Type I error rates in association versus joint linkage/association tests in related individuals

Genetic Epidemiology

Volumn 31, Issue 2, 2007, Pages 173-177

  Kent Jr , Jack W ^a   Dyer, Thomas D ^a   Göring, Harald H H ^a   Blangero, John ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANALYTICAL ERROR; ARTICLE; COMPUTER SIMULATION; FEMALE; GENE IDENTIFICATION; GENE LOCATION; GENE NUMBER; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MODEL; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOMICS; GENOTYPE; HUMAN; HUMAN RELATION; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PEDIGREE ANALYSIS; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; COMPUTER SIMULATION; FALSE POSITIVE REACTIONS; FEMALE; GENE DOSAGE; GENE FREQUENCY; GENETIC MARKERS; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE DISEQUILIBRIUM; LOD SCORE; MALE; MODELS, GENETIC; NUCLEAR FAMILY; PEDIGREE; QUANTITATIVE TRAIT, HERITABLE; RANDOM ALLOCATION;

EID: 33846418780     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20200     Document Type: Article

References (13)

1. Abecasis GR, Cookson WO, Cardon LR. 2000. Pedigree tests of transmission disequilibrium. Eur J Hum Genet 8:545-551.
2. Almasy L, Blangero J. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
3. Blangero J. 2004. Localization and identification of human quantitative trait loci: King Harvest has surely come. Curr Opin Genet Dev 14:233-240.
4. Blangero J, Göring HHH, Kent JW Jr, Williams JT, Peterson CP, Almasy L, Dyer TD. 2005. Quantitative trait nucleotide analysis using Bayesian model selection. Hum Biol 77:541-559.
5. Bobadilla JL, Macek M Jr, Fine JP, Farrell PM. 2002. Cystic fibrosis: a worldwide analysis of CFTR mutations-correlation with incidence data and application to screening. Hum Mutat 19:575-606.
6. Curran JE, Jowett JB, Elliott KS, Gao Y, Gluschenko K, Wang J, Abel Azim DM, Cai G, Mahaney MC, Comuzzie AG, Dyer TD, Walder KR, Zimmet P, MacCluer JW, Collier GR, Kissebah AH, Blangero J. 2005. Genetic variation in selenoprotein S influences inflammatory response. Nat Genet 37:1234-1241.
7. Fulker DW, Cherny SS, Sham PC, Hewitt JK. 1999. Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 64:259-267.
8. Göring HHH, Terwilliger JD. 2000. Linkage analysis in the presence of errors IV: Joint pseudomarker analysis and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. Am J Hum Genet 66:1310-1327.
9. Havill LM, Dyer TD, Richardson DK, Mahaney MC, Blangero J. 2005. Quantitative trait linkage disequilibrium (QTLD) test: a more powerful alternative to QTDT for use in the absence of population stratification. BMC Genet 6(Suppl 1):S91.
10. Hopper JL, Mathews JD. 1982. Extensions to multivariate normal models for pedigree analysis. Ann Hum Genet 46:373-383.
11. Mitchell BD, Kammerer CM, Blangero J, Mahaney MC, Rainwater DL, Dyke B, Hixson JE, Henkel RD, Sharp M, Comuzzie AG, VandeBerg JL, Stern MP, MacCluer JW. 1996. Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans: the San Antonio Family Heart Study. Circulation 94:2159-2170.
12. Pritchard JK. 2001. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet 69:124-137.
13. Souto JC, Blanco-Vaca F, Soria JM, Buil A, Almasy L, Ordonez-Llanos J, Martin-Campos JM, Lathrop M, Stone W, Blangero J, Foncuberta J. 2005. A genomewide exploration suggests a new candidate gene at chromosome Hq23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am J Hum Genet 76:925-933.