Modulatory Effects of a Nutraceutical Supplement on Saos-2 Cells Reveal Its Phlebotonic Activity

Journal of the American College of Nutrition

Volumn 36, Issue 4, 2017, Pages 268-272

  Ammendola, Sergio ^a   Loreto, Mario Di ^b   d'Abusco, Anna Scotto ^c  

^a AMBIOTEC sas   (Italy)

^b ASL Roma H   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

metalloproteases; nutraceuticals; osteoblasts; Phlebotonic; proinflammatory chemokine

Indexed keywords

CHEMOKINE; CYTOKINE; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN; NUTRACEUTICAL; TUMOR NECROSIS FACTOR; METALLOPROTEINASE;

ARTICLE; BLEEDING; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HEMORRHOID; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; OSTEOBLAST; PERIPHERAL VASCULAR DISEASE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SAOS-2 CELL LINE; CELL LINE; CELL SURVIVAL; DIETARY SUPPLEMENT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RESTLESS LEGS SYNDROME; VARICOSIS;

CELL LINE; CELL SURVIVAL; CYTOKINES; DIETARY SUPPLEMENTS; GENE EXPRESSION REGULATION; HUMANS; METALLOPROTEASES; OSTEOBLASTS; RESTLESS LEGS SYNDROME; VARICOSE VEINS;

EID: 85018181309     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2016.1269622     Document Type: Article

References (36)

1. Bilen O, Teruya J, :Complications of anticoagulation. Dis Mon 58:440–447, 2012.
2. Busti C, Falcinelli E, Momi S, Gresele P, :Matrix metalloproteases and peripheral arterial disease. Intern Emerg Med 5:13–25, 2010.
3. Ma Y, Yabluchanskiy A, Hall ME, Lindsey ML, :Using plasma matrix metalloprotease-9 and monocyte chemoattractant protein-1 to predict future cardiovascular events in subjects with carotid atherosclerosis. Atherosclerosis 232:231–233, 2014.
4. Yoshida S, Ono M, Shono T, Izumi H, Ishibashi T, Suzuki H, Kuwano M, :Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha–dependent angiogenesis. Mol Cell Biol 17:4015–4023, 1997.
5. Chen Q, Jin M, Yang F, Zhu J, Xiao Q, Zhang L, :Matrix metalloproteases:inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm 2013:928315, 2013.
6. Chae IG, Yu MH, Im N-H, Jung YT, Lee J, Chun KS, Lee I-S, :Effect of Rosemarinus officinalis L. on MMP-9, MCP-1 levels, and cell migration in RAW 264.7 and smooth muscle cells. J Med Food 15:879–886, 2012.
7. Pautke C, Schieker M, Tischer T, Kolk A, Neth P, Mutschler W, Milz S, :Characterization of osteosarcoma cell lines Mg-63, Saos-2 and U-2 Os in comparison to human osteoblasts. Anticancer Res 24:3743–3748, 2004.
8. Haidari F, Heybar H, Jalali MT, Helli B, Shirbeigi E, :Hesperidin supplementation modulates inflammatory responses following myocardial infarction. J Am Coll Nutr 34:205–211, 2015.
9. Pokrovsky AV, Saveljev BS, Kirienko AI, Bogachev VY, Zolotukhin IA, Sapelkin SV, :Stripping of the great saphenous vein under micronized purified flavonoid fraction (MPFF) protection (results of the Russian multicenter controller trial DEFANCE). Phlebolymphology 15:45–51, 2008.
10. Raffetto JD, Khalil RA, :Ca(2+)-dependent contraction by the saponoside escin in rat vena cava:implications in venotonic treatment of varicose veins. J Vasc Surg 54:489–496, 2011.
11. Vanscheidt W, Jost V, Wolna P, Lücker PW, Müller A, Theurer C, Patz B, Grützner KI, :Efficacy and safety of a Butcher's broom preparation (Ruscusaculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency. Arzneimittelforschung 52:243–250, 2002.
12. Jurenka JS, :Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa:a review of preclinical and clinical research. Altern Med Rev 14:141–153, 2009.
13. Tsuneki H, Sekizaki N, Suzuki T, Kobayashi S, Wada T, Okamoto T, Kimura I, Sasaoka T, :Coenzyme Q10 prevents high glucose–induced oxidative stress in human umbilical vein endothelial cells. Eur J Pharmacol 566:1–10, 2007.
14. Hayden MS, Ghosh S, :Signaling to NF-kappaB. Genes Dev 18:2195–2224, 2004.
15. Scotto d'Abusco A, Cicione C, Calamia V, Negri R, Giordano C, Grigolo B, Politi L, Scandurra R, :Glucosamine and its N-acetyl-phenylalanine derivative prevent TNF-alpha-induced transcriptional activation in human chondrocytes. Clin Exp Rheumatol 25:847–852, 2007.
16. Scotto d'Abusco A, Calamia V, Cicione C, Grigolo B, Politi L, Scandurra R, :Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes. Arthritis Res Ther 9:R104, 2007.
17. Goldring MB, Otero M, Plumb DA, Dragomir C, Favero M, El Hachem K, Hashimoto K, Roach HI, Olivotto E, Borzì RM, Marcu KB, :Roles of inflammatory and anabolic cytokines in cartilage metabolism:signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater 21:202–220, 2011.
18. Schmittegen TD, Livak KJ, :Analyzing real time PCR data by the comparative C(T) method. Nat Protoc 3:1101–1108, 2008.
19. Gigi R, Salai M, Dolkart O, Chechik O, Katzburg S, Stern N, Somjen D, :The effects of direct factor Xa inhibitor (Rivaroxaban) on the human osteoblastic cell line SaOS2. Connect Tissue Res 53:446–450, 2012.
20. Saito S, Trovato MJ, You R, Lal BK, Fasehun F, Padberg FP, Hobson RW, II, Durán WN, Pappas PJ, :Role of matrix metalloproteases 1, 2, and 9 and tissue inhibitor of matrix metalloprotease-1 in chronic venous insufficiency. J Vasc Surg 34:930–938, 2001.
21. Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T, :Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. Eur J Pharmacol 649:320–327, 2010.
22. Ramelet AA, :Management of chronic venous disease:the example of Daflon 500 mg. Phlebolymphology 16:321–330, 2009.
23. Spolarich AE, Andrews L, :An examination of the bleeding complications associated with herbal supplements, antiplatelet and anticoagulant medications. J Dent Hyg 81:67, 2007.
24. Ammendola S, Stoppoloni D, Di Loreto M, Scotto d'Abusco A, :A nutraceutical composition decreases CPK levels in Saos-2 cells and in patients with elevated serum levels of this enzyme. J Am Coll Nutr 35:559–567, 2016.
25. Lee Y-A, Ji H-I, Lee S-H, Hong S-J, Yang H-I, Yoo MC, Kim KS, :The role of adiponectin in the production of IL-6, IL-8, VEGF and MMPs in human endothelial cells and osteoblasts:implications for arthritic joints. Exp Mol Med 46:e72, 2014.
26. Bini A, Itoh Y, Kudryk BJ, Nagase H, :Degradation of cross-linked fibrin by matrix metalloprotease 3 (stromelysin 1):hydrolysis of the ç gly 404-Ala 405 peptide bond. Biochemistry 35:13056–13063, 1996.
27. Egashira K, :Molecular mechanisms mediating inflammation in vascular disease:special reference to monocyte chemoattractant protein-1. Hypertension 41:834–841, 2003.
28. Kitamoto S, Egashira K, Takeshita A, :Stress and vascular responses:anti-inflammatory therapeutic strategy against atherosclerosis and restenosis after coronary intervention. J Pharmacol Sci 91:192–196, 2003.
29. Zhu X-J, Wolff D, Zhang K-K, He W-W, Sun X-H, Lu Y, Zhou P, :Molecular inflammation in the contralateral eye after cataract surgery in the first eye. Invest Ophthalmol Vis Sci 56:5566–5573, 2015.
30. Pichert A, Schlorke D, Franz S, Arnhold J, :Functional aspects of the interaction between interleukin-8 and sulfated glycosaminoglycans. Biomatter 2:142–148, 2012.
31. Paiva KBS, Granjeiro JM, :Bone tissue remodeling and development:focus on matrix metalloprotease functions. Arch Biochem Biophys 561:74–87, 2014.
32. Jenkins G, :The role of proteases in transforming growth factor-b activation. Int J Biochem Cell Biol 40:1068–1078, 2008.
33. Thiolloy S, Edwards JR, Fingleton B, Rifkin DB, Matrisian L, Lynch CC, :An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS ONE 7:e29862, 2012.
34. Marneros AG, Olsen BR, :The role of collagen-derived proteolytic fragments in Angiogenesis. Matrix Biol 20:337–345, 2001.
35. Sudhakar A, Nyberg P, Keshamouni VG, Mannam AP, Li J, Sugimoto H, Cosgrove D, Kalluri R, :Human alpha1 type IV collagen domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin. J Clin Invest 115:2801–2810, 2005.
36. Kim Y-H, Kwon HJ, Kim DS, :Matrix metalloprotease 9 (MMP-9)-dependent processing of βig-h3 protein regulates cell migration, invasion, and adhesion. J Biol Chem 287:38957–38969, 2012.