Darnell, R.B. CLIP: a method for identifying protein-RNA interaction sites in living cells. Methods 37, 376-386 (2005).
    • (2005) Methods , vol.37 , pp. 376-386
    • Ule, J.1    Jensen, K.2    Mele, A.3    Darnell, R.B.4
  • 10
    • 79960230895 scopus 로고    scopus 로고
    • Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data
    • Zhang, C. & Darnell, R.B. Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nat. Biotechnol. 29, 607-614 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 607-614
    • Zhang, C.1    Darnell, R.B.2
  • 11
    • 67649854477 scopus 로고    scopus 로고
    • Identifcation of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs
    • Granneman, S., Kudla, G., Petfalski, E. & Tollervey, D. Identifcation of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs. Proc. Natl. Acad. Sci. USA 106, 9613-9618 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9613-9618
    • Granneman, S.1    Kudla, G.2    Petfalski, E.3    Tollervey, D.4
  • 12
    • 23044431574 scopus 로고    scopus 로고
    • Nova regulates brain-specifc splicing to shape the synapse
    • Ule, J. et al. Nova regulates brain-specifc splicing to shape the synapse. Nat. Genet. 37, 844-852 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 844-852
    • Ule, J.1
  • 13
    • 32344440041 scopus 로고    scopus 로고
    • RNA binding proteins and the regulation of neuronal synaptic plasticity
    • Ule, J. & Darnell, R.B. RNA binding proteins and the regulation of neuronal synaptic plasticity. Curr. Opin. Neurobiol. 16, 102-110 (2006).
    • (2006) Curr. Opin. Neurobiol. , vol.16 , pp. 102-110
    • Ule, J.1    Darnell, R.B.2
  • 14
    • 33749056769 scopus 로고    scopus 로고
    • An RNA map predicting Nova-dependent splicing regulation
    • Ule, J. et al. An RNA map predicting Nova-dependent splicing regulation. Nature 444, 580-586 (2006).
    • (2006) Nature , vol.444 , pp. 580-586
    • Ule, J.1
  • 15
    • 77953928753 scopus 로고    scopus 로고
    • HITS-CLIP: Panoramic views of protein-RNA regulation in living cells
    • Darnell, R.B. HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley Interdiscip Rev. RNA 1, 266-286 (2010).
    • (2010) Wiley Interdiscip Rev. RNA , vol.1 , pp. 266-286
    • Darnell, R.B.1
  • 16
    • 0036354777 scopus 로고    scopus 로고
    • A two-tracked approach to analyze RNA-protein cross-linking sites in native, nonlabeled small nuclear ribonucleoprotein particles
    • Urlaub, H., Hartmuth, K. & Luhrmann, R. A two-tracked approach to analyze RNA-protein cross-linking sites in native, nonlabeled small nuclear ribonucleoprotein particles. Methods 26, 170-181 (2002).
    • (2002) Methods , vol.26 , pp. 170-181
    • Urlaub, H.1    Hartmuth, K.2    Luhrmann, R.3
  • 17
    • 0242497663 scopus 로고    scopus 로고
    • CLIP identifes Nova-regulated RNA networks in the brain
    • Ule, J. et al. CLIP identifes Nova-regulated RNA networks in the brain. Science 302, 1212-1215 (2003).
    • (2003) Science , vol.302 , pp. 1212-1215
    • Ule, J.1
  • 18
    • 56549105330 scopus 로고    scopus 로고
    • HITS-CLIP yields genome-wide insights into brain alternative RNA processing
    • Licatalosi, D.D. et al. HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature 456, 464-469 (2008).
    • (2008) Nature , vol.456 , pp. 464-469
    • Licatalosi, D.D.1
  • 19
    • 72849106592 scopus 로고    scopus 로고
    • RNA processing and its regulation: Global insights into biological networks
    • Licatalosi, D.D. & Darnell, R.B. RNA processing and its regulation: global insights into biological networks. Nat. Rev. Genet. 11, 75-87 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 75-87
    • Licatalosi, D.D.1    Darnell, R.B.2
  • 20
    • 61849139645 scopus 로고    scopus 로고
    • Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts
    • Sanford, J.R. et al. Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts. Genome Res. 19, 381-394 (2009).
    • (2009) Genome Res. , vol.19 , pp. 381-394
    • Sanford, J.R.1
  • 21
    • 79953180492 scopus 로고    scopus 로고
    • Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
    • Tollervey, J.R. et al. Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat. Neurosci. 14, 452-458 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 452-458
    • Tollervey, J.R.1
  • 22
    • 79960779323 scopus 로고    scopus 로고
    • FMRP Stalls ribosomal translocation on mRNAs linked to synaptic function and autism
    • Darnell, J.C. et al. FMRP Stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 146, 247-261 (2011).
    • (2011) Cell , vol.146 , pp. 247-261
    • Darnell, J.C.1
  • 23
    • 84887211390 scopus 로고    scopus 로고
    • The neuronal splicing factor Nova co-localizes with target RNAs in the dendrite
    • Racca, C. et al. The neuronal splicing factor Nova co-localizes with target RNAs in the dendrite. Front Neural Circuits 4, 5 (2010).
    • (2010) Front Neural Circuits , vol.4 , pp. 5
    • Racca, C.1
  • 24
    • 77953932362 scopus 로고    scopus 로고
    • Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling
    • Yano, M., Hayakawa-Yano, Y., Mele, A. & Darnell, R.B. Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling. Neuron 66, 848-858 (2010).
    • (2010) Neuron , vol.66 , pp. 848-858
    • Yano, M.1    Hayakawa-Yano, Y.2    Mele, A.3    Darnell, R.B.4
  • 25
    • 72149117411 scopus 로고    scopus 로고
    • Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping
    • Xue, Y. et al. Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol. Cell 36, 996-1006 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 996-1006
    • Xue, Y.1
  • 26
    • 84864020005 scopus 로고    scopus 로고
    • Ptbp2 represses adult-specifc splicing to regulate the generation of neuronal precursors in the embryonic brain
    • Licatalosi, D.D. et al. Ptbp2 represses adult-specifc splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 26, 1626-1642 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 1626-1642
    • Licatalosi, D.D.1
  • 27
    • 79960918737 scopus 로고    scopus 로고
    • Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability
    • Mukherjee, N. et al. Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Mol. Cell 43, 327-339 (2011).
    • (2011) Mol. Cell , vol.43 , pp. 327-339
    • Mukherjee, N.1
  • 28
    • 79960929333 scopus 로고    scopus 로고
    • Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
    • Lebedeva, S. et al. Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol. Cell 43, 340-352 (2011).
    • (2011) Mol. Cell , vol.43 , pp. 340-352
    • Lebedeva, S.1
  • 29
    • 84866505114 scopus 로고    scopus 로고
    • Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability
    • Ince-Dunn, G. et al. Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron 75, 1067-1080 (2012).
    • (2012) Neuron , vol.75 , pp. 1067-1080
    • Ince-Dunn, G.1
  • 30
    • 78149393552 scopus 로고    scopus 로고
    • ICLIP predicts the dual splicing effects of TIA-RNA interactions
    • Wang, Z. et al. iCLIP predicts the dual splicing effects of TIA-RNA interactions. PLoS Biol. 8, 1-16 (2010).
    • (2010) PLoS Biol. , vol.8 , pp. 1-16
    • Wang, Z.1
  • 31
    • 79953185674 scopus 로고    scopus 로고
    • Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
    • Polymenidou, M. et al. Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat. Neurosci. 14, 459-468 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 459-468
    • Polymenidou, M.1
  • 32
    • 77954387023 scopus 로고    scopus 로고
    • ICLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
    • Konig, J. et al. iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution. Nat. Struct. Mol. Biol. 17, 909-915 (2010).
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 909-915
    • Konig, J.1
  • 33
    • 59649107040 scopus 로고    scopus 로고
    • An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
    • Yeo, G.W. et al. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat. Struct. Mol. Biol. 16, 130-137 (2009).
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 130-137
    • Yeo, G.W.1
  • 34
    • 84864912095 scopus 로고    scopus 로고
    • Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy
    • Charizanis, K. et al. Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy. Neuron 75, 437-450 (2012).
    • (2012) Neuron , vol.75 , pp. 437-450
    • Charizanis, K.1
  • 35
    • 79551647673 scopus 로고    scopus 로고
    • Genome-wide identifcation of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs
    • Leung, A.K. et al. Genome-wide identifcation of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat. Struct. Mol. Biol. 18, 237-244 (2011).
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 237-244
    • Leung, A.K.1
  • 36
    • 84870951115 scopus 로고    scopus 로고
    • Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting
    • Loeb, G.B. et al. Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Mol. Cell 48, 760-770 (2012).
    • (2012) Mol. Cell , vol.48 , pp. 760-770
    • Loeb, G.B.1
  • 37
    • 84860539158 scopus 로고    scopus 로고
    • EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency
    • Riley, K.J. et al. EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 31, 2207-2221 (2012).
    • (2012) EMBO J. , vol.31 , pp. 2207-2221
    • Riley, K.J.1
  • 38
    • 76349122201 scopus 로고    scopus 로고
    • Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
    • Zisoulis, D.G. et al. Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat. Struct. Mol. Biol. 17, 173-179 (2010).
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 173-179
    • Zisoulis, D.G.1
  • 39
    • 77950920903 scopus 로고    scopus 로고
    • Transcriptome-wide identifcation of RNA-binding protein and microRNA target sites by PAR-CLIP
    • Hafner, M. et al. Transcriptome-wide identifcation of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141, 129-141 (2010).
    • (2010) Cell , vol.141 , pp. 129-141
    • Hafner, M.1
  • 40
    • 7044272280 scopus 로고    scopus 로고
    • Evidence for reassociation of RNA-binding proteins after cell lysis: Implications for the interpretation of immunoprecipitation analyses
    • Mili, S. & Steitz, J.A. Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analyses. RNA 10, 1692-1694 (2004).
    • (2004) RNA , vol.10 , pp. 1692-1694
    • Mili, S.1    Steitz, J.A.2
  • 41
    • 79959813870 scopus 로고    scopus 로고
    • A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins
    • Kishore, S. et al. A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat. Methods 8, 559-564 (2011).
    • (2011) Nat. Methods , vol.8 , pp. 559-564
    • Kishore, S.1
  • 42
    • 33845335788 scopus 로고    scopus 로고
    • Antiproliferative effect of 4-thiouridylate on OCM-1 uveal melanoma cells
    • Kemeny-Beke, A. et al. Antiproliferative effect of 4-thiouridylate on OCM-1 uveal melanoma cells. Eur. J. Ophthalmol. 16, 680-685 (2006).
    • (2006) Eur. J. Ophthalmol. , vol.16 , pp. 680-685
    • Kemeny-Beke, A.1
  • 43
    • 84886044727 scopus 로고    scopus 로고
    • 4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response
    • Burger, K. et al. 4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response. RNA Biol. 10 (2013).
    • (2013) RNA Biol. , vol.10
    • Burger, K.1
  • 44
    • 67149115119 scopus 로고    scopus 로고
    • Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    • Khan, A.A. et al. Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat. Biotechnol. 27, 549-555 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 549-555
    • Khan, A.A.1
  • 45
    • 84860389888 scopus 로고    scopus 로고
    • RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries
    • Hafner, M. et al. RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries. RNA 17, 1697-1712 (2011).
    • (2011) RNA , vol.17 , pp. 1697-1712
    • Hafner, M.1
  • 48
    • 84893265474 scopus 로고    scopus 로고
    • Mapping of in vivo RNA binding sites by UV-crosslinking immunoprecipitation (CLIP)
    • (eds Green, M. & Sambrook, J.), Cold Spring Harbor Laboratory Press
    • Darnell, J.C., Mele, A. & Darnell, R.B. Mapping of in vivo RNA binding sites by UV-crosslinking immunoprecipitation (CLIP). In Molecular Cloning: A Laboratory Manual (eds Green, M. & Sambrook, J.) (Cold Spring Harbor Laboratory Press, 2012).
    • (2012) Molecular Cloning: A Laboratory Manual
    • Darnell, J.C.1    Mele, A.2    Darnell, R.B.3
  • 49
    • 78751482329 scopus 로고    scopus 로고
    • How to slice: Snapshots of Argonaute in action
    • Parker, J.S. How to slice: snapshots of Argonaute in action. Silence 1, 3 (2010).
    • (2010) Silence , vol.1 , pp. 3
    • Parker, J.S.1
  • 50
    • 0034704248 scopus 로고    scopus 로고
    • Genome-wide location and function of DNA binding proteins
    • Ren, B. et al. Genome-wide location and function of DNA binding proteins. Science 290, 2306-2309 (2000).
    • (2000) Science , vol.290 , pp. 2306-2309
    • Ren, B.1
  • 51
    • 77953622163 scopus 로고    scopus 로고
    • Cracking pre-40S ribosomal subunit structure by systematic analyses of RNA-protein cross-linking
    • Granneman, S., Petfalski, E., Swiatkowska, A. & Tollervey, D. Cracking pre-40S ribosomal subunit structure by systematic analyses of RNA-protein cross-linking. EMBO J. 29, 2026-2036 (2010).
    • (2010) EMBO J. , vol.29 , pp. 2026-2036
    • Granneman, S.1    Petfalski, E.2    Swiatkowska, A.3    Tollervey, D.4
  • 52
    • 70449686545 scopus 로고    scopus 로고
    • Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis
    • Bohnsack, M.T. et al. Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis. Mol. Cell 36, 583-592 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 583-592
    • Bohnsack, M.T.1
  • 53
    • 84865201988 scopus 로고    scopus 로고
    • Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins
    • Wang, E.T. et al. Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell 150, 710-724 (2012).
    • (2012) Cell , vol.150 , pp. 710-724
    • Wang, E.T.1
  • 54
    • 84869086143 scopus 로고    scopus 로고
    • LIN28A is a suppressor of ER-associated translation in embryonic stem cells
    • Cho, J. et al. LIN28A is a suppressor of ER-associated translation in embryonic stem cells. Cell 151, 765-777 (2012).
    • (2012) Cell , vol.151 , pp. 765-777
    • Cho, J.1
  • 55
    • 75549089967 scopus 로고    scopus 로고
    • The UCSC Genome Browser database: Update 2010
    • Rhead, B. et al. The UCSC Genome Browser database: update 2010. Nucleic Acids Res. 38, D613-9 (2010).
    • (2010) Nucleic Acids Res. , vol.38
    • Rhead, B.1
  • 56
    • 0028685490 scopus 로고
    • Fitting a mixture model by expectation maximization to discover motifs in biopolymers
    • Bailey, T.L. & Elkan, C. Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc. Int. Conf. Intell. Syst. Mol. Biol. 2, 28-36 (1994).
    • (1994) Proc. Int. Conf. Intell. Syst. Mol. Biol. , vol.2 , pp. 28-36
    • Bailey, T.L.1    Elkan, C.2
  • 57
    • 84860153513 scopus 로고    scopus 로고
    • Using and understanding RepeatMasker
    • Tempel, S. Using and understanding RepeatMasker. Methods Mol. Biol. 859, 29-51 (2012).
    • (2012) Methods Mol. Biol. , vol.859 , pp. 29-51
    • Tempel, S.1
  • 58
    • 84936744064 scopus 로고    scopus 로고
    • Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions
    • Sugimoto, Y. et al. Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions. Genome Biol. 13, R67 (2012).
    • (2012) Genome Biol. , vol.13
    • Sugimoto, Y.1
  • 59
    • 22244452677 scopus 로고    scopus 로고
    • Distribution and intensity of constraint in mammalian genomic sequence
    • Cooper, G.M. et al. Distribution and intensity of constraint in mammalian genomic sequence. Genome Res 15, 901-913 (2005).
    • (2005) Genome Res , vol.15 , pp. 901-913
    • Cooper, G.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.