Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions

ACS Nano

Volumn 11, Issue 1, 2017, Pages 12-18

  Anchordoquy, Thomas J ^a   Barenholz, Yechezkel ^b   Boraschi, Diana ^c   Chorny, Michael ^d   Decuzzi, Paolo ^e   Dobrovolskaia, Marina A ^f   Farhangrazi, Z Shadi ^g,h   Farrell, Dorothy ⁱ   Gabizon, Alberto ^j   Ghandehari, Hamidreza ^c   Godin, Biana ^k   La Beck, Ninh M ^l   Ljubimova, Julia ^m   Moghimi, S Moein ⁿ   Pagliaro, Len ^o   Park, Ji Ho ^p   Peer, Dan ^q   Ruoslahti, Erkki ^r   Serkova, Natalie J ^a   Simberg, Dmitri ^s  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^e CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^f ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^g FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^h Denver Technology Center   (United States)

ⁱ University of Denver   (United States)

^j NATIONAL CANCER INSTITUTE   (United States)

^k UNIVERSITY OF UTAH   (United States)

^l HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^m TEXAS TECH UNIVERSITY   (United States)

ⁿ CEDARS SINAI MEDICAL CENTER   (United States)

^o DURHAM UNIVERSITY   (United Kingdom)

^p Siva Therapeutics Inc   (United States)

^q Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^r TEL AVIV UNIVERSITY   (Israel)

^s BURNHAM INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; NANOPARTICLES; ONCOLOGY; SYNTHESIS (CHEMICAL);

CLINICAL APPLICATION; CLINICAL TRIAL; ENGINEERED NANOPARTICLES; NANO-FOCUS; STATUS QUO; SYNTHESIS AND CHARACTERIZATIONS;

MEDICAL NANOTECHNOLOGY;

ANTINEOPLASTIC AGENT; CONTRAST MEDIUM; NANOPARTICLE;

ANIMAL; CHEMISTRY; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEM; HUMAN; MOLECULARLY TARGETED THERAPY; NANOMEDICINE; NEOPLASM; PROCEDURES;

ANIMALS; ANTINEOPLASTIC AGENTS; CONTRAST MEDIA; DRUG DELIVERY SYSTEMS; HUMANS; MOLECULAR TARGETED THERAPY; NANOMEDICINE; NANOPARTICLES; NEOPLASMS;

EID: 85018193113     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.6b08244     Document Type: Review

References (40)

1. Weissig, V.; Pettinger, T. K.; Murdock, N. Nanopharmaceuticals (Part 1): Products on the Market Int. J. Nanomed. 2014, 9, 4357-4373 10.2147/IJN.S46900
2. Gabizon, A. A.; Patil, Y.; La-Beck, N. M. New Insights and Evolving Role of Pegylated Liposomal Doxorubicin in Cancer Therapy Drug Resist. Updates 2016, 29, 90-106 10.1016/j.drup.2016.10.003
3. Moghimi, S. M.; Farhangrazi, Z. S. Nanomedicine and the Complement Paradigm Nanomedicine 2013, 9, 458-460 10.1016/j.nano.2013.02.011
4. Bae, Y. H.; Park, K. Targeted Drug Delivery to Tumors: Myths, Reality and Possibility J. Controlled Release 2011, 153, 198-205 10.1016/j.jconrel.2011.06.001
5. Lammers, T.; Kiessling, F.; Hennink, W. E.; Storm, G. Drug Targeting to Tumors: Principles, Pitfalls and (Pre-) Clinical Progress J. Controlled Release 2012, 161, 175-187 10.1016/j.jconrel.2011.09.063
6. Inturi, S.; Wang, G.; Chen, F.; Banda, N. K.; Holers, V. M.; Wu, L.; Moghimi, S. M.; Simberg, D. Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake ACS Nano 2015, 9, 10758-10768 10.1021/acsnano.5b05061
7. Szebeni, J. Complement Activation-Related Pseudoallergy: A New Class of Drug-Induced Acute Immune Toxicity Toxicology 2005, 216, 106-121 10.1016/j.tox.2005.07.023
8. Chanan-Khan, A.; Szebeni, J.; Savay, S.; Liebes, L.; Rafique, N. M.; Alving, C. R.; Muggia, F. M. Complement Activation Following First Exposure to Pegylated Liposomal Doxorubicin (Doxil): Possible Role in Hypersensitivity Reactions Ann. Oncol. 2003, 14, 1430-1437 10.1093/annonc/mdg374
9. Sabnani, M. K.; Rajan, R.; Rowland, B.; Mavinkurve, V.; Wood, L. M.; Gabizon, A. A.; La-Beck, N. M. Liposome Promotion of Tumor Growth is Associated with Angiogenesis and Inhibition of Antitumor Immune Responses Nanomedicine 2015, 11, 259-262 10.1016/j.nano.2014.08.010
10. Moghimi, S. M. Cancer Nanomedicine and the Complement System Activation Paradigm: Anaphylaxis and Tumour Growth J. Controlled Release 2014, 190, 556-562 10.1016/j.jconrel.2014.03.051
11. Petersen, G. H.; Alzghari, S. K.; Chee, W.; Sankari, S. S.; La-Beck, N. M. Meta-Analysis of Clinical and Preclinical Studies Comparing the Anticancer Efficacy of Liposomal versus Conventional Non-Liposomal Doxorubicin J. Controlled Release 2016, 232, 255-264 10.1016/j.jconrel.2016.04.028
12. Choi, C. H.; Alabi, C. A.; Webster, P.; Davis, M. E. Mechanism of Active Targeting in Solid Tumors with Transferrin-Containing Gold Nanoparticles Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 1235-1240 10.1073/pnas.0914140107
13. Matsumura, Y.; Maeda, H. A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs Cancer Res. 1986, 46, 6387-6392
14. Zanganeh, S.; Hutter, G.; Spitler, R.; Lenkov, O.; Mahmoudi, M.; Shaw, A.; Pajarinen, J. S.; Nejadnik, H.; Goodman, S.; Moseley, M.; Coussens, L. M.; Daldrup-Link, H. E. Iron Oxide Nanoparticles Inhibit Tumour Growth by Inducing Pro-Inflammatory Macrophage Polarization in Tumour Tissues Nat. Nanotechnol. 2016, 11, 986-994 10.1038/nnano.2016.168
15. Sugahara, K. N.; Teesalu, T.; Karmali, P. P.; Kotamraju, V. R.; Agemy, L.; Girard, O. M.; Hanahan, D.; Mattrey, R. F.; Ruoslahti, E. Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors Cancer Cell 2009, 16, 510-520 10.1016/j.ccr.2009.10.013
16. Frazier, N.; Payne, A.; de Bever, J.; Dillon, C.; Panda, A.; Subrahmanyam, N.; Ghandehari, H. High Intensity Focused Ultrasound Hyperthermia for Enhanced Macromolecular Delivery J. Controlled Release 2016, 241, 186-193 10.1016/j.jconrel.2016.09.030
17. Lee, J.; Kim, J.; Jeong, M.; Lee, H.; Goh, U.; Kim, H.; Kim, B.; Park, J.-H. Liposome-Based Engineering of Cells To Package Hydrophobic Compounds in Membrane Vesicles for Tumor Penetration Nano Lett. 2015, 15, 2938-2944 10.1021/nl5047494
18. Kaneti, L.; Bronshtein, T.; Malkah Dayan, N.; Kovregina, I.; Letko Khait, N.; Lupu-Haber, Y.; Fliman, M.; Schoen, B. W.; Kaneti, G.; Machluf, M. Nanoghosts as a Novel Natural Nonviral Gene Delivery Platform Safely Targeting Multiple Cancers Nano Lett. 2016, 16, 1574-1582 10.1021/acs.nanolett.5b04237
19. Tanei, T.; Leonard, F.; Liu, X.; Alexander, J. F.; Saito, Y.; Ferrari, M.; Godin, B.; Yokoi, K. Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases Cancer Res. 2016, 76, 429-439 10.1158/0008-5472.CAN-15-1576
20. Shmeeda, H.; Amitay, Y.; Gorin, J.; Tzemach, D.; Mak, L.; Stern, S. T.; Barenholz, Y.; Gabizon, A. Coencapsulation of Alendronate and Doxorubicin in Pegylated Liposomes: A Novel Formulation for Chemoimmunotherapy of Cancer J. Drug Target. 2016, 24, 878-889 10.1080/1061186X.2016.1191081
21. Miller, M. A.; Gadde, S.; Pfirschke, C.; Engblom, C.; Sprachman, M. M.; Kohler, R. H.; Yang, K. S.; Laughney, A. M.; Wojtkiewicz, G.; Kamaly, N.; Bhonagiri, S.; Pittet, M. J.; Farokhzad, O. C.; Weissleder, R. Predicting Therapeutic Nanomedicine Efficacy Using a Companion Magnetic Resonance Imaging Nanoparticle Sci. Transl. Med. 2015, 7, 314ra183 10.1126/scitranslmed.aac6522
22. Moghimi, S. M.; Farhangrazi, Z. S. Just so Stories: The Random Acts of Anti-Cancer Nanomedicine Performance Nanomedicine 2014, 10, 1661-1666 10.1016/j.nano.2014.04.011
23. Lund, A. W.; Wagner, M.; Fankhauser, M.; Steinskog, E. S.; Broggi, M. A.; Spranger, S.; Gajewski, T. F.; Alitalo, K.; Eikesdal, H. P.; Wiig, H.; Swartz, M. A. Lymphatic Vessels Regulate Immune Microenvironments in Human and Murine Melanoma J. Clin. Invest. 2016, 126, 3389-3402 10.1172/JCI79434
24. Ghajar, C. M.; Peinado, H.; Mori, H.; Matei, I. R.; Evason, K. J.; Brazier, H.; Almeida, D.; Koller, A.; Hajjar, K. A.; Stainier, D. Y. R.; Chen, E. I.; Lyden, D.; Bissell, M. J. The Perivascular Niche Regulates Breast Tumour Dormancy Nat. Cell Biol. 2013, 15, 807-817 10.1038/ncb2767
25. Hazan-Halevy, I.; Landesman-Milo, D.; Rosenblum, D.; Mizrahy, S.; Ng, B. D.; Peer, D. Immunomodulation of Hematological Malignancies using Oligonucleotides Based-Nanomedicines J. Controlled Release 2016, 244, 149-156 10.1016/j.jconrel.2016.07.052
26. Wilhelm, S.; Tavares, A. J.; Dai, Q.; Ohta, S.; Audet, J.; Dvorak, H. F.; Chan, W. C. W. Analysis of Nanoparticle Delivery to Tumours Nat. Rev. Mater. 2016, 1, 16014 10.1038/natrevmats.2016.14
27. Decuzzi, P.; Pasqualini, R.; Arap, W.; Ferrari, M. Intravascular Delivery of Particulate Systems: Does Geometry Really Matter? Pharm. Res. 2009, 26, 235-243 10.1007/s11095-008-9697-x
28. Anselmo, A. C.; Mitragotri, S. Impact of Particle Elasticity on Particle-Based Drug Delivery Systems. Adv. Drug Delivery Rev. 2016, 10.1016/j.addr.2016.01.007.
29. Key, J.; Palange, A. L.; Gentile, F.; Aryal, S.; Stigliano, C.; Di Mascolo, D.; De Rosa, E.; Cho, M.; Lee, Y.; Singh, J.; Decuzzi, P. Soft Discoidal Polymeric Nanoconstructs Resist Macrophage Uptake and Enhance Vascular Targeting in Tumors ACS Nano 2015, 9, 11628-11641 10.1021/acsnano.5b04866
30. Seetharamu, N.; Kim, E.; Hochster, H.; Martin, F.; Muggia, F. Phase II Study of Liposomal Cisplatin (SPI-77) in Platinum-Sensitive Recurrences of Ovarian Cancer Anticancer Res. 2010, 30, 541-545
31. Silverman, L.; Barenholz, Y. In Vitro Experiments Showing Enhanced Release of Doxorubicin from Doxil(R) in the Presence of Ammonia May Explain Drug Release at Tumor Site Nanomedicine 2015, 11, 1841-1850 10.1016/j.nano.2015.06.007
32. Andriyanov, A. V.; Koren, E.; Barenholz, Y.; Goldberg, S. N. Therapeutic Efficacy of Combining Pegylated Liposomal Doxorubicin and Radiofrequency (RF) Ablation: Comparison between Slow-Drug-Releasing, Non-Thermosensitive and Fast-Drug-Releasing, Thermosensitive Nano-Liposomes PLoS One 2014, 9, e92555 10.1371/journal.pone.0092555
33. Alferiev, I. S.; Iyer, R.; Croucher, J. L.; Adamo, R. F.; Zhang, K.; Mangino, J. L.; Kolla, V.; Fishbein, I.; Brodeur, G. M.; Levy, R. J.; Chorny, M. Nanoparticle-Mediated Delivery of a Rapidly Activatable Prodrug of SN-38 for Neuroblastoma Therapy Biomaterials 2015, 51, 22-29 10.1016/j.biomaterials.2015.01.075
34. Tian, X.; Warner, S. B.; Wagner, K. T.; Caster, J. M.; Zhang, T.; Ohana, P.; Gabizon, A. A.; Wang, A. Z. Preclinical Evaluation of Promitil, a Radiation-Responsive Liposomal Formulation of Mitomycin C Prodrug, in Chemoradiotherapy Int. J. Radiat. Oncol., Biol., Phys. 2016, 96, 547-555 10.1016/j.ijrobp.2016.06.2457
35. Leonard, F.; Curtis, L. T.; Yesantharao, P.; Tanei, T.; Alexander, J. F.; Wu, M.; Lowengrub, J.; Liu, X.; Ferrari, M.; Yokoi, K.; Frieboes, H. B.; Godin, B. Enhanced Performance of Macrophage-Encapsulated Nanoparticle Albumin-Bound-Paclitaxel in Hypo-Perfused Cancer Lesions Nanoscale 2016, 8, 12544-12552 10.1039/C5NR07796F
36. Dobrovolskaia, M. A.; McNeil, S. E. Endotoxin and Engineered Nanomaterials. In Handbook of Immunological Properties of Engineered Nanomaperials; Dobrovolskaia, M. A.; McNeil, S. E., Eds.; World Scientific Publishing Ltd.: Singapore, 2013; pp 77-115.
37. Crist, R. M.; Grossman, J. H.; Patri, A. K.; Stern, S. T.; Dobrovolskaia, M. A.; Adiseshaiah, P. P.; Clogston, J. D.; McNeil, S. E. Common Pitfalls in Nanotechnology: Lessons Learned from NCI's Nanotechnology Characterization Laboratory Integr. Biol. 2013, 5, 66-73 10.1039/C2IB20117H
38. Vessillier, S.; Eastwood, D.; Fox, B.; Sathish, J.; Sethu, S.; Dougall, T.; Thorpe, S. J.; Thorpe, R.; Stebbings, R. Cytokine Release Assays for the Prediction of Therapeutic mAb Safety in First-In Man Trials-Whole Blood Cytokine Release Assays are Poorly Predictive for TGN1412 Cytokine Storm J. Immunol. Methods 2015, 424, 43-52 10.1016/j.jim.2015.04.020
39. Jones, S. W.; Roberts, R. A.; Robbins, G. R.; Perry, J. L.; Kai, M. P.; Chen, K.; Bo, T.; Napier, M. E.; Ting, J. P.; Desimone, J. M.; Bear, J. E. Nanoparticle Clearance is Governed by Th1/Th2 Immunity and Strain Background J. Clin. Invest. 2013, 123, 3061-3073 10.1172/JCI66895
40. Popp, M. K.; Oubou, I.; Shepherd, C.; Nager, Z.; ANderson, C.; Pagliaro, L. Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume J. Nanomater. 2014, 2014, 450670 10.1155/2014/450670