Multiphase analysis by linkage, quantitative transmission disequilibrium, and measured genotype: Systolic blood pressure in complex Mexican American pedigrees

BMC Proceedings

Volumn 8, Issue , 2014, Pages

  Chen, Zhijian ^a   Tan, Kuan Rui ^b   Bull, Shelley B ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT;

CHROMOSOME 3; CONFERENCE PAPER; DRUG USE; GENE LOCUS; GENEALOGY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; HYPERTENSION; MEXICAN AMERICAN; SEQUENCE ANALYSIS; SMOKING; SYSTOLIC BLOOD PRESSURE; WHOLE GENOME SEQUENCING;

EID: 85018193187     PISSN: None     EISSN: 17536561     Source Type: Journal    
DOI: 10.1186/1753-6561-8-S1-S108     Document Type: Conference Paper

References (8)

1. Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, et al: Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011, 478: 103-109. 10.1038/nature10405.
2. Almasy L, Dyer TD, Peralta JM, Jun G, Fuchsberger C, Almeida MA, Kent JW, Fowler S, Duggirala R, Blangero J: Data for Genetic Analysis Workshop 18: human whole genome sequence, blood pressure, and simulated phenotypes in extended pedigrees. BMC Proc. 2014, 8 (Suppl 1): S2-
3. Konigorski S, Yilmaz YE, Bull SB: Bivariate genetic association analysis of systolic and diastolic blood pressure by copula models. BMC Proc. 2014, 8 (Suppl 1): S72-
4. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet. 1998, 62: 1198-1211. 10.1086/301844.
5. Abecasis GR, Cookson WO, Cardon LR: Pedigree tests of transmission disequilibrium. Eur J Hum Genet. 2000, 8: 545-551. 10.1038/sj.ejhg.5200494.
6. Kent JW, Dyer TD, Göring HHH, Blangero J: Type I error rates in association versus joint linkage/association tests in related individuals. Genet Epidemiol. 2007, 31: 173-177. 10.1002/gepi.20200.
7. Nalpathamkalam T, Derkach A, Paterson AD, Merico D: Genetic Analysis Workshop 18 single-nucleotide variant prioritization based on protein impact, sequence conservation, and gene annotation. BMC Proc. 2014, 8 (Suppl 1): S11-
8. Wu Y, Briollais L: Mixed-effects models for joint modeling of sequence data in longitudinal studies. BMC Proc. 2014, 8 (Suppl 1): S92-